anti-Ratte (Rattus) AXL Antikörper für Enzyme Immunoassay

Recommended AXL Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
AXL Receptor tyrosine Kinase (AXL) Antikörper
  • JTK11
  • UFO
  • AI323647
  • Ark
  • Tyro7
  • Ufo
  • AXL receptor tyrosine kinase
  • Axl receptor tyrosine kinase
  • AXL
  • Axl
Epitop
AA 843-864
28
24
19
18
18
16
14
12
12
11
10
9
8
6
6
6
6
5
5
5
4
4
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
Reaktivität
Human, Affe, Maus, Ratte (Rattus)
248
105
63
5
2
2
1
1
1
1
Wirt
Kaninchen
173
83
33
4
1
Klonalität
Polyklonal
Konjugat
Dieser AXL Antikörper ist unkonjugiert
14
12
10
8
8
7
7
7
6
6
6
6
6
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Applikation
Enzyme Immunoassay (EIA), Western Blotting (WB)
184
107
86
54
30
26
14
10
7
5
2
2
2
1
1
1
1
1
1
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Produktnummer ABIN492797
462,00 €
Zzgl. Versandkosten 20,00 € und MWSt

anti-AXL Antikörper für Enzyme Immunoassay mit den meisten Publikationen

Ähnliche anti-AXL Antikörper

Applikation / Reaktivität Human Ratte (Rattus) Maus Affe
Immunofluorescence (fixed cells) (IF/ICC) 1 Antikörper 1 Antikörper
Cytometry by Time of Flight (CyTOF) 1 Antikörper
Simple Western (SimWes) 1 Antikörper
Western Blotting (WB) 161 Antikörper 53 Antikörper 33 Antikörper 6 Antikörper
RNA Interference (RNAi) 2 Antikörper
Immunoprecipitation (IP) 9 Antikörper 5 Antikörper 6 Antikörper 2 Antikörper
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 30 Antikörper 8 Antikörper 8 Antikörper 1 Antikörper
Immunohistochemistry (IHC) 52 Antikörper 8 Antikörper 10 Antikörper

General

Antigen AXL Receptor tyrosine Kinase (AXL) Antikörper
Epitop AA 843-864
(28), (24), (19), (18), (18), (16), (14), (12), (12), (11), (10), (9), (8), (6), (6), (6), (6), (5), (5), (5), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reaktivität Human, Affe, Maus, Ratte (Rattus)
(248), (105), (63), (5), (2), (2), (1), (1), (1), (1)
Wirt Kaninchen
(173), (83), (33), (4), (1)
Klonalität
Polyklonal
Konjugat Dieser AXL Antikörper ist unkonjugiert
(14), (12), (10), (8), (8), (7), (7), (7), (6), (6), (6), (6), (6), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Applikation Enzyme Immunoassay (EIA), Western Blotting (WB)
(184), (107), (86), (54), (30), (26), (14), (10), (7), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 2 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-AXL Antikörper

Target Details AXL Anwendungsinformationen Handhabung ProductDetails: References for anti-AXL antibody (ABIN492797) Bilder
Spezifität This antibody detects a single 130 kDa AXL protein. The antibody also reacts weakly to a 45 kDa protein in rat testis extracts.
Kreuzreaktivität (Details) Species reactivity (tested):Human, Monkey, Mouse, Rat
Reinigung Affinity chromatography
Immunogen Peptide selected from position 843-864

Target Details AXL

Produktdetails anti-AXL Antikörper Anwendungsinformationen Handhabung ProductDetails: References for anti-AXL antibody (ABIN492797) Bilder zurück nach oben
Antigen
Andere Bezeichnung AXL / UFO (AXL Antibody Abstract)
Hintergrund Axl, also known as UFO, Tyro 7 and ARK, is a receptor tyrosine kinase, is involved in cell survival, proliferation, and migration and have sequence homology with other 2 members of the receptor tyrosine kinase family, MER and Tyro3. This tyrosine kinase is activated by the Growth Arrest Gene 6 (GAS 6) that binds and activated the kinase domin of this receptor kinase. Based on sequence homology and secondary structure predictions, AXL putative protein has a tyrosine kinase domain with unique 2 immunoglobulin like domain in the C-terminal end. It also has 2 fibronectin type III domains which are found on proteins such as receptor tyrosine phosphatases, and cell adhesion molecules. The expression of mRNA for this gene was noted in broad spectrum of developing tissues (e.g. subepidermal cells of the skin, mesenchymal cells of the periosteum). AXL expression is also detected in most cell lines and adult tissues except those of the hmatopoietic lineage (1, 2). The receptor Axl is expressed in primary prostate carcinoma and in prostate cancer cell lines as such as PC-3 and DU 145. Axl expression increases in the neointima of balloon-injured rat carotids due to the oxidative stress which also plays a role in remodeling of injured vessels. Several cancer cell lines express Axl protein including primary prostate carcinoma and in prostate cancer cell lines as such as PC-3 and DU 145, myeloid leukemia. GAS 6 activation of Axl is also invloved in experimental nephritis model and spermatogenesis (3). IN testis, AXL is expressed in sertoli and leydig cell of the mature testis. The receptor tyrosine kinase AXL protein has has at least 2 variants (AXL1, AXL 2) and is a approximately 130 kDa (888 amino acids) protein. The AXL protein has simlar functional domins as its other family members and has a tyrosine kinase domain closer to the C-terminal region and putative phosphorylation sites.Synonyms: Tyrosine-protein kinase receptor UFO
Gen-ID 558
NCBI Accession NP_001690
UniProt P30530
Forschungsgebiet Kinases/Phosphatases
Pathways RTK Signalweg, Cellular Response to Molecule of Bacterial Origin

Anwendungsinformationen

Produktdetails anti-AXL Antikörper Target Details AXL Handhabung ProductDetails: References for anti-AXL antibody (ABIN492797) Bilder zurück nach oben
Applikationshinweise ELISA. Western blot 1: 500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-AXL Antikörper Target Details AXL Anwendungsinformationen ProductDetails: References for anti-AXL antibody (ABIN492797) Bilder zurück nach oben
Konzentration 0.65 - 1.25 mg/mL
Buffer Stabilization buffer
Handhabung Avoid repeated freezing and thawing.
Lagerung -20 °C
Informationen zur Lagerung Store (in aliquots) at -20 °C.

ProductDetails: References for anti-AXL antibody (ABIN492797)

Produktdetails anti-AXL Antikörper Target Details AXL Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Sainaghi, Castello, Bergamasco, Galletti, Bellosta, Avanzi: "Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor." in: Journal of cellular physiology, Vol. 204, Issue 1, pp. 36-44, 2005

Rescigno, Mansukhani, Basilico: "A putative receptor tyrosine kinase with unique structural topology." in: Oncogene, Vol. 6, Issue 10, pp. 1909-13, 1991