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Human BDNF Protein expressed in Escherichia coli (E. coli) - ABIN413062
Kobayashi, Saito, Sato, Furusawa, Hosokawa, Tsutsumi, Asada, Kamada, Ohshima, Hisanaga: Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5. in The Journal of biological chemistry 2014
Human BDNF Protein expressed in Wheat germ - ABIN1346621
Martin Bauknight, Chakrabarty, Hwang, Malone, Joshi, Bruce, Sander Connolly, Winfree, Cunningham, Martin, Haque: Convection enhanced drug delivery of BDNF through a microcannula in a rodent model to strengthen connectivity of a peripheral motor nerve bridge model to bypass spinal cord injury. in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2012
One of the modulators of TOR (zeige FRAP1 Proteine) is brain-derived neurotrophic factor (BDNF), which activates the TOR (zeige FRAP1 Proteine) signaling pathway to promote protein synthesis, synapse strengthening, and the creation of new neural networks.findings demonstrate that TOR (zeige FRAP1 Proteine) activation in old animals occurs in the early phase of consolidation, and follows a pattern identical to that of BDNF expression.
These results suggest an involvement of the BDNF/TrkB (zeige NTRK2 Proteine) system in the regulation of food intake and energy balance in zebrafish, as in mammals
BDNF-TrkB (zeige NTRK2 Proteine) influences the expression level of components of chemokine (zeige CCL1 Proteine) signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.
Light regulates the expression of the BDNF/TrkB2 (zeige NTRK2 Proteine) system in the adult zebrafish retina.
Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (zeige RACGAP1 Proteine) (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3 (zeige PARD3 Proteine)) protein.
the results demonstrate that bdnf mediates non-cell-autonomous maintenance of position and thereby the identity of differentiated neurons
The present results demonstrate that there is a parallel time-related decline in the expression of BDNF and TrkB (zeige NTRK2 Proteine) in zebrafish.
The cloning and analysis of three additional zebrafish (Danio rerio) BDNF gene exons and two associated promoters, is reported. Among them are two exons that generate a novel tripartite mature transcript
Loss of BDNF is a major cause of the developmental abnormalities seen with huntingtin (zeige HTT Proteine) knockdown in zebrafish.
Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system.
BDNF suppresses neuromuscular junction maturation through cAMP-PKA signaling pathway
Findings demonstrate the neurotrophin, BDNF-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein (zeige MAG Proteine) .
These results indicate that brief sensory stimulation, by initiating nuclear transcription and de novo protein synthesis of BDNF, can facilitate the refinement of response properties in the developing visual system.
PACAP stimulates the expression of BDNF transcript IV.
The upstream open reading frames of BDNF transcripts I and IV markedly decrease BDNF translation efficiency, giving the first indication for a functional role of untranslated BDNF exons.
In the Xenopus melanotrope, BDNF biosynthesis and processing occur along the secretory granule maturation axis, together with that of POMC (zeige POMC Proteine)-derived alphaMSH (zeige POMC Proteine), and that the light controls the biosynthesis and secretion of BDNF and of POMC (zeige POMC Proteine) end-products.
BDNF released from the neural lobe of the pituitary gland acts as a neurohormone stimulating the secretory activity of the melanotrope cells in the intermediate pituitary lobe.
BDNF influences synaptic connectivity in multiple ways, promoting not only the morphological maturation of axonal arbors but also their stabilization, but also their stabilization.
BDNF, in addition to its neural and hormonal roles, can be released as a neurohormone from the neural pituitary lobe of X. laevis
Study showed that complex relationships exist between BDNF/TrkB (zeige NTRK2 Proteine) gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence
In a monkey model, cortical BDNF and activity regulated cytoskeletal-associated protein ARC (zeige Arc Proteine) expressions are strongly correlated with spontaneous physical activity.
A SNP is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene.
In monkey the decline of the BDNF protein level started earlier in the sensory and motor neocortical areas than in the association neocortical areas.
BDNF, a neurotrophic peptide essential for learning and memory, is down-regulated by tau proatein.
that brain-specific (zeige CALY Proteine) deletion of Efr3a (zeige EFR3A Proteine) could promote adult hippocampal neurogenesis, presumably by upregulating the expression of BDNF and its receptor
Brain and liver Bdnf mRNA showed a 12-h phase shift when fed ketogenic diet (KD) compared with high-fat diet (HFD) or low-fat diet (LFD).
