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The binding of laminin-1 (zeige LAMA1 ELISA Kits) to 67LR causes initial signaling through PKA and Epac (zeige RAPGEF3 ELISA Kits), which causes the internalization of 67LR, along with signaling enzymes, such as adenylyl cyclase, into early endosomes. This causes sustained signaling for protection against neuronal cell death induced by serum withdrawal.
We suggest that PrP(C (zeige PRNP ELISA Kits)) and its interactor, LR/37/67 kDa, could be potential therapeutic targets for schwannomas and other Merlin (zeige NF2 ELISA Kits)-deficient tumours.
Our results suggest that hypoxia-elicited c-Jun/activator protein 1 (zeige JUN ELISA Kits) regulates 37-kDa laminin receptor precursor expression, which modulates migration and invasion of lung adenocarcinoma cells
Increased LRP levels correlate with the increased invasive and adhesive potential in early and late stage melanoma cells.
A polysaccharide from Pinellia ternata inhibits cell proliferation and metastasis in human cholangiocarcinoma cells by targeting of Cdc42 (zeige CDC42 ELISA Kits) and 67kDa Laminin Receptor
67LR plays a considerable role in the development of colon cancer multidrug resistance
37LRP regulates the metastasis of glioma cells in vitro and tumor growth in vivo.
Higher molecular weight Rpsa requires sumoylation to form.
Knock-Down of the 37kDa (zeige LRRC17 ELISA Kits)/67kDa Laminin Receptor LRP/LR Impedes Telomerase Activity
Report discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasivness.
High 67-kDa laminin receptor expression is associated with obesity-induced inflammation.
Results indicate that MGr1-Ag/37LRP contributes to laminin-mediated cell adhesion-mediated drug resistance in gastric cancer cells.
a high plasticity of RPSA, which could be important for its multiple cellular localizations and functional interactions
Laminin receptor activation inhibits endothelial TF expression by impairing JNK (zeige MAPK8 ELISA Kits) phosphorylation
protective role of TGF-beta1 (zeige TGFB1 ELISA Kits)-dependent up-regulation of the 37/67 LR in cardiomyocytes in cardiac remodelling with increased laminin expression
Reduced expression of the TLR4 (zeige TLR4 ELISA Kits) signaling pathway involves both the 67-kDa laminin receptor and Toll-interacting protein Tollip (zeige TOLLIP ELISA Kits), leading to consequent inflammatory responses.
laminin receptor precursor protein interacts with doppel (zeige PRND ELISA Kits)
An N-terminally truncated laminin receptor mutant encompassing the extracellular domain reduces the binding of recombinant cellular huPrP to mouse neuroblastoma (zeige ARHGEF16 ELISA Kits) cells,and interferes with the PrP(Sc) propagation.
LamR plays a role in transduction by three other closely related serotypes (adeno (zeige ADORA2A ELISA Kits)-associated virus serotype 2 (AAV2), -3, and -9)
both eEF1A (zeige EEF1A2 ELISA Kits) and MYPT1 (zeige PPP1R12A ELISA Kits) have roles in EGCG signaling for cancer prevention through 67LR
These results indicate that LamR is a cellular attachment receptor for classical Swine Fever virus.
Dengue virus serotypes 1, 2 and 3 all interact with the 37 kDa/67 kDa laminin receptor (LAMR1), a common non-integrin surface protein on many cell types.
isolated a ribosomal protein SA cDNA that consists of 1064 bp with an open reading frame of 885 bp encoding a 295 aa protein
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
37 kDa laminin receptor
, 37/67 kDa laminin receptor
, 67 kDa laminin receptor
, Laminin receptor 1
, Laminin-binding protein precursor p40
, ribosomal protein SA
, 40S ribosomal protein SA
, laminin-binding protein precursor p40
, colon carcinoma laminin-binding protein
, laminin receptor 1 (67kD, ribosomal protein SA)
, multidrug resistance-associated protein MGr1-Ag
, 37 kDa oncofetal antigen
, P40-3, functional
, P40-8, functional
, laminin receptor 1 (ribosomal protein SA)
, 37kD Laminin receptor
, laminin receptor 1
, laminin receptor 1 (ribosomal protein SA, 67 kDA)
, ribosomal protein SA pseudogene
, laminin receptor