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Studies indicate that nucleophosmin 1 (NPM1) has been considered as a promising target for the treatment of both haematologic and solid malignancies.
Work identifies the TP53 (zeige TP53 ELISA Kits) tumor suppressor as a novel target through which NPM1-RARA (zeige RARA ELISA Kits) impacts leukemogenesis.
These results suggested that relocation of NPM altered its interactional network and consequently disturbed the primary functions, including cell proliferation, adhesion, migration, and invasion. NPM plays a promotional role in cancer.
the consequence of mutations in NPM1 and possible mechanisms through which mutations lead to leukemogenesis (review0.
NPM1 mutation but not RUNX1 (zeige RUNX1 ELISA Kits) mutation or multilineage dysplasia defines a prognostic subgroup within de novo acute myeloid leukemia (zeige BCL11A ELISA Kits) lacking recurrent cytogenetic abnormalities
Nucleophosmin 1 (NPM1) mutations in chronic myelomonocytic leukemia and their prognostic relevance.
Multivariable analyses on time to relapse and OS revealed pre-transplant NPM1 MRD levels >1% as an independent prognostic factor for poor survival after allogeneic HSCT, whereas FLT3 (zeige FLT3 ELISA Kits)-ITD had no impact. Notably, outcome of patients with pre-transplant NPM1 MRD positivity >1% was as poor as that of patients transplanted with RD.
Our results indicate that CD4 (zeige CD4 ELISA Kits) expression and older age are adverse prognostic factors in wild-type NPM1, FLT3 (zeige FLT3 ELISA Kits)-ITD-negative CN-AML (zeige RUNX1 ELISA Kits).
NPM1-dependent nucleolar PIDDosome is a key initiator of the caspase-2 (zeige CASP2 ELISA Kits) activation cascade.
Data indicate that NPM-ALK (zeige ALK ELISA Kits) was distributed in equal amounts between the cytoplasm and the nucleus.
Results suggest that some polymorphisms in NPM1 are associated with body weight at some ages and may be used as candidates for marker-assisted selection and management in beef cattle breeding programmes.
The NPM1 gene is a candidate gene for growth traits in cattle.
molecular complementarity underlies the higher frequency and significantly worse prognosis associated with NPM1c/FLT3 (zeige FLT3 ELISA Kits)-internal tandem duplications vs NPM1 (zeige GJA1 ELISA Kits)/NRAS (zeige NRAS ELISA Kits)-G12D-mutant acute myeloid leukemia (zeige BCL11A ELISA Kits) (AML (zeige RUNX1 ELISA Kits)) and functionally confirm the role of HOXA genes in NPM1c-driven AML (zeige RUNX1 ELISA Kits).
NPM1 (zeige GJA1 ELISA Kits)-dependent nucleolar PIDDosome is a key initiator of the caspase-2 (zeige CASP2 ELISA Kits) activation cascade.
NPM1 (zeige GJA1 ELISA Kits) knockdown decreased NF-kappaB (zeige NFKB1 ELISA Kits)-mediated transcription of selected target genes by decreasing the recruitment of NF-kappaB (zeige NFKB1 ELISA Kits) p65 (zeige NFkBP65 ELISA Kits) to the gene promoters.
study suggests that although neurons need NPM1 (zeige GJA1 ELISA Kits) for survival, an increase in its expression beyond physiological levels and its translocation to the cytoplasm leads to death through abortive cell cycle induction.
The levels of B23 expression are directly regulated by EGR1 (zeige EGR1 ELISA Kits).
IDH2 (zeige IDH2 ELISA Kits) and NPM1 (zeige GJA1 ELISA Kits) mutations synergize in the development and maintenance of acute myeloid leukemia (zeige BCL11A ELISA Kits) stem-like cells.
Lrrc34, a novel nucleolar protein (zeige MCRS1 ELISA Kits), interacts with npm1 (zeige GJA1 ELISA Kits) and ncl (zeige NCL ELISA Kits) and has an impact on pluripotent stem cells
a function of NPM1 (zeige GJA1 ELISA Kits) in the spatial organization of nucleolus-associated heterochromatin through DNA methyltransferase (zeige DNMT1 ELISA Kits) DNMT3A (zeige DNMT3A ELISA Kits)
The data presented here support a novel role for NPM1 (zeige GJA1 ELISA Kits) as a multilevel modulator of the base excision repair pathway.
The mechanism of G-CSF's neuroprotection may be related in part to attenuating neuronal apoptosis by NPM1 (zeige GJA1 ELISA Kits).
NLP is essential for the positioning of centromeres during cell division in Drosophila.
This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
, nucleophosmin/nucleoplasmin, 4
, nucleolar protein NO38
, nucleophosmin/nucleoplasmin family, member 1
, nucleolar phosphoprotein B23
, nucleolar protein B23.1
, nucleophosmin 1
, chromatin decondensation protein 1