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The in vitro assays demonstrate the binding of the C-terminus of AtGCN2 to uncharged tRNA molecules and the enzymatic activities of AtGCN2 on both eIF2alpha homologues in A. thaliana.
Results mechanistically link multiple forms of dystonia and put forth a new overall cellular mechanism for dystonia pathogenesis, impairment of eIF2alpha signaling, a pathway known for its roles in cellular stress responses and synaptic plasticity.
Stress-resistant translation of c-Src (zeige SRC ELISA Kits) mRNA is mediated by eIF2A (zeige EIF2S1 ELISA Kits).
GHRH (zeige GHRH ELISA Kits) and GHRH-R (zeige GHRHR ELISA Kits) loops are involved in placental choriocarcinoma cell line viability and apoptosis through Akt (zeige AKT1 ELISA Kits) and eIF2a (zeige EIF2S1 ELISA Kits) pathways.
These findings suggest that phosphorylated-eIF2alpha regulates synaptic actions of nicotine in both mice and humans, and that reduced phosphorylated-eIF2alpha may enhance susceptibility to nicotine (and other drugs of abuse) during adolescence.
The results suggest that dephosphorylation of eIF2a (zeige EIF2S1 ELISA Kits) by GADD34 (zeige PPP1R15A ELISA Kits) plays an important role in doxorubicin resistance of MCF-7/ADR (zeige AKR1B1 ELISA Kits) cells.
The Newcastle disease virus-induced translation shutoff at late infection times was attributed to sustaining phosphorylation of eIF2a (zeige EIF2S1 ELISA Kits), which is mediated by continual activation of PKR (zeige PKLR ELISA Kits) and degradation of PP1 (zeige PPA1 ELISA Kits).
We identified EIF2A (zeige EIF2S1 ELISA Kits) phosphorylation as a novel early molecular event occurring in response to NAMPT (zeige NAMPT ELISA Kits) inhibition and mediating protein synthesis arrest.
These experiments connect embryonic stem cell growth factors to eIF2alpha phosphorylation.
analysis of the ER stress response in immunogenic cell death and the potential value of eIF2alpha phosphorylation as a biomarker for this clinically relevant variant of apoptosis [review]
The data highlight independent interactions of PP1 (zeige PPA1 ELISA Kits) and eIF2alpha with GADD34 (zeige PPP1R15A ELISA Kits), demonstrating that GADD34 (zeige PPP1R15A ELISA Kits) functions as a scaffold both in vitro and in cells
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a phosphorylation by inhibiting PPP1CA (zeige PPP1CA ELISA Kits) via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (zeige ATF4 ELISA Kits) expression. (eIF2a = eukaryotic initiation factor-2alpha (zeige EIF2S1 ELISA Kits); PPP1CA (zeige PPP1CA ELISA Kits) = protein phosphatase 1 catalytic subunit alpha; Atf4 (zeige ATF4 ELISA Kits) = activating transcription factor 4 (zeige ATF4 ELISA Kits))
ER stress-induced increase in ATF4 (zeige ATF4 ELISA Kits) and CHOP (zeige DDIT3 ELISA Kits) expression is initiated by an increase in Atf4 (zeige ATF4 ELISA Kits) and Chop (zeige DDIT3 ELISA Kits) mRNA, which is also dependent upon eIF2alpha phosphorylation.
The eIF2A knock out mice strain is viable and to date displays no apparent phenotype.
Thus, during addiction, cocaine hijacks translational control by p-eIF2alpha, initiating synaptic potentiation and addiction-related behaviors.
in mouse skeletal muscle stem cells, general repression of translation, mediated by the phosphorylation of translation initiation factor eIF2alpha at serine 51 (P-eIF2alpha), is required to maintain the quiescent state
Skeletal muscle-specific (zeige EIF3K ELISA Kits) eukaryotic translation initiation factor 2alpha (zeige EIF2S1 ELISA Kits) phosphorylation controls amino acid metabolism and fibroblast growth factor 21 (zeige FGF21 ELISA Kits)-mediated non-cell-autonomous energy metabolism.
PGRN (zeige GRN ELISA Kits) is a key regulator of insulin (zeige INS ELISA Kits) resistance and PGRN (zeige GRN ELISA Kits) may mediate its effects, at least in part, by inducing ER stress via the PERK (zeige EIF2AK3 ELISA Kits)-eIF2alpha dependent pathway
The CARE-LUC mouse model represents an innovative tool to investigate the eIF2alpha-ATF4 (zeige ATF4 ELISA Kits) axis and to develop drugs targeting this important pathway in the remediation of related pathologies.
Both DrPKZ-A and DrPKZ-B isoforms functionally interact with eIF2alpha and inhibit protein synthesis in Danio rerio.
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002
65 kDa eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
, eukaryotic translation initiation factor 2 subunit 1
, eukaryotic translation initiation factor 2 subunit alpha
, Eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A, 65kDa
, eukaryotic translation initiation factor
, eukaryotic translation initiation factor 2A-like
, GTP-exchange protein
, eIF-2B GDP-GTP exchange factor subunit alpha
, translation initiation factor eIF-2B subunit alpha