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The in vitro assays demonstrate the binding of the C-terminus of AtGCN2 to uncharged tRNA molecules and the enzymatic activities of AtGCN2 on both eIF2alpha homologues in A. thaliana.
Results mechanistically link multiple forms of dystonia and put forth a new overall cellular mechanism for dystonia pathogenesis, impairment of eIF2alpha signaling, a pathway known for its roles in cellular stress responses and synaptic plasticity.
Stress-resistant translation of c-Src (zeige SRC Proteine) mRNA is mediated by eIF2A (zeige EIF2S1 Proteine).
GHRH (zeige GHRH Proteine) and GHRH-R (zeige GHRHR Proteine) loops are involved in placental choriocarcinoma cell line viability and apoptosis through Akt (zeige AKT1 Proteine) and eIF2a (zeige EIF2S1 Proteine) pathways.
These findings suggest that phosphorylated-eIF2alpha regulates synaptic actions of nicotine in both mice and humans, and that reduced phosphorylated-eIF2alpha may enhance susceptibility to nicotine (and other drugs of abuse) during adolescence.
The results suggest that dephosphorylation of eIF2a (zeige EIF2S1 Proteine) by GADD34 (zeige PPP1R15A Proteine) plays an important role in doxorubicin resistance of MCF-7/ADR (zeige AKR1B1 Proteine) cells.
The Newcastle disease virus-induced translation shutoff at late infection times was attributed to sustaining phosphorylation of eIF2a (zeige EIF2S1 Proteine), which is mediated by continual activation of PKR (zeige PKLR Proteine) and degradation of PP1 (zeige PPA1 Proteine).
We identified EIF2A (zeige EIF2S1 Proteine) phosphorylation as a novel early molecular event occurring in response to NAMPT (zeige NAMPT Proteine) inhibition and mediating protein synthesis arrest.
These experiments connect embryonic stem cell growth factors to eIF2alpha phosphorylation.
analysis of the ER stress response in immunogenic cell death and the potential value of eIF2alpha phosphorylation as a biomarker for this clinically relevant variant of apoptosis [review]
The data highlight independent interactions of PP1 (zeige PPA1 Proteine) and eIF2alpha with GADD34 (zeige PPP1R15A Proteine), demonstrating that GADD34 (zeige PPP1R15A Proteine) functions as a scaffold both in vitro and in cells
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a phosphorylation by inhibiting PPP1CA (zeige PPP1CA Proteine) via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (zeige ATF4 Proteine) expression. (eIF2a = eukaryotic initiation factor-2alpha (zeige EIF2S1 Proteine); PPP1CA (zeige PPP1CA Proteine) = protein phosphatase 1 catalytic subunit alpha; Atf4 (zeige ATF4 Proteine) = activating transcription factor 4 (zeige ATF4 Proteine))
ER stress-induced increase in ATF4 (zeige ATF4 Proteine) and CHOP (zeige DDIT3 Proteine) expression is initiated by an increase in Atf4 (zeige ATF4 Proteine) and Chop (zeige DDIT3 Proteine) mRNA, which is also dependent upon eIF2alpha phosphorylation.
The eIF2A knock out mice strain is viable and to date displays no apparent phenotype.
Thus, during addiction, cocaine hijacks translational control by p-eIF2alpha, initiating synaptic potentiation and addiction-related behaviors.
in mouse skeletal muscle stem cells, general repression of translation, mediated by the phosphorylation of translation initiation factor (zeige TIF1 Proteine) eIF2alpha at serine 51 (P-eIF2alpha), is required to maintain the quiescent state
Skeletal muscle-specific (zeige EIF3K Proteine) eukaryotic translation initiation factor 2alpha (zeige EIF2S1 Proteine) phosphorylation controls amino acid metabolism and fibroblast growth factor 21 (zeige FGF21 Proteine)-mediated non-cell-autonomous energy metabolism.
PGRN (zeige GRN Proteine) is a key regulator of insulin (zeige INS Proteine) resistance and PGRN (zeige GRN Proteine) may mediate its effects, at least in part, by inducing ER stress via the PERK (zeige EIF2AK3 Proteine)-eIF2alpha dependent pathway
The CARE-LUC mouse model represents an innovative tool to investigate the eIF2alpha-ATF4 (zeige ATF4 Proteine) axis and to develop drugs targeting this important pathway in the remediation of related pathologies.
Both DrPKZ-A and DrPKZ-B isoforms functionally interact with eIF2alpha and inhibit protein synthesis in Danio rerio.
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002
65 kDa eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
, eukaryotic translation initiation factor 2 subunit 1
, eukaryotic translation initiation factor 2 subunit alpha
, Eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A, 65kDa
, eukaryotic translation initiation factor
, eukaryotic translation initiation factor 2A-like
, GTP-exchange protein
, eIF-2B GDP-GTP exchange factor subunit alpha
, translation initiation factor eIF-2B subunit alpha