EIF2S1 Proteine (EIF2S1)

Bezeichnung:
Eukaryotic Translation Initiation Factor 2 Subunit 1 Proteine (EIF2S1)
Auf www.antikoerper-online.de finden Sie aktuell 19 Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen EIF2S1 Antikörper (134) und EIF2S1 Kits (1) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 162 EIF2S1 Produkte verfügbar.
Synonyme:
35kDa, 0910001O23Rik, 2410026C18Rik, CG9946, deIF2alpha, Dmel\\CG9946, EIF-2, eIF-2 a, eIF-2 alpha, EIF-2A, EIF-2alpha, EIF2, eIF2 alpha, eIF2-alpha, EIF2A, eIF2alpha, eif2s1, elF2alpha, fb19d01, IF2A_DROME, l(1)14Cf, l(1)19-153, M(1)8e3-10, M(1)14C, M(1)19-153, wu:fb19d01
alle Proteine anzeigen Gen GeneID UniProt
EIF2S1 13665 Q6ZWX6
EIF2S1 54318 P68101
EIF2S1 1965 P05198

Weitere Synonyme anzeigen

EIF2S1 Proteine (EIF2S1) nach Spezies

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Am meisten referenzierte EIF2S1 Proteine

  1. Human EIF2S1 Protein expressed in Escherichia coli (E. coli) - ABIN667786 : Boyce, Bryant, Jousse, Long, Harding, Scheuner, Kaufman, Ma, Coen, Ron, Yuan: A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. in Science (New York, N.Y.) 2005 (PubMed)
    Zeige alle 2 Referenzen für 667786

Weitere Proteine zu EIF2S1 Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) Interaktionspartner

  1. Therapeutic modulation of eIF2alpha phosphorylation rescues TDP-43 (zeige TARDBP Proteine) toxicity in amyotrophic lateral sclerosis disease models.

Mouse (Murine) Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) Interaktionspartner

  1. ER stress-induced increase in ATF4 (zeige ATF4 Proteine) and CHOP (zeige DDIT3 Proteine) expression is initiated by an increase in Atf4 (zeige ATF4 Proteine) and Chop (zeige DDIT3 Proteine) mRNA, which is also dependent upon eIF2alpha (zeige EIF2A Proteine) phosphorylation.

  2. Data indicate that 5xFAD-related pathologies do not necessarily require hyperphosphorylation of eIF2alpha (zeige EIF2A Proteine) to emerge.

  3. Endoplasmic reticulum stress suppressed CReP (zeige PPP1R15B Proteine) expression in an IRE1 alpha (zeige ERN1 Proteine)-dependent manner, which increased eIF2alpha (zeige EIF2A Proteine) phosphorylation and consequently attenuated protein synthesis.

  4. eIF2alphaP acts as a molecular switch that dictates either cell survival or death by activated Akt (zeige AKT1 Proteine) in response to oxidative stress.

  5. aberrant phosphorylation of eukaryotic initiation factor (zeige EIF4G1 Proteine)-2a (eIF2a (zeige EIF2A Proteine)) may induce synaptic failure and neurodegeneration through persistent translational inhibition of global protein synthesis.

  6. Alteration of protein homeostasis and eIF2alpha (zeige EIF2A Proteine) phosphorylation status by pathogenic huntingtin (zeige HTT Proteine) appears to be an important cause of striatal cell death.

  7. Data indicate that prolonged endoplasmic reticulum stress inhibits protein synthesis independently of translation initiation factor (zeige TIF1 Proteine) eIF2alpha (zeige EIF2A Proteine)-P.

  8. This study demonistrated that Genetic deletion of eIF2alpha (zeige EIF2A Proteine) kinase PERK (zeige EIF2AK3 Proteine) prevented enhanced phosphorylation of eIF2alpha (zeige EIF2A Proteine) and deficits in protein synthesis, synaptic plasticity and spatial memory in animal disease model of Alzheimer's disease.

  9. eIF2alpha (zeige EIF2A Proteine) phosphorylation in the context of the ER stress response plays a role in cell survival by counteracting the p53 (zeige TP53 Proteine)-mediated mitochondrial apoptosis in response to statins.

  10. eIF2a (zeige EIF2A Proteine) is hyperphosphorylated in the cortex of aged mice. Young human-ApoE4 targeted-replacement mice show increased p-eIF2a/eIF2a (zeige EIF2A Proteine) levels in both cortex and hippocampus.

Pig (Porcine) Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) Interaktionspartner

  1. In conclusion, the immediate-early (zeige JUN Proteine) IE180 protein of pseudorabies virus has the previously uncharacterized ability to suppress phosphorylation levels of the eukaryotic translation initiation factor (zeige EIF2A Proteine) eIF2alpha (zeige EIF2A Proteine).

Human Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) Interaktionspartner

  1. These data indicate that PERK (zeige EIF2AK3 Proteine) regulates radioresistance in oropharyngeal carcinoma through NF-kB activation-mediated phosphorylation of eIF2alpha (zeige EIF2A Proteine)

  2. The stem-loop of noncoding RNA 886 is structural feature not only critical for inhibiting PKR (zeige PKLR Proteine) autophosphorylation, but also the phosphorylation of its cellular substrate, EIF-2alpha.

  3. overexpression of eIF5 (zeige EIF5 Proteine) and 5MP induces translation of ATF4 (zeige ATF4 Proteine).

  4. Through pathway analysis it was suggested the involvement of eIF2 and mTOR (zeige FRAP1 Proteine) in host cells upon Chlamydia trachomatis infection.

  5. PERK (zeige EIF2AK3 Proteine)-eIF2alpha (zeige EIF2A Proteine)-ATF4 (zeige ATF4 Proteine) signaling pathway mediated by endoplasmic reticulum stress involved in osteoblast differentiation of periodontal ligament cells under cyclic mechanical force.

