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DLP (zeige DMD ELISA Kits) and ASF1 are part of a predeposition complex, which is recruited by XNP (zeige ATRX ELISA Kits) and is necessary to prevent DNA exposure in the nucleus.
ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a (zeige ASF1A ELISA Kits) by TLK (zeige TLK2 ELISA Kits) kinases.
dASF1 has a direct role in modifying chromatin structure during DNA replication and this function of dASF1 is important for the processivity of the replication machinery.
Asf1 is directed via interactions with sequence-specific complexes to mediate silencing of specific target genes.
Histone chaperones ASF1 and NAP1 (zeige NAP1L1 ELISA Kits) differentially modulate removal of active histone marks by LID-RPD3 (zeige HDAC1 ELISA Kits) complexes during NOTCH (zeige NOTCH1 ELISA Kits) silencing.
high level of SF2, as a novel oncoprotein in RCC (zeige XRCC1 ELISA Kits), was significantly associated with poor survival in a large cohort of RCC (zeige XRCC1 ELISA Kits) specimens. Taken together, our study presents a road map for the prediction and validation of miR (zeige MLXIP ELISA Kits)-766-3p/SF2 axis and thus imparts a therapeutic way for further RCC (zeige XRCC1 ELISA Kits) progression.
The authors found that RNA recognition motif 1 (RRM1 (zeige RRM1 ELISA Kits)) in SRSF1 binds PP1 (zeige PPA1 ELISA Kits) and represses its catalytic function through an allosteric mechanism.
We present a joint atomistic molecular dynamics (MD) and experimental study of two RRM-containing proteins bound with their single-stranded target RNAs, namely the Fox-1 (zeige A2BP1 ELISA Kits) and SRSF1 complexes.The simulations predict unanticipated specific participation of Arg142 at the protein-RNA interface of the SRFS1 complex, which is subsequently confirmed by NMR and ITC measurements
Using NMR spectroscopy with two separately expressed domains of SRSF1, we showed that several residues in the RNA-binding motif 2 interact with the N-terminal region of the RS domain (RS1 (zeige RS1 ELISA Kits)).
Especially, in SRSF1 morphants, bone cartilage formation was reduced in the brain and Nkx-2.5 (zeige NKX2-5 ELISA Kits) expression was dramatically reduced in the heart of SRSF1 morphants. In addition, a dramatic reduction in functional chordin (zeige CHRD ELISA Kits) RNA in SRSF1 morphants was observed suggesting that chordin (zeige CHRD ELISA Kits) is one of the targets of SRSF1. Thus, we concluded that SRSF1 is an essential factor for pattern formation including heart, cartilage and germ lay
results strongly support SRSF1 as a prognostic biomarker in SCLC and provide a rationale for personalized therapy in SCLC
NSrp70 (zeige NSRP1 ELISA Kits) acts as a new molecular counterpart for alternative splicing of target RNA, counteracting SRSF1 and SRSF2 (zeige SRSF2 ELISA Kits) splicing activity.
we have identified for the first time a potential mechanism that involves the essential splicing factor (zeige SLU7 ELISA Kits) ASF/SF2 through which morphine regulates splicing specificity of the MOR (zeige OPRM1 ELISA Kits) encoding gene, OPRM1 (zeige OPRM1 ELISA Kits).
Global splicing analysis with RNA-seq revealed that exons carrying the hnRNP H (zeige HNRNPH1 ELISA Kits)-binding GGGGG motif are predisposed to be skipped compared to those carrying the SRSF1-binding GGAGG motif in both human and mouse brains.
We present experimental evidence that splicing factor (zeige SLU7 ELISA Kits) SRSF1, SRSF2 (zeige SRSF2 ELISA Kits), U2AF35 (zeige U2AF1 ELISA Kits), U2AF65 (zeige U2AF59 ELISA Kits) and KHSRP (zeige KHSRP ELISA Kits) expression levels in gastrointestinal tract (colon, gastric and pancreatic) tumors differ compare to healthy tissues and in cell lines
The expression levels of three splicing factors, ESRP1 (zeige ESRP1 ELISA Kits), PTB (zeige PTBP1 ELISA Kits) and SF2/ASF, are significantly altered during cardiac hypertrophy in mice.
RRP1B suppresses metastatic progression by altering the transcriptome through its interaction with splicing regulators such as SRSF1
Deletion of RRM1 (zeige RRM1 ELISA Kits) eliminated the splicing activity of SRSF1 and thus cellular transformation.
Specific effects on regulated splicing by SR proteins SRSF1 and SRSF2 (zeige SRSF2 ELISA Kits) depends on a complex set of relationships with multiple other SR proteins in mammalian genomes.
Treatment with IL-17 (zeige IL17A ELISA Kits) prolongs the half-life of chemokine (zeige CCL1 ELISA Kits) CXCL1 (zeige CXCL1 ELISA Kits) mRNA via the adaptor TRAF5 (zeige TRAF5 ELISA Kits) and the splicing-regulatory factor SF2 (ASF).
analysis of the miRNA-mediated interaction between leukemia/lymphoma-related factor (LRF (zeige ZBTB7A ELISA Kits)) and alternative splicing factor/splicing factor (zeige SLU7 ELISA Kits) 2 (ASF/SF2) affects cell senescence and apoptosis
Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 (zeige SMN1 ELISA Kits) causes spinal muscular atrophy in the absence of SMN1 (zeige SMN1 ELISA Kits)
Both hnRNP A1 (zeige HNRNPA1 ELISA Kits) and alternative splicing factor/splicing factor (zeige SLU7 ELISA Kits) 2 contents rose in adenomas and during injury-induced hyperplasia compared to control lungs
These results highlight the requirement of Sfrs1-mediated alternative splicing for the survival of retinal neurons, with sensitivity defined by the window of time in which the neuron was generated.
This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 13.
, anti- silencing function 1
, anti-silencing factor
, splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor)
, SR splicing factor 1
, alternative-splicing factor 1
, pre-mRNA-splicing factor SF2, P33 subunit
, splicing factor 2
, splicing factor, arginine/serine-rich 1
, splicing factor arginine/serine-rich 1
, splicing factor, arginine/serine-rich 1B
, pre-mRNA-splicing factor SRp30a
, splicing factor, arginine/serine-rich 1 (ASF/SF2)
, serine/arginine-rich splicing factor 1B
, splicing factor, arginine/serine-rich 1b