anti-Maus CRY2 Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended CRY2 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Cryptochrome 2 (Photolyase-Like) (CRY2) Antikörper
  • Cry2
  • Cry
  • GB10211
  • CRY2
  • AT-PHH1
  • ATCRY2
  • CRYPTOCHROME 2 APOPROTEIN
  • F19P19.14
  • F19P19_14
  • FHA
  • PHH1
  • cryptochrome 2
  • HCRY2
  • PHLL2
  • AV006279
  • D130054K12Rik
  • gCry2
  • cryptochrome 2 (photolyase-like)
  • cryptochrome 2
  • cryptochrome Cry2
  • cryptochrome-2-like
  • CRY2
  • Cry2
  • cry2
  • LOC100502533
  • LOC100224803
  • LOC509058
Epitop
AA 564-593, C-Term
22
6
3
3
3
2
2
1
1
1
1
1
1
Reaktivität
Human, Maus
56
27
10
2
2
2
2
2
2
2
1
1
1
1
Wirt
Kaninchen
52
9
Klonalität
Polyklonal
Konjugat
Dieser CRY2 Antikörper ist unkonjugiert
2
2
2
2
2
2
Applikation
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
52
31
23
12
12
3
2
2
2
1
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN390080
$ 324.50
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN3042760 IHC (p) WB Rabbit IgG AA 171-200, N-Term Anmelden zum Anzeigen Polyclonal
1 ABIN358614 EIA IHC (p) WB Rabbit Ig C-Term Anmelden zum Anzeigen Polyclonal 5
1 ABIN5534082 IHC (p) WB Rabbit Ig Fraction AA 564-593, C-Term Anmelden zum Anzeigen Polyclonal
1 ABIN1804963 IHC (p) WB Rabbit AA 564-593 Anmelden zum Anzeigen Polyclonal

General

Antigen Cryptochrome 2 (Photolyase-Like) (CRY2) Antikörper
Epitop AA 564-593, C-Term
(22), (6), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus
(56), (27), (10), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Wirt Kaninchen
(52), (9)
Klonalität (Klon)
Polyklonal   ( )
Konjugat Dieser CRY2 Antikörper ist unkonjugiert
(2), (2), (2), (2), (2), (2)
Applikation Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(52), (31), (23), (12), (12), (3), (2), (2), (2), (1), (1)
Pubmed 5 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-CRY2 Antikörper

Target Details CRY2 Anwendungsinformationen Handhabung Referenzen für anti-CRY2 Antikörper (ABIN390080) Bilder
Reinigung This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen This Cry2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 564-593 AA from the C-terminal region of human Cry2.
Klon RB1846
Isotyp Ig

Target Details CRY2

Produktdetails anti-CRY2 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-CRY2 Antikörper (ABIN390080) Bilder zurück nach oben
Antigen
Andere Bezeichnung Cry2 (CRY2 Antibody Abstract)
Hintergrund Various biochemical, physiological and behavioural processes display circadian rhythms controlled by an internal biological clock. The central gears?driving this clock appear to be composed of an autoregulatory transcription/posttranslation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function, in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.
Molekulargewicht 66946 Da
Gen-ID 1408
NCBI Accession NP_066940
Forschungsgebiet Translation Factors, Cell Cycle, Transcription Factors, Signaling, Cell Structure
Pathways Response to Water Deprivation, Protein targeting to Nucleus

Anwendungsinformationen

Produktdetails anti-CRY2 Antikörper Target Details CRY2 Handhabung Referenzen für anti-CRY2 Antikörper (ABIN390080) Bilder zurück nach oben
Applikationshinweise Suggested dilutions:
WB = 1:1000, IHC (p) = 1:50-100
Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-CRY2 Antikörper Target Details CRY2 Anwendungsinformationen Referenzen für anti-CRY2 Antikörper (ABIN390080) Bilder zurück nach oben
Format Liquid
Konzentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handhabung Avoid freeze-thaw cycles.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
Haltbarkeit 6 months

Referenzen für anti-CRY2 Antikörper (ABIN390080)

Produktdetails anti-CRY2 Antikörper Target Details CRY2 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Ozgur, Sancar: "Purification and properties of human blue-light photoreceptor cryptochrome 2." in: Biochemistry, Vol. 42, Issue 10, pp. 2926-32, 2003

Griffin, Staknis, Weitz: "Light-independent role of CRY1 and CRY2 in the mammalian circadian clock." in: Science (New York, N.Y.), Vol. 286, Issue 5440, pp. 768-71, 1999

van der Horst, Muijtjens, Kobayashi, Takano, Kanno, Takao, de Wit, Verkerk, Eker, van Leenen, Buijs, Bootsma, Hoeijmakers, Yasui: "Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms." in: Nature, Vol. 398, Issue 6728, pp. 627-30, 1999

Kobayashi, Kanno, Smit, van der Horst, Takao, Yasui: "Characterization of photolyase/blue-light receptor homologs in mouse and human cells." in: Nucleic acids research, Vol. 26, Issue 22, pp. 5086-92, 1999

Hsu, Zhao, Zhao, Kazantsev, Wang, Todo, Wei, Sancar: "Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins." in: Biochemistry, Vol. 35, Issue 44, pp. 13871-7, 1996

Bilder

Produktdetails anti-CRY2 Antikörper Target Details CRY2 Anwendungsinformationen Handhabung Referenzen für anti-CRY2 Antikörper (ABIN390080) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Cryptochrome 2 (Photolyase-Like) (CRY2) (AA 564-593), (C-Term) antibody (ABIN390080) Western blot analysis of hCry2-R579 (ABIN390080) in mouse liver tissue and HepG2 cell...
Immunohistochemistry (IHC) image for anti-Cryptochrome 2 (Photolyase-Like) (CRY2) (AA 564-593), (C-Term) antibody (ABIN390080) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...