anti-Glycyl-tRNA Synthetase (GARS) Antikörper

Bezeichnung:
anti-Glycyl-tRNA Synthetase Antikörper (GARS)
Auf www.antikoerper-online.de finden Sie aktuell 69 Glycyl-tRNA Synthetase (GARS) Antikörper von 17 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Glycyl-tRNA Synthetase Kits (17) und Glycyl-tRNA Synthetase Proteine (9) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 101 Glycyl-tRNA Synthetase Produkte verfügbar.
Synonyme:
Aat-gly, CG6778, CMT2D, Dmel\\CG6778, DSMAV, fb02f03, gars, GB13467, Gena201, GENA202, GlyRS, GRS, HMN5, MGC79495, Nmf249, RGD1559871, Sgrp23, si:dkey-276i5.1, SMAD1, team, wu:fb02f03

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Am meisten referenzierte anti-Glycyl-tRNA Synthetase Antikörper

  1. Human Polyclonal GARS Primary Antibody für WB - ABIN392465 : Shiba, Schimmel, Motegi, Noda: Human glycyl-tRNA synthetase. Wide divergence of primary structure from bacterial counterpart and species-specific aminoacylation. in The Journal of biological chemistry 1994 (PubMed)
    Zeige alle 2 Referenzen für 392465

  2. Human Polyclonal GARS Primary Antibody für EIA, WB - ABIN360353 : Antonellis, Ellsworth, Sambuughin, Puls, Abel, Lee-Lin, Jordanova, Kremensky, Christodoulou, Middleton, Sivakumar, Ionasescu, Funalot, Vance, Goldfarb, Fischbeck, Green: Glycyl tRNA synthetase mutations in Charcot-Marie-Tooth disease type 2D and distal spinal muscular atrophy type V. in American journal of human genetics 2003 (PubMed)
    Zeige alle 2 Referenzen für 360353

  3. Cow (Bovine) Polyclonal GARS Primary Antibody für WB - ABIN2787816 : Förster, Zerressen-Harte, Fürste, Perbandt, Betzel, Erdmann: Comparative X-ray structure analysis of human and Escherichia coli tRNA(Gly) acceptor stem microhelices. in Biochemical and biophysical research communications 2008 (PubMed)

Weitere Antikörper gegen Glycyl-tRNA Synthetase Interaktionspartner

Fruit Fly (Drosophila melanogaster) Glycyl-tRNA Synthetase (GARS) Interaktionspartner

  1. Our findings suggest that mutant GlyRS gains access to ectopic sub-compartments of the motor neuron, providing a possible explanation for the selective neuropathology caused by mutations in a widely expressed gene.

Human Glycyl-tRNA Synthetase (GARS) Interaktionspartner

  1. At the active site, a glycyl-AMP (zeige APRT Antikörper) molecule is synthesized and is waiting for the transfer of the glycyl moiety to occur.

  2. GlyRS functions as a chaperone that critically supports neddylation.

  3. Data indicate that dimerization is required for the dominant neurotoxicity of disease-associated GARS mutations and provide a rapid, tractable model for studying newly identified GARS variants for a role in human disease.

  4. one of the mRNAs isoforms tightly controls expression and localization of human GARS.

  5. This study reports two crystal structures of human GlyRS variants, in the free form and in complex with tRNA(Gly) respectively, and reveal new aspects of the glycylation mechanism.

  6. GARS mutations are an uncommon cause of Charcot-Marie-Tooth Disease (CMT) in Taiwan. The p.Asp146Tyr and p.Met238Arg mutations are associated with early-onset axonal CMT.

  7. Our findings suggest that mutant GlyRS gains access to ectopic sub-compartments of the motor neuron, providing a possible explanation for the selective neuropathology caused by mutations in a widely expressed gene.

  8. Expression of three CMT-mutant GARS proteins in Drosophila induces defects in motor performance and motor and sensory neuron morphology, and shortens lifespan.

  9. The c.999G>T mutation is a novel mutation of the glycyl-tRNA synthetase gene that has not been previously reported. The phenotype of this family is Charcot-Marie-Tooth disease type 2D, which is first reported in Chinese population.

  10. we propose that the disease-causing L129P mutant of glycyl-tRNA synthetase is linked to a distribution defect in peripheral nerves in vivo.

