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In an in vitro assay of vascular smooth muscle cells, circRNA WDR77 silencing significantly inhibited cell proliferation and migration. Bioinformatics methods revealed that miR (zeige MLXIP ELISA Kits)-124 and fibroblast growth factor 2 (FGF-2 (zeige FGF2 ELISA Kits)) were downstream targets of circRNA WDR77.
SFN (zeige SFN ELISA Kits) treatment of tumors results in reduced MEP50 level and H4R3me2s formation, confirming that that SFN (zeige SFN ELISA Kits) impacts this complex in vivo. These studies suggest that the PRMT5 (zeige PRMT5 ELISA Kits)/MEP50 is required for tumor growth and that reduced expression of this complex is a part of the mechanism of SFN (zeige SFN ELISA Kits) suppression of tumor formation.
Results provide evidence that PRMT5 and p44 regulate gene expression of growth and anti-growth factors to promote lung tumorigenesis.
TSC22D2 protein might be a member of the PRMT5 (zeige PRMT5 ELISA Kits) complex via direct binding of WDR77.
MEP50 genes reduces gene expression through histone arginine methylation in keratinocytes.
MEP50 can transform cells independent of AR and ER.
Data indicate that MEP50 WD repeat protein (zeige DCAF7 ELISA Kits) is essential for methylation of histones H4 and H2A by PRMT5 (zeige PRMT5 ELISA Kits) arginine methyltransferase.
These findings characterize PKG (zeige PRKG1 ELISA Kits) as a novel regulator of AR-mediated transcription by enhancing AR cofactor p44/WDR77's function.
Data indicate a transcription complex androgen receptor (AR (zeige AR ELISA Kits))-p44 (zeige GTF2H2 ELISA Kits)-Smad1 (zeige GARS ELISA Kits), and confirmed for physical interaction by co-immunoprecipitaion.
These studies suggest a novel mechanism by which proliferation and differentiation of prostate epithelial cells are controlled by WDR77's location in the cell.
WDR77 expression is associated with E2F1 (zeige E2F1 ELISA Kits), E2F3, GATA2 (zeige GATA2 ELISA Kits) and GATA6 (zeige GATA6 ELISA Kits) occupancy on the WDR77 gene, whereas, in contrast, E2F6 (zeige E2F6 ELISA Kits), GATA1 (zeige GATA1 ELISA Kits) and GATA3 (zeige GATA3 ELISA Kits) occupancy is associated with the loss of WDR77 expression during erythroid maturation and lung development
Silencing p21(Cip1 (zeige CDKN1A ELISA Kits)) or NF-kappaB (zeige NFKB1 ELISA Kits) p65 (zeige NFkBP65 ELISA Kits) expression with short hairpin RNA (shRNA) abolished astrocyte activation and rescued the astrocyte growth inhibition induced by deletion of the p44/WDR77 gene.
Data indicate that MEP50 WD repeat protein (zeige DCAF7 ELISA Kits) is essential for methylation of histones H4 and H2A (zeige H2AFX ELISA Kits) by PRMT5 (zeige PRMT5 ELISA Kits) arginine methyltransferase.
Structure of MEP50/Wdr77 in the PRMT5 (zeige PRMT5 ELISA Kits)-MEP50 complex
Protein arginine methyltransferase Prmt5 (zeige PRMT5 ELISA Kits)-Mep50 methylates histones H2A (zeige H2AFX ELISA Kits) and H4 and the histone chaperone nucleoplasmin (zeige NPM1 ELISA Kits) in Xenopus laevis eggs
WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002
WD repeat-containing protein 77
, androgen receptor cofactor p44
, methylosome protein 50
, WD repeat domain 77
, methylosome protein 50-like