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Human Polyclonal RBM5 Primary Antibody für ICC, IF - ABIN4349633
Jackson, Du, Janesko-Feldman, Vagni, Dezfulian, Poloyac, Jackson, Clark, Kochanek: The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2015
RNA binding motif protein 10 (RBM10 (zeige RBM10 Antikörper)) negatively regulates its own mRNA and protein expression and that of RNA binding motif protein 5 (RBM5) by promoting alternative splicing-coupled nonsense-mediated mRNA decay (AS-NMD).
results provide evidence that RBM10 (zeige RBM10 Antikörper) expression, in RBM5-null tumors, may contribute to tumor growth and metastasis. Measurement of both RBM10 (zeige RBM10 Antikörper) and RBM5 expression in clinical samples may therefore hold prognostic and/or potentially predictive value
the mechanism of action of RBM5-AS1 (zeige PTGDR Antikörper) in the WNT (zeige WNT2 Antikörper) pathway via physical interactions with beta-catenin (zeige CTNNB1 Antikörper), helping organize transcriptional complexes that sustain colon cancer-initiating cells function.
Low RBM5 expression was significantly associated with gliomas.
RNA-binding motif 5 silencing reduced the messenger RNA and protein expression of the p53 (zeige TP53 Antikörper) target gene p21 (zeige CDKN1A Antikörper). Our results suggest that RNA-binding motif 5 downregulation is involved in gastric cancer progression and that RNA-binding motif 5 behaves as a tumor suppressor gene in gastric cancer
Results show that RBM5 is downregulated in smoke induced tumor; its overexpression inhibits tumor growth through cell cycle arrest and induction of apoptosis suggesting the importance of RBM5 in the pathogenesis of smoking-related cancer.
ICG-001 had no apparent effect on the RBM5 levels.
RBM5 knockdown in human neuronal cells decreases caspase activation by staurosporine.
Antagonizes the effects of RBM5, RBM6 (zeige RBM6 Antikörper), and RBM10 (zeige RBM10 Antikörper) in cell colony formation.
Loss of RBM5 expression is associated with lung adenocarcinoma.
Expression of Rbm5 and Rbm10 (zeige RBM10 Antikörper) RNA remained constant during C2C12 myogenesis, but protein levels significantly decreased.
The RBM5/10 staining was higher 48 to 72 hours after traumatic brain injury and appeared to be increased in neuronal nuclei (zeige RBFOX3 Antikörper) of the hippocampus.
Our findings also suggest that the second RRM of RBM5 is pivotal for appropriate pre-mRNA splicing.
This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer.
RNA binding motif protein 5
, RNA-binding motif protein 5-B
, RNA-binding protein 5-B
, RNA-binding motif protein 5
, RNA-binding protein 5
, RNA-binding protein 5-like
, RNA-binding motif protein 5-A
, RNA-binding protein 5-A
, putative tumor suppressor LUCA15
, renal carcinoma antigen NY-REN-9
, G15 protein
, tumor suppressor LUCA15