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mir (zeige MLXIP ELISA Kits)-122 and its targets G6PC3 (zeige G6PC3 ELISA Kits), ALDOA and CS play roles in the hypoxia responses that regulate glucose and energy metabolism and can serve as hypoxia biomarkers.
Aldolase (zeige ALD ELISA Kits) A promotes lung cancer metastasis via PHD (zeige PDC ELISA Kits)-mediated stabilization of HIF-1alpha (zeige HIF1A ELISA Kits) and the subsequent activation of MMP9 (zeige MMP9 ELISA Kits).
Findings show that ALDOA expression is up-regulated in colorectal cancer (CRC (zeige CALR ELISA Kits)) and is a hypoxia-inducible prognostic factor that is closely related to CRC (zeige CALR ELISA Kits) malignancy.
Overexpression of ALDOA is associated with colorectal cancer.
In vitro and in vivo results demonstrated that ALDOA was associated with proliferation and metastasis of pancreatic cancer cells.
Study shows that PI3K (zeige PIK3CA ELISA Kits) directly coordinates glycolysis with cytoskeletal dynamics in an AKT (zeige AKT1 ELISA Kits)-independent manner. Growth factors or insulin (zeige INS ELISA Kits) stimulate the PI3K (zeige PIK3CA ELISA Kits)-dependent activation of Rac (zeige AKT1 ELISA Kits), leading to disruption of the actin cytoskeleton, release of filamentous actin-bound aldolase (zeige ALD ELISA Kits) A, and an increase in aldolase (zeige ALD ELISA Kits) activity.
Our results expand the clinical spectrum of aldolase (zeige ALD ELISA Kits) A deficiency to isolated temperature-dependent rhabdomyolysis, and suggest that thermolability may be tissue specific. We also propose a treatment for this severe disease
Study provides evidence supporting a critical functional role of ALDOA in osteosarcoma progression, metastasis and perhaps chemoresistance.
ALDOC (zeige ALDOC ELISA Kits), Aldolase (zeige ALD ELISA Kits) A (ALDOA) and Aldolase B (zeige ALDOB ELISA Kits) (ALDOB (zeige ALDOB ELISA Kits)) activate Wnt (zeige WNT2 ELISA Kits) signaling.
ALDOA is highly expressed in lung squamous cell carcinoma (LSCC) and its expression level is correlated with LSCC metastasis, grades, differentiation status and poor prognosis.
The lattice of muscle aldolase (zeige ALD ELISA Kits) contacts corresponded to an increased number of interactions between high-entropy side chains that mitigate the lattice strain incurred upon cryocooling and accompanying mosaic spread increases.
kinetic and structural analyses of fructose-bisphosphate aldolase (zeige FDA ELISA Kits)
The results presented here point to ALDA as a factor involved in the regulation of cells proliferation.
Aldolase inhibits WASP/Arp2/3-dependent actin polymerization in vitro
The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10.
fructose-bisphosphate aldolase A
, aldolase A, fructose-bisphosphate
, aldolase C
, fructose-1,6-bisphosphate triosephosphate-lyase
, lung cancer antigen NY-LU-1
, muscle-type aldolase
, aldolase 1, A isoform