anti-PTF1A (PTF1A) Antikörper

Bezeichnung:
anti-Pancreas Specific Transcription Factor, 1a Antikörper (PTF1A)
Auf www.antikoerper-online.de finden Sie aktuell 132 Pancreas Specific Transcription Factor, 1a (PTF1A) Antikörper von 19 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PTF1A Kits (24) und PTF1A Proteine (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 170 PTF1A Produkte verfügbar.
Synonyme:
bHLHa29, PTF1, PTF1-p48, PTF1A, Ptf1a/p48, PTF1p48, si:zc142h2.2, XPtf1a, zgc:112216

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anti-Human PTF1A Antikörper:

anti-Mouse (Murine) PTF1A Antikörper:

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Am meisten referenzierte anti-PTF1A Antikörper

  1. Human Polyclonal PTF1A Primary Antibody für ELISA, WB - ABIN190768 : Pascual, Abasolo, Mingorance-Le Meur, Martínez, Del Rio, Wright, Real, Soriano: Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expression. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)
    Zeige alle 2 Referenzen für 190768

  2. Human Polyclonal PTF1A Primary Antibody für ELISA, WB - ABIN253175 : Bernardo, Cho, Mason, Docherty, Pedersen, Vallier, Docherty: Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells. in Stem cells (Dayton, Ohio) 2009 (PubMed)
    Zeige alle 2 Referenzen für 253175

  3. Cow (Bovine) Polyclonal PTF1A Primary Antibody für WB - ABIN2779701 : Yamada, Terao, Terashima, Fujiyama, Kawaguchi, Nabeshima, Hoshino: Origin of climbing fiber neurons and their developmental dependence on Ptf1a. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 (PubMed)

  4. Cow (Bovine) Polyclonal PTF1A Primary Antibody für WB - ABIN2777451 : McLellan, Langlands, Kealey: Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. in Gene expression patterns : GEP 2003 (PubMed)

Weitere Antikörper gegen PTF1A Interaktionspartner

Zebrafish Pancreas Specific Transcription Factor, 1a (PTF1A) Interaktionspartner

  1. Results highlight the possibility that Ptf1a may act as an important transcription factor for enteric neuron development.

  2. In ptf1a haploinsufficiency, more ptf1a-lineage-labeled cells are traced into the pancreatic Notch (zeige NOTCH1 Antikörper)-responsive cell and endocrine compartments. More reduction of ptf1a gene dosage converts pancreatic progenitor cells to non-pancreatic cell fates.

  3. Autoregulation of ptf1a is absolutely required for exocrine pancreas formation.

  4. Postembryonic antagonism of Ptf1a, a master regulator of pancreatic development and acinar cell fate specification, induced expression of endocrine genes including insulin (zeige INS Antikörper) in the exocrine compartment. Induced insulin (zeige INS Antikörper)+ cells are derived from acinar cells.

  5. The timing of Ptf1a expression suggests that it is involved in the very early stages or steps in the differentiation of amacrine cells, which can be seen to rapidly diversify into a large number of subtypes.

  6. Ptf1 function is inhibited by notch (zeige NOTCH1 Antikörper)

  7. We propose that low levels of Ptf1a promote endocrine fate, whereas high levels repress endocrine fate and promote exocrine fate.

  8. Exocrine differentiation and proliferation factor (exdpf) is a direct target gene of pancreas-specific transcription factor 1a (Ptf1a).

Xenopus laevis Pancreas Specific Transcription Factor, 1a (PTF1A) Interaktionspartner

  1. Xenopus Ptf1a is essential for the initial specification of both endocrine and exocrine cells during normal pancreas development.

  2. Ptf1a overexpression leads to an increased ratio of GABAergic subtypes among the whole amacrine and horizontal cell population, highlighting its instructive capacity to promote this specific subtype of inhibitory neurons

  3. analysis of the gene regulatory network activated by Ptf1a in early pancreas development;results revealed that Ptf1a regulates genes with a wide variety of functions, providing insight into the complexity of the regulatory network required for pancreas specification

Human Pancreas Specific Transcription Factor, 1a (PTF1A) Interaktionspartner

  1. Study describes the wide range of gene control by PTF1A that maintains the specific characteristics of pancreatic acinar cell identity and differentiation. PTF1A controls the pancreatic acinar transcription program by direct action at a thousand genes and in collaboration with other less cell type-restricted factors to ensure acinar cell homeostasis and to suppress other cell-type-specific programs.

