anti-Ratte (Rattus) AXL Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended AXL Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
AXL Receptor tyrosine Kinase (AXL) Antikörper
  • JTK11
  • UFO
  • AI323647
  • Ark
  • Tyro7
  • Ufo
  • AXL receptor tyrosine kinase
  • Axl receptor tyrosine kinase
  • AXL
  • Axl
Epitop
AA 180-230
28
24
22
19
18
18
16
16
15
14
11
9
8
6
6
6
6
6
5
5
5
4
4
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
265
114
62
5
2
2
1
1
1
1
Wirt
Kaninchen
173
98
43
6
1
Klonalität
Polyklonal
Konjugat
Dieser AXL Antikörper ist unkonjugiert
17
13
11
10
10
10
9
8
8
8
8
8
6
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
187
113
107
55
29
25
14
10
8
7
5
3
2
2
2
2
1
1
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN756022
$ 295.90
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN756037 IF (p) IHC (p) WB Rabbit IgG pTyr698, pTyr702, pTyr703 Anmelden zum Anzeigen Polyclonal
1 ABIN756031 IHC (p) WB HRP Rabbit IgG AA 180-230 Anmelden zum Anzeigen Polyclonal
1 ABIN756046 IHC (p) WB HRP Rabbit IgG pTyr698, pTyr702, pTyr703 Anmelden zum Anzeigen Polyclonal
1 ABIN756024 IHC (p) WB Biotin Rabbit IgG AA 180-230 Anmelden zum Anzeigen Polyclonal
1 ABIN1732158 IHC (p) WB Rabbit IgG AA 450-500 Anmelden zum Anzeigen Polyclonal
1 ABIN756039 IHC (p) WB Biotin Rabbit IgG pTyr698, pTyr702, pTyr703 Anmelden zum Anzeigen Polyclonal
1 ABIN2883509 ELISA IHC (p) WB Rabbit IgG pTyr691 Anmelden zum Anzeigen Polyclonal

General

Antigen AXL Receptor tyrosine Kinase (AXL) Antikörper
Epitop AA 180-230
(28), (24), (22), (19), (18), (18), (16), (16), (15), (14), (11), (9), (8), (6), (6), (6), (6), (6), (5), (5), (5), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(265), (114), (62), (5), (2), (2), (1), (1), (1), (1)
Wirt Kaninchen
(173), (98), (43), (6), (1)
Klonalität
Polyklonal
Konjugat Dieser AXL Antikörper ist unkonjugiert
(17), (13), (11), (10), (10), (10), (9), (8), (8), (8), (8), (8), (6), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(187), (113), (107), (55), (29), (25), (14), (10), (8), (7), (5), (3), (2), (2), (2), (2), (1), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-AXL Antikörper

Target Details AXL Anwendungsinformationen Handhabung Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human AXL
Isotyp IgG

Target Details AXL

Produktdetails anti-AXL Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung Axl (AXL Antibody Abstract)
Hintergrund

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3, but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor.

Subcellular location: Extracellular

Synonyms: UFO, JTK11, Tyrosine-protein kinase receptor UFO, AXL oncogene, AXL

Gen-ID 558
UniProt P30530
Pathways RTK Signalweg, Cellular Response to Molecule of Bacterial Origin

Anwendungsinformationen

Produktdetails anti-AXL Antikörper Target Details AXL Handhabung Bilder zurück nach oben
Applikationshinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-AXL Antikörper Target Details AXL Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Bilder

Produktdetails anti-AXL Antikörper Target Details AXL Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-AXL Receptor tyrosine Kinase (AXL) (AA 180-230) antibody (ABIN756022) Formalin-fixed and paraffin embedded human colon carcinoma labeled with Rabbit Anti A...
Immunohistochemistry (IHC) image for anti-AXL Receptor tyrosine Kinase (AXL) (AA 180-230) antibody (ABIN756022) Formalin-fixed and paraffin embedded mouse embryo labeled with Rabbit Anti AXL/UFO Po...