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Suggest that during heart disease nucleolin is reactivated to mobilize conserved aspects of chromatin remodeling and gene expression.
Disruption of the AtNUC-L1 gene induces loss of symmetrical DNA methylation (zeige HELLS ELISA Kits) without affecting histone epigenetic marks at rRNA genes.
PARL1 protein has roles similar to those of the yeast nucleolin in nuclear signal recognition, ribosomal processing, and ribosomal subunit accumulation.
NCL (zeige CLN5 ELISA Kits) was associated with bipolar disorder.
Nucleolin both forms an mRNP complex with the eIF4G (zeige EIF4G1 ELISA Kits) and CSF-1 (zeige CSF1 ELISA Kits) mRNA, and is co-localized with the eIF4G (zeige EIF4G1 ELISA Kits) in the cytoplasm further supporting nucleolin's role in translational regulation.
Identified the regulator of ribosome production nucleolin (NCL) as over-expressed in AML (zeige RUNX1 ELISA Kits) blasts. Moreover, we found in two series that high NCL (zeige CLN5 ELISA Kits) mRNA expression level was associated with a poor overall survival, particular in elderly patients.
Data suggest a 216-nucleotide proximal cis (zeige CISH ELISA Kits)-element in LIF (zeige LIF ELISA Kits) mRNA exhibits mRNA destabilizing potential; on exposure to carcinogen PMA (phorbol-12-myristate-13-acetate), this cis (zeige CISH ELISA Kits)-element exhibits mRNA stabilizing activity. PMA induces nucleo-cytoplasmic translocation of both nucleolin and PCBP1 (zeige PCBP1 ELISA Kits), 2 trans-acting factors that bind to and stabilize LIF (zeige LIF ELISA Kits) mRNA. [LIF (zeige LIF ELISA Kits) = leukemia inhibitory factor (zeige LIF ELISA Kits); PCBP1 (zeige PCBP1 ELISA Kits) = poly(rC) binding protein 1 (zeige PCBP1 ELISA Kits)]
Data suggest that C11orf98 microprotein, NPM1 (zeige NPM1 ELISA Kits), and nucleolin interact and colocalize in the cell nucleolus. (C11orf98 = chromosome 11 open reading frame 98 protein; NPM1 (zeige NPM1 ELISA Kits) = nucleophosmin 1 (zeige NPM1 ELISA Kits))
nucleolin inhibition is a new anti-pancreatic cancer therapeutic strategy that dually blocks tumor progression and normalizes tumor vasculature in pancreatic ductal adenocarcinoma
It has been found that during microtubule growth phases, nucleolin affects both the speed and life time of microtubule polymerization.
Interaction of Host Nucleolin with Influenza A Virus Nucleoprotein in the Early Phase of Infection Limits the Late Viral Gene Expression
A yeast display library based on an engineered IgG1 CH2 (zeige Acyp1 ELISA Kits) scaffold with diversified loop regions was constructed, and CH2 (zeige Acyp1 ELISA Kits) binders were isolated by panning against nucleolin.
A portion of HS-anMan colocalized with nucleolin at small discrete sites, while most of the nucleolin and nascent RNA was dispersed. In U87 cells, HS-anMan, nucleolin and nascent RNA reassembled after prolonged hypoxia.
Data indicate alpha-P85 (zeige ECM1 ELISA Kits) Subunit, PI-3K (p85alpha) as a positive regulator of epidermal growth factor receptor (EGFR (zeige EGFR ELISA Kits)) expression and cell malignant transformation via nucleolin-dependent mechanism.
Nucleolin protects macrophages from oxLDL-induced foam cell formation in hyperlipidemia through up-regulating ABCA1 (zeige ABCA1 ELISA Kits) expression.
Nucleolin Acts as a Scavenger Receptor for Acetylated Low-Density Lipoprotein on Macrophages
Nucleolin is a receptor for maleylated-bovine serum albumin (zeige ALB ELISA Kits) on macrophages
Lrrc34, a novel nucleolar protein (zeige MCRS1 ELISA Kits), interacts with npm1 (zeige GJA1 ELISA Kits) and ncl and has an impact on pluripotent stem cells
results indicate that nucleolin is a receptor that allows macrophages to recognize toxic Advanced glycosylation end-products.
results for the first time demonstrate that nucleolin-SUMO at K294R plays a critical role in its nucleus sequestration and gadd45alpha (zeige GADD45A ELISA Kits) mRNA binding activity.
Nucleolin-FGF1 interaction is critical for the intranuclear phosphorylation of FGF1 by PKCdelta and thereby the regulation of nuclear export of FGF1.
ANKRD1 (zeige ANKRD1 ELISA Kits), in association with factors such as nucleolin, represses MMP13 (zeige MMP13 ELISA Kits) transcription. Ankrd1 (zeige ANKRD1 ELISA Kits) deletion additionally relieved MMP10 (zeige MMP10 ELISA Kits) transcriptional repression
Data show that si-RNA induced down-regulation of FUT1 (zeige FUT1 ELISA Kits) and FUT2 (zeige FUT2 ELISA Kits) reduced expression of fucosylated nucleolin glycoforms and their exposure at the cell surface.
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20.
, eukaryotic translation initiation factor 3 subunit A
, Eukaryotic translation initiation factor 3 subunit 10
, nucleolin-like protein
, protein C23