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The in vitro assays demonstrate the binding of the C-terminus of AtGCN2 to uncharged tRNA molecules and the enzymatic activities of AtGCN2 on both eIF2alpha homologues in A. thaliana.
This review consolidates current information regarding eIF2alpha phosphorylation in neurons and its impact in neurodegenerative diseases.
Results mechanistically link multiple forms of dystonia and put forth a new overall cellular mechanism for dystonia pathogenesis, impairment of eIF2alpha signaling, a pathway known for its roles in cellular stress responses and synaptic plasticity.
Stress-resistant translation of c-Src (zeige SRC Proteine) mRNA is mediated by eIF2A (zeige EIF2S1 Proteine).
GHRH (zeige GHRH Proteine) and GHRH-R (zeige GHRHR Proteine) loops are involved in placental choriocarcinoma cell line viability and apoptosis through Akt (zeige AKT1 Proteine) and eIF2a (zeige EIF2S1 Proteine) pathways.
These findings suggest that phosphorylated-eIF2alpha regulates synaptic actions of nicotine in both mice and humans, and that reduced phosphorylated-eIF2alpha may enhance susceptibility to nicotine (and other drugs of abuse) during adolescence.
The results suggest that dephosphorylation of eIF2a (zeige EIF2S1 Proteine) by GADD34 (zeige PPP1R15A Proteine) plays an important role in doxorubicin resistance of MCF-7/ADR (zeige AKR1B1 Proteine) cells.
The Newcastle disease virus-induced translation shutoff at late infection times was attributed to sustaining phosphorylation of eIF2a, which is mediated by continual activation of PKR and degradation of PP1.
We identified EIF2A (zeige EIF2S1 Proteine) phosphorylation as a novel early molecular event occurring in response to NAMPT (zeige NAMPT Proteine) inhibition and mediating protein synthesis arrest.
These experiments connect embryonic stem cell growth factors to eIF2alpha phosphorylation.
analysis of the ER stress response in immunogenic cell death and the potential value of eIF2alpha phosphorylation as a biomarker for this clinically relevant variant of apoptosis [review]
Caspase (zeige CASP3 Proteine)(s)-dependent proteolysis of molecular chaperones and eIF2alpha may be novel signaling pathways of apoptosis.
stress granule formation is a downstream event of eIF2alpha phosphorylation that may not directly protect cells from apoptosis, at least in spermatocytes of seminiferous tubules in early stages.
results further extended the understanding of Heme-regulated eIF2alpha kinase on the regulation of non-erythroid lineages and might provide new aspects for preventing and treating Cd-induced detrimental effects
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a phosphorylation by inhibiting PPP1CA (zeige PPP1CA Proteine) via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (zeige ATF4 Proteine) expression. (eIF2a = eukaryotic initiation factor-2alpha (zeige EIF2S1 Proteine); PPP1CA (zeige PPP1CA Proteine) = protein phosphatase 1 catalytic subunit alpha; Atf4 (zeige ATF4 Proteine) = activating transcription factor 4 (zeige ATF4 Proteine))
The eIF2A knock out mice strain is viable and to date displays no apparent phenotype.
Thus, during addiction, cocaine hijacks translational control by p-eIF2alpha, initiating synaptic potentiation and addiction-related behaviors.
in mouse skeletal muscle stem cells, general repression of translation, mediated by the phosphorylation of translation initiation factor (zeige TIF1 Proteine) eIF2alpha at serine 51 (P-eIF2alpha), is required to maintain the quiescent state
Skeletal muscle-specific (zeige EIF3K Proteine) eukaryotic translation initiation factor 2alpha (zeige EIF2S1 Proteine) phosphorylation controls amino acid metabolism and fibroblast growth factor 21 (zeige FGF21 Proteine)-mediated non-cell-autonomous energy metabolism.
PGRN (zeige GRN Proteine) is a key regulator of insulin (zeige INS Proteine) resistance and PGRN (zeige GRN Proteine) may mediate its effects, at least in part, by inducing ER stress via the PERK (zeige EIF2AK3 Proteine)-eIF2alpha dependent pathway
Both DrPKZ-A and DrPKZ-B isoforms functionally interact with eIF2alpha and inhibit protein synthesis in Danio rerio.
In conclusion, the immediate-early (zeige JUN Proteine) IE180 protein of pseudorabies virus has the previously uncharacterized ability to suppress phosphorylation levels of the eukaryotic translation initiation factor eIF2alpha.
Therapeutic modulation of eIF2alpha (zeige EIF2S1 Proteine) phosphorylation rescues TDP-43 (zeige TARDBP Proteine) toxicity in amyotrophic lateral sclerosis disease models.
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002
65 kDa eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2 subunit 1
, eukaryotic translation initiation factor 2 subunit alpha
, Eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A, 65kDa
, eukaryotic translation initiation factor
, eukaryotic translation initiation factor 2A-like
, eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
, eukaryotic initiation factor 2alpha
, eukaryotic translation initiation factor 2
, eukaryotic translation initiation factor 2alpha
, minute (1) 14C