anti-Human CRY2 Antikörper für Enzyme Immunoassay

Recommended CRY2 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Cryptochrome 2 (Photolyase-Like) (CRY2) Antikörper
  • Cry2
  • Cry
  • GB10211
  • CRY2
  • AT-PHH1
  • ATCRY2
  • CRYPTOCHROME 2 APOPROTEIN
  • F19P19.14
  • F19P19_14
  • FHA
