UPP1 Proteine (UPP1)

Bezeichnung:
Uridine Phosphorylase 1 Proteine (UPP1)
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Synonyme:
AI325217, im:6911242, UdRPase, Up, UPase, Upp, upp1, zgc:110755
alle Proteine anzeigen Gen GeneID UniProt
UPP1 7378 Q16831
UPP1 22271 P52624
Ratte UPP1 UPP1 289801  

Weitere Synonyme anzeigen

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Am meisten referenzierte UPP1 Proteine

  1. Human UPP1 Protein expressed in Escherichia coli (E. coli) - ABIN667819 : Kanzaki, Takebayashi, Bando, Eliason, Watanabe Si, Miyashita, Fukumoto, Toi, Uchida: Expression of uridine and thymidine phosphorylase genes in human breast carcinoma. in International journal of cancer. Journal international du cancer 2002 (PubMed)
    Zeige alle 2 Referenzen für 667819

Weitere Proteine zu UPP1 Interaktionspartnern

Human Uridine Phosphorylase 1 (UPP1) Interaktionspartner

  1. there are inter-ethnic differences for uridine phosphorylase 1 (UPP1) and zinc finger-SWIM containing 4 (ZSWIM4) in response to 1alpha,25(OH)2D3

  2. Data show that enhanced cytotoxicity of 5-FU by bFGF (zeige FGF2 Proteine) through modulating the expression of UPP1 at the transcription level.

  3. The expression level of UPase gene may be an independent prognostic marker in human breast carcinoma

  4. Characterization of the promoter region of UPase has indicated a direct regulation of its expression by the tumor suppressor gene p53 (zeige TP53 Proteine). Review.

  5. Thymidine phosphorylase (zeige TYMP Proteine) and uridine phosphorylase were both responsible for converting 5'dFUrd/5FU into 5FU/FUrd, respectively

  6. The presented structures confirm that hUPP1 (zeige PTP4A2 Proteine) is dimeric. They also reveal the mechanism by which 5-benzylacyclouridine engages the active site of the protein and disables the enzyme by locking the protein in a closed conformation.

Mouse (Murine) Uridine Phosphorylase 1 (UPP1) Interaktionspartner

  1. Importance of UPase in the activation of fluoropyrimidines, the effect of uridine in protecting normal tissues, and the role for tumor-specific modulation of the phosphorolytic activity in 5-FU or capecitabine-based chemotherapy.

  2. Data show that enhanced cytotoxicity of 5-FU by bFGF (zeige FGF2 Proteine) through modulating the expression of UPP1 at the transcription level.

  3. Targeted deletion of both thymidine phosphorylase (zeige TYMP Proteine) and uridine phosphorylase and consequent disorders in mice.

  4. UPase is a critical enzyme in the regulation of uridine homeostasis and pyrimidine nucleotide metabolism, and 5-fluorouracil activity

  5. Taken together, the present study provides the first evidence that uridine protects neurons against ischemic insult-induced neuronal death, possibly through the action of UPase.

  6. Thymidine phosphorylase (zeige TYMP Proteine) and UPP1 double knockout mice showed increased thymidine and deoxyuridine in tissues and developed encephalopathy.

UPP1 Protein Überblick

Protein Überblick

The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP\; EC 2.4.2.3) and thymidine phosphorylase (TP\; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995

Alternative names and synonyms associated with UPP1

  • uridine phosphorylase 1 (upp1)
  • uridine phosphorylase 1 (udp_1)
  • uridine phosphorylase 1 (Tsp_02326)
  • Uridine phosphorylase 1 (upp1)
  • uridine phosphorylase 1 (LOC100224766)
  • uridine phosphorylase 1 (UPP1)
  • uridine phosphorylase 1 (Upp1)
  • uridine phosphorylase 1-like (LOC100625277)
  • uridine phosphorylase 1-like (LOC100357952)
  • AI325217 Protein
  • im:6911242 Protein
  • UdRPase Protein
  • Up Protein
  • UPase Protein
  • Upp Protein
  • upp1 Protein
  • zgc:110755 Protein

Bezeichner auf Proteinebene für Uridine Phosphorylase 1 Proteine (UPP1)

uridine phosphorylase 1 , Uridine phosphorylase 1 , UPase 1 , urdPase 1

GENE ID SPEZIES
496532 Xenopus (Silurana) tropicalis
3703440 Natronomonas pharaonis DSM 2160
10907966 Trichinella spiralis
100196719 Salmo salar
100224766 Taeniopygia guttata
100528868 Ictalurus punctatus
7378 Homo sapiens
503707 Danio rerio
420942 Gallus gallus
515029 Bos taurus
22271 Mus musculus
289801 Rattus norvegicus
100727838 Cavia porcellus
100625277 Sus scrofa
100357952 Oryctolagus cuniculus
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