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Results show that MAT2B expression is frequently upregulated in malignant melanoma tissues. MAT2B downregulation delays tumor growth in vivo, and suppressed cell growth, colony formation ability and induced apoptosis in vitro indicating that MAT2B is critical for melanoma cell proliferation and tumorigenicity.
Interaction between MAT2B and GIT1 serves as a scaffold and facilitates signaling in multiple steps of the Ras/Raf (zeige RAF1 ELISA Kits)/MEK (zeige MAP2K1 ELISA Kits)/ERK (zeige EPHB2 ELISA Kits) pathway
resveratrol induces HuR (zeige ELAVL1 ELISA Kits), SIRT1 (zeige SIRT1 ELISA Kits), and MAT2B expression; the last may represent a compensatory response against apoptosis and growth inhibition.
MAT2B and GIT1 form a scaffold, which recruits and activates MEK (zeige MAP2K1 ELISA Kits) and ERK (zeige EPHB2 ELISA Kits) to promote growth and tumorigenesis.
The structure of MAT2B reveals a short-chain dehydrogenase/reductase (SDR (zeige SDPR ELISA Kits)) core with specificity for the NADP/H cofactor, and harbors the SDR (zeige SDPR ELISA Kits) catalytic triad.
Coexpression of MAT2A (zeige MAT2A ELISA Kits) and MAT2B in COS-1 cells resulted in significantly increased MAT enzyme activity.
Data show MAT2beta variants reside mostly in the nucleus and regulate HuR (zeige ELAVL1 ELISA Kits) subcellular content to affect cell proliferation.
Lower expression of both MAT2A (zeige MAT2A ELISA Kits) and MAT2beta and interfere with leptin (zeige LEP ELISA Kits) signaling in liver cancer cells.
Splicing variants of MAT2beta are up-regulated in hepatocellular carcinoma and regulated tumor cell growth and death.
a switch in MAT expression in liver cancer was accompanied by increasing expression of MAT2B
MAT2B acted as a positive regulator through modifying S- adenosylmethionine levels as well as activating AKT (zeige AKT1 ELISA Kits)/ERK (zeige MAPK1 ELISA Kits) signaling pathway to promote porcine intramuscular adipocyte differentiation.
These data demonstrated an obesity-related expression variation of the MAT II beta subunit (zeige POLG ELISA Kits) in skeletal muscle and adipose tissue in pigs.
The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms.
methionine adenosyltransferase II, beta
, methionine adenosyltransferase 2 subunit beta
, MAT II beta
, methionine adenosyltransferase 2 beta subunit
, methionine adenosyltransferase 2 subunit beta-like
, beta regulatory subunit of methionine adenosyltransferase
, dTDP-4-keto-6-deoxy-D-glucose 4-reductase
, putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase
, putative protein product of Nbla02999
, short chain dehydrogenase/reductase family 23E, member 1
, methionine adenosyltransferase 2beta
, methionine adenosyltransferase II beta