In vivo reduced levels of GSK3beta phosphorylation in the retinal tissues of the BDNF(+/-) animals implicating critical role of BDNF in the regulation of the GSK3beta activity.
we showed that gravity changes induced differential modulation of gene expression of BDNF and 5-HTRs (5-HT1AR, 5-HT1BR and 5-HT2AR) in some brain regions. The modulation of gene expression may constitute molecular bases that underlie behavioral alteration induced by gravity changes.
Different exons of BDNF have unique expression patterns following exercise and maternal separation in the female hippocampus.
study examined the effect of molar loss and powder diet on memory ability and the expression of BDNF mRNA in the hippocampus of adult mice; results suggest the effect of molar loss and powder diet on memory function and BDNF mRNA levels were different, molar loss may have a greater long-term effect on memory ability than powder diet does
This study demonstrated that BDNF is required for nerve regeneration following gustatory nerve section.
Activity-dependent and brain-derived neurotrophic factor-dependent neuroplasticity within the orbitofrontal cortex coordinate outcome-based decision making through interactions with the amygdala. These interactions break reward-seeking habits, a putative factor in multiple psychopathologies.
findings show that BDNF-TrkB (zeige NTRK2 Proteine) signaling, rather than Dopamine signaling, in the Ventral Tegmental Area -Nuc (zeige SREBF2 Proteine). Accumbens circuit is crucial for facilitating depressive-like depressive-like outcomes after Chronic Social Defeat Stress and they establish BDNF-TrkB (zeige NTRK2 Proteine) signaling as a pathologic mechanism during periods of chronic stress.
Vietnam veterans (n = 257) screened for posttraumatic stress disorde and controlled for trauma exposure were genotyped for BDNF Val66Met
Serum BDNF was positively associated with a composite z-score of cardiovascular risk factors
This study did not detect significant differences in cognitive or mood outcomes between patients who have the val66val or met versions of the BDNF polymorphism
Aadvanced glcyation end products induce BDNF release from human platelets through the activation of the Src (zeige SRC Proteine)-Syk (zeige SYK Proteine)-(possibly phospholipase C (zeige PLC Proteine))-Ca(2 (zeige CA2 Proteine)+) pathway as a biological defense in the early phase of diabetes.
Patients carrying both the BDNF Val66Val and COMT (zeige COMT Proteine) Met158Met variants had higher alcohol consumption.
In contrast to the more typical view regarding this BDNF polymorphism, the data are consistent with the perspective that in the presence of synaptic plasticity presumably associated with the Val/Val genotype, neglect allows for the emergence of specific appraisal and coping styles, which are tied to depression
Observed differences in serum BDNF levels, genetic variants, and DNA methylation (zeige HELLS Proteine) patterns across different glucose metabolic state suggest that BDNF may be involved in the pathophysiological process of insulin (zeige INS Proteine) resistance and type 2 diabetes.
overexpression of TrkB (zeige NTRK2 Proteine), but not of BDNF, is significantly associated with a poor survival outcome for TNBC patients.
Study demonstrated an association between higher DNA methylation (zeige HELLS Proteine) of the BDNF promoter and PTSD diagnosis in combat-exposed individuals.
The data of this study show a significant increase in DNA methylation (zeige HELLS Proteine) of BDNF in peripheral blood mononuclear cells of major depressive disorder patients.
These observations provided evidence that brain-derived naeurotrophic factor(BDNF) and its receptor (BDNF receptor) secreted by bovine sperm was important in regulation of insulin (zeige INS Proteine) and leptin (zeige LEP Proteine).
Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic pathway involving BDNF.
Lf upregulated several canonical signaling pathways associated with neurodevelopment and cognition and influenced ~10 genes involved in the brain-derived neurotrophin factor (BDNF) signaling pathway.
Taken together, these data indicate that recurrent tethering stress in sows over 4.5 years results in a loss of neurotrophic support by BDNF, mediated by an overactive neuroendocrine system.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (zeige MMP9 Proteine) and MMP-2 (zeige MMP2 Proteine), caspase-3 (zeige CASP3 Proteine) and BDNF
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene.
brain-derived neurotrophic factor
, brain derived neurotrophic factor
, anorexia BDNF
, brain derived neurothrophic factor
, neurotrophic factor