  6. EnR (zeige LARGE Proteine) stress assessed by expression of PERK (zeige EIF2AK3 Proteine) and p-eIF2alpha (zeige EIF2A Proteine) was significantly associated with tumor infiltrating lymphocytes (TILs) in HER2 (zeige ERBB2 Proteine)-positive breast cancer.

  7. we unravels a new miRs-based mechanism that helps maintain intracellular proteostasis and promote cell survival during ER stress through upregulation of miR (zeige MLXIP Proteine)-30b-5p and miR (zeige MLXIP Proteine)-30c-5p which target eIF2alpha (zeige EIF2A Proteine) and thereby inhibit the p-eIF2alpha (zeige EIF2A Proteine)/ATF4 (zeige ATF4 Proteine)/CHOP (zeige DDIT3 Proteine) pro-apoptotic pathway, identifying miR (zeige MLXIP Proteine)-30b-5p and miR (zeige MLXIP Proteine)-30c-5p as potentially new targets for anti-cancer therapies.

  8. Our work suggests that OLA1 (zeige OLA1 Proteine) is a novel translational GTPase (zeige RACGAP1 Proteine) and plays a suppressive role in translation and cell survival, as well as cancer growth and progression.

  9. a delay in eIF2-bound GTP (zeige AK3 Proteine) hydrolysis should occur. In this work, we reconstructed this situation and found that such a delay leads to the redistribution of initiation complexes in favor to downstream AUG codons.

  10. The reactive oxygen species-generating NADPH oxidase-4 (Nox4 (zeige NOX4 Proteine)) is induced downstream of ATF4 (zeige ATF4 Proteine), binds to a PP1 (zeige PPA1 Proteine)-targeting subunit GADD34 (zeige PPP1R15A Proteine) at the endoplasmic reticulum, and inhibits PP1 (zeige PPA1 Proteine) activity to increase eIF2alpha (zeige EIF2A Proteine) phosphorylation and ATF4 (zeige ATF4 Proteine) levels.

Cow (Bovine) Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) Interaktionspartner

  1. Caspase (zeige CASP3 Proteine)(s)-dependent proteolysis of molecular chaperones and eIF2alpha (zeige EIF2A Proteine) may be novel signaling pathways of apoptosis.

EIF2S1 Protein Überblick

Protein Überblick

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2\; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3\; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987

Alternative names and synonyms associated with EIF2S1

  • eukaryotic translation Initiation Factor 2alpha (eIF-2alpha)
  • eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa (eif2s1)
  • eukaryotic translation initiation factor 2 alpha subunit (LOC693063)
  • eukaryotic translation initiation factor 2 alpha subunit (CNI00230)
  • eukaryotic translation initiation factor 2 alpha subunit (THAPSDRAFT_105)
  • Eukaryotic translation initiation factor 2 subunit 1 (if2a)
  • eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa (LOC100339093)
  • eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa (LOC100350462)
  • eukaryotic translation initiation factor 2 subunit 1 (if2a)
  • eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa (EIF2S1)
  • eukaryotic translation initiation factor 2, subunit 1 alpha (Eif2s1)
  • eukaryotic translation initiation factor 2, subunit 1 alpha (LOC100155472)
  • eukaryotic translation initiation factor 2, subunit 1 alpha b (eif2s1b)
  • 35kDa Protein
  • 0910001O23Rik Protein
  • 2410026C18Rik Protein
  • CG9946 Protein
  • deIF2alpha Protein
  • Dmel\\CG9946 Protein
  • EIF-2 Protein
  • eIF-2 a Protein
  • eIF-2 alpha Protein
  • EIF-2A Protein
  • EIF-2alpha Protein
  • EIF2 Protein
  • eIF2 alpha Protein
  • eIF2-alpha Protein
  • EIF2A Protein
  • eIF2alpha Protein
  • eif2s1 Protein
  • elF2alpha Protein
  • fb19d01 Protein
  • IF2A_DROME Protein
  • l(1)14Cf Protein
  • l(1)19-153 Protein
  • M(1)8e3-10 Protein
  • M(1)14C Protein
  • M(1)19-153 Protein
  • wu:fb19d01 Protein

Bezeichner auf Proteinebene für EIF2S1

CG9946-PA , eIF-2alpha-PA , eukaryotic initiation factor 2alpha , eukaryotic translation initiation factor 2 , eukaryotic translation initiation factor 2alpha , minute (1) 14C , EIF-2A , EIF-2alpha , eIF-2-alpha , eukaryotic translation initiation factor 2 subunit 1 , eukaryotic translation initiation factor 2 subunit alpha , eukaryotic translation initiation factor 2 alpha subunit , Eukaryotic translation initiation factor 2 subunit 1 , eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa , eIF-2A , eIF-2alpha , eukaryotic translation initiation factor 2A , eIF2 alpha subunit , eukaryotic translation initiation factor 2, subunit 1 (alpha )

GENE ID SPEZIES
32617 Drosophila melanogaster
448087 Xenopus (Silurana) tropicalis
693063 Bombyx mori
3259501 Cryptococcus neoformans var. neoformans JEC21
7449310 Thalassiosira pseudonana CCMP1335
100195154 Salmo salar
100339093 Oryctolagus cuniculus
100350462 Oryctolagus cuniculus
100528138 Ictalurus punctatus
100587728 Nomascus leucogenys
13665 Mus musculus
54318 Rattus norvegicus
100155472 Sus scrofa
321564 Danio rerio
1965 Homo sapiens
380444 Xenopus laevis
423279 Gallus gallus
480361 Canis lupus familiaris
327694 Bos taurus
100174029 Pongo abelii
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