Mouse (Murine) Glycyl-tRNA Synthetase (GARS) Interaktionspartner

  1. findings link the selective pathology of Charcot-Marie-Tooth disease type 2D to the neomorphic binding activity of GlyRS(CMT2D) that antagonizes the VEGF (zeige VEGFA Antikörper)-Nrp1 (zeige NRP1 Antikörper) interaction, meaning the VEGF (zeige VEGFA Antikörper)-Nrp1 (zeige NRP1 Antikörper) signalling axis is an actionable target for treating CMT2D

  2. Results indicate that Charcot-Marie-Tooth peripheral neuropathies, type 2D (CMT2D) phenotype is caused by novel pathogenic roles for the mutant GARS that specifically affect peripheral neurons.

  3. a glycyl-tRNA synthetase (GARS) mutation causes peripheral sensory and motor phenotypes creating a model of Charcot-Marie-Tooth type 2D peripheral neuropathy

  4. Gars(C201R) mutation significantly delayed disease onset in the SOD1 (zeige SOD1 Antikörper)(G93A);Gars(C201R/+) double heterozygous mutant mice and increased lifespan by 29% on the genetic background investigated

Zebrafish Glycyl-tRNA Synthetase (GARS) Interaktionspartner

  1. Data indicate that dimerization is required for the dominant neurotoxicity of disease-associated GARS mutations and provide a rapid, tractable model for studying newly identified GARS variants for a role in human disease.

Pig (Porcine) Glycyl-tRNA Synthetase (GARS) Interaktionspartner

  1. Expression levels of ADSL (zeige ADSL Antikörper), GARS-AIRS-GART (zeige GART Antikörper), and DGAT1 (zeige DGAT1 Antikörper) were higher in longissimus lumborum muscle than in heart or liver tissues

Glycyl-tRNA Synthetase (GARS) Antigen-Profil

Beschreibung des Gens

This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.

Alternative names and synonyms associated with Glycyl-tRNA Synthetase (GARS)

  • Glycyl-tRNA synthetase (Aats-gly) Antikörper
  • glycyl-tRNA synthetase (Aats-gly) Antikörper
  • glycyl-tRNA synthetase (GARS) Antikörper
  • glycyl-tRNA synthetase (gars) Antikörper
  • glycyl-tRNA synthetase (glyQ) Antikörper
  • glycyl-tRNA synthetase (TTHA0543) Antikörper
  • glycyl-tRNA synthetase (Gars) Antikörper
  • glycyl-tRNA synthetase (LOC692991) Antikörper
  • glycyl-tRNA synthetase-like (LOC100512260) Antikörper
  • Aat-gly Antikörper
  • CG6778 Antikörper
  • CMT2D Antikörper
  • Dmel\\CG6778 Antikörper
  • DSMAV Antikörper
  • fb02f03 Antikörper
  • gars Antikörper
  • GB13467 Antikörper
  • Gena201 Antikörper
  • GENA202 Antikörper
  • GlyRS Antikörper
  • GRS Antikörper
  • HMN5 Antikörper
  • MGC79495 Antikörper
  • Nmf249 Antikörper
  • RGD1559871 Antikörper
  • Sgrp23 Antikörper
  • si:dkey-276i5.1 Antikörper
  • SMAD1 Antikörper
  • team Antikörper
  • wu:fb02f03 Antikörper

Bezeichner auf Proteinebene für GARS

Aats-gly-PA , Aats-gly-PB , Aats-gly-PC , CG6778-PA , CG6778-PB , CG6778-PC , glycyl-tRNA synthetase , glycine--tRNA ligase , AP-4-A synthetase , Charcot-Marie-Tooth neuropathy 2D , Charcot-Marie-Tooth neuropathy, neuronal type, D , diadenosine tetraphosphate synthetase , glycine tRNA ligase , glyRS , storage granule protein 23 , glycyl-tran synthetase

GENE ID SPEZIES
39644 Drosophila melanogaster
408392 Apis mellifera
463329 Pan troglodytes
475268 Canis lupus familiaris
493218 Xenopus (Silurana) tropicalis
884595 Chlamydia trachomatis D/UW-3/CX
3169948 Thermus thermophilus HB8
100388470 Callithrix jacchus
2617 Homo sapiens
353172 Mus musculus
297113 Rattus norvegicus
337230 Danio rerio
446482 Xenopus laevis
428403 Gallus gallus
408010 Bos taurus
692991 Bombyx mori
100174405 Pongo abelii
100512260 Sus scrofa
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