  2. Data show isolated Pancreatic Aplasia Due to a Hypomorphic PTF1A Mutation

  3. The results of this study suggested Ptf1a-dependent cell-fate misspecification as a novel mechanism of human brainstem pathology.

  4. PTF1A enhancer mutations have been shown to cause neonatal diabetes associated with pancreatic agenesis

  5. Loss of Ptf1a alone is sufficient to induce acinar-to-ductal metaplasia, potentiate inflammation, and induce a KRAS-permissive, pancreatic ductal adenocarcinoma-like gene expression profile.

  6. The results of the present study do not support the hypothesis that high penetrant mutations in these regions of PTF1A are involved in the development of human VATER/VACTERL association or NTDs

  7. ata indicate that E3 ubiquitin ligase (zeige MUL1 Antikörper) thyroid hormone receptor (zeige THRA Antikörper)-interacting protein (zeige RIPK1 Antikörper) 12 (TRIP12 (zeige TRIP12 Antikörper)) promotes proteasomal degradation of pancreas transcription factor 1a (PTF1a)and regulates PTF1a activities.

  8. Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis.

  9. ICAT (zeige CTNNBIP1 Antikörper) is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression.

  10. ptf1a functions as a "pancreatic determiner".

Mouse (Murine) Pancreas Specific Transcription Factor, 1a (PTF1A) Interaktionspartner

  1. Ptf1a is regulated by active and repressive inputs integrated through multiple sequence elements within a highly conserved sequence downstream of the Ptf1a gene.

  2. the Tfap2a (zeige TFAP2A Antikörper) and Tfap2b (zeige TFAP2B Antikörper) transcription factors were identified as two major downstream effectors of Ptf1a.

  3. This study demonstrated that the transcription factor Ptf1a is capable of cell autonomously redirecting cortical pyramidal cell identity toward an inhibitory peptidergic fate.

  4. We provide strong evidence for spatiotemporally context-dependent activity of Ptf1a as a potent gain-of-function trigger of pro-pancreatic commitment.

  5. Data suggest the role of pancreas-specific transcription factor 1a (PTF1a) in pancreas development in directing differentiation of embryonic stem cells (ESCs (zeige NR2E3 Antikörper)) to endocrine cells.

  6. GABAergic inducing activity of Ascl1 (zeige ASCL1 Antikörper) requires the direct transcriptional regulation of Ptf1a.

  7. Ascl1 (zeige ASCL1 Antikörper) and Ptf1a directly regulate distinct homeodomain transcription factors that specify excitatory or inhibitory neuronal fates.

  8. These data identify Ptf1a as the first gene involved in the segregation of the cerebellum from the more ventral brainstem.

  9. The results of this study suggested that Ptf1a specify spatial identities of cerebellar neuron progenitors in the neuroepithelium, leading to appropriate production of GABAergic and glutamatergic neurons, respectively.

  10. The results support a model whereby Ptf1a directs distinct gene expression programs that are established by the interplay of chromatin accessibility, collaborating transcription factors, and the DNA motifs within tissue-specific regulatory enhancers.

PTF1A Antigen-Profil

Beschreibung des Gens

This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.

Alternative names and synonyms associated with PTF1A

  • pancreas specific transcription factor, 1a (PTF1A) Antikörper
  • pancreas specific transcription factor, 1a (ptf1a) Antikörper
  • pancreas specific transcription factor, 1a (Ptf1a) Antikörper
  • bHLHa29 Antikörper
  • PTF1 Antikörper
  • PTF1-p48 Antikörper
  • PTF1A Antikörper
  • Ptf1a/p48 Antikörper
  • PTF1p48 Antikörper
  • si:zc142h2.2 Antikörper
  • XPtf1a Antikörper
  • zgc:112216 Antikörper

Bezeichner auf Proteinebene für PTF1A

pancreas specific transcription factor, 1a , Ptfa , bHLH transcription factor p48 , pancreas transcription factor 1 subunit alpha , pancreas-specific transcription factor 1a , Pancreas-specific transcription factor 1a , transcription factor Ptf1a/p48 , class A basic helix-loop-helix protein 29 , class II bHLH protein PTF1A , exocrine pancreas-specific transcription factor p48 , p48 DNA-binding subunit of transcription factor PTF1 , pancreas transcription factor1 p48 subunit , PTF1-p48

GENE ID SPEZIES
742903 Pan troglodytes
368662 Danio rerio
100381084 Xenopus laevis
256297 Homo sapiens
608313 Canis lupus familiaris
19213 Mus musculus
117034 Rattus norvegicus
781540 Bos taurus
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