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alpha-Integrin expression and function modulates presentation of cell surface calreticulin (zeige CALR Proteine).
Although CALR (zeige CALR Proteine) mutations resulted in protein instability and proteosomal degradation, mutant CALR (zeige CALR Proteine) was able to enhance megakaryopoiesis and pro-platelet production from human CD34 (zeige CD34 Proteine)(+) progenitors.
Studies show that all CALR (zeige CALR Proteine) mutations generate frameshift mutation in the exon 9, which encodes the C-terminus end conferring a common mutant-specific sequence in all mutants. Mutant CALR (zeige CALR Proteine) constitutively activates MPL (zeige MPL Proteine) to induce cellular transformation. The interaction between the mutant CALR (zeige CALR Proteine) and MPL (zeige MPL Proteine) is achieved by the conformational change in the C-terminal allowing N-domain binding to MPL (zeige MPL Proteine). [review]
C-CALR (zeige CALR Proteine) in response to Ca2 (zeige CA2 Proteine)+ undergoes conformational changes that trigger its function to export GR from the nucleus, resetting the stress response of normal erythroid cells. Impairment of this function in JAK2V617F-positive erythroid cells maintains EPO-R (zeige EPOR Proteine) signaling in proliferation mode, contributing to erythrocytosis in PV.
Mannan-binding lectin (MBL (zeige MBL2 Proteine)) bound to T cells through interaction between the collagen-like region of MBL (zeige MBL2 Proteine) and calreticulin (CRT (zeige CALR Proteine)) expressed on the T-cell surface.
CRT exposure represents a novel powerful prognostic biomarker for patients with acute myeloid leukemia (zeige BCL11A Proteine).
In absence of CALR (zeige CALR Proteine), immature MPO (zeige MPO Proteine) protein precursors are degraded in the proteasome.
In patients with HD, a panel using calretinin and peripherin with or without MAP-2 may be most helpful in identifying transition zones
Coexisting mutations of the JAK2 (zeige JAK2 Proteine), CALR (zeige CALR Proteine), and MPL (zeige MPL Proteine) genes in myeloproliferative neoplasms suggest that CALR (zeige CALR Proteine) and MPL (zeige MPL Proteine) should be analyzed not only in JAK2 (zeige JAK2 Proteine)-negative patients but also in low V617F mutation patients.
CALR (zeige CALR Proteine)-mutated essential thrombocythemia (ET) patients harbored a higher mutant load at progenitor level than JAK2V617F-positive ET (HSCs: 39.9% vs 7.5% p<0.001, hematopoietic stem cells)
study provides a model showing that the C-terminal of mutant CALR (zeige CALR Proteine) activated JAK (zeige JAK3 Proteine)-STAT (zeige STAT1 Proteine) signaling specifically downstream of MPL (zeige MPL Proteine) and may have a central role in CALR (zeige CALR Proteine)-induced myeloproliferative neoplasms
the results of this investigation provide the first molecular insights into the phospholipid binding site of calreticulin (zeige CALR Proteine) as a key anchor point for the cell surface expression of calreticulin (zeige CALR Proteine) on apoptotic cells
a profound impairment in calreticulin (zeige CALR Proteine) function when its lectin site was inactivated. Remarkably, inactivation of the polypeptide binding site had little impact. These findings indicate that the lectin-based mode of client interaction is the predominant contributor to the chaperone functions of calreticulin (zeige CALR Proteine) within the endoplasmic reticulum.
This essential role of calreticulin (zeige CALR Proteine) in nucleocytoplasmic communication competency ties its regulatory action with proficiency of cardiac myofibrillogenesis essential for proper cardiac development.
Study provides evidence that chronic stress activates calreticulin (zeige CALR Proteine) and might be one of the pathological mechanisms underlying the motor coordination and motor learning dysfunctions seen in social defeat mice.
This study for the first time revealed that increased CRT inhibited Fas (zeige FAS Proteine)/FasL (zeige FASL Proteine)-mediated neuronal cell apoptosis during the early stage of ischemic stroke, suggesting it to be a potential protector activated soon after ischemia-reperfusion injury
The findings highlight the importance of CALR (zeige CALR Proteine) in female reproduction and demonstrate that compromised CALR (zeige CALR Proteine) function leads to ovarian insufficiency and female infertility.
Calreticulin (zeige CALR Proteine) mediates vascular smooth muscle cell responses to injury through the regulation of collagen deposition and neointima formation.
CALR (zeige CALR Proteine) mutants are sufficient to induce thrombocytosis through MPL (zeige MPL Proteine) activation.
Thrombopoietin receptor (zeige MPL Proteine) activation by myeloproliferative neoplasm associated calreticulin (zeige CALR Proteine) mutants.
GSK3ss down-regulates the creatine transporter CreaT, an effect reversed by treatment with the antidepressant Lithium and by co-expression of PKB/Akt (zeige AKT1 Proteine).
Mammalian target of rapamycin (mTOR (zeige FRAP1 Proteine)) stimulates the creatine transporter SLC6A8 through mechanisms at least partially shared by the serum and glucocorticoid-inducible kinase SGK1 (zeige SGK1 Proteine).
The observations suggest that SGK1 (zeige SGK1 Proteine) regulates the creatine transporter SLC6A8 at least partially through phosphorylation and activation of PIKfyve (zeige PIKFYVE Proteine).
The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
, Sodium- and chloride-dependent creatine transporter 1
, sodium- and chloride-dependent creatine transporter 1-like
, Sicca syndrome antigen A (autoantigen Ro; calreticulin)
, endoplasmic reticulum resident protein 60
, sodium- and chloride-dependent creatine transporter 1
, choline transporter
, creatine transporter 1
, solute carrier family 6 member 8
, creatine transporter, solute carrier family 6, member 8
, solute carrier family 6, member 8
, creatine transporter SLC6A8