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the expansion of the PRAME family occurred in both autosomes and sex chromosomes
To investigate the impact of gene copy number variation on PRAME expression, plasma cells were sorted from 50 newly diagnosed multiple myeloma patients and 8 healthy volunteers to measure PRAME transcript levels and gene copy numbers by real-time quantitative polymerase chain reaction.
Tumor antigen PRAME is up-regulated by MZF1 in cooperation with DNA hypomethylation in melanoma cells.
Results support the potential utility of NY-ESO-1, PRAME, and MAGEA4 as targets for immunotherapy and as ancillary prognostic parameters in synovial sarcomas.
PRAME plays a role in preventing the invasion and metastasis of lung adenocarcinoma
PRAME is expressed in many primary and metastatic UMs (zeige TBX3 ELISA Kits), and about half of the metastatic UMs (zeige TBX3 ELISA Kits) coexpress PRAME and HLA class I (zeige MICA ELISA Kits).
PRAME is a downstream factor of SOX17 (zeige SOX17 ELISA Kits) and LIN28 (zeige LIN28A ELISA Kits) in regulating pluripotency and suppressing somatic/germ cell differentiation in primordial germ cells, germ cell neoplasia in situ, and seminomas.
In line with its roles in controlling cell growth, RPAME regulates multiple critical cell-growth related genes, including IGF1R (zeige IGF1R ELISA Kits) oncogene (zeige RAB1A ELISA Kits). IGF1R (zeige IGF1R ELISA Kits) up-regulation contributes to increase of cell growth upon the knockdown of PRAME.
This study demonstrates that PRAME functions as a tumor suppressor in breast cancer.
PRAME is an independent prognostic biomarker in Uveal melanoma , which identifies increased metastatic risk in patients with Class 1 or disomy 3 tumors.
Leukemias expressing high levels of PRAME had higher levels of cell death by regulating S100A4 (zeige S100A4 ELISA Kits)/p53 (zeige TP53 ELISA Kits) signaling.
This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.
preferentially expressed antigen in melanoma
, Opa-interacting protein OIP4
, cancer/testis antigen 130
, melanoma antigen preferentially expressed in tumors
, opa-interacting protein 4
, preferentially expressed antigen of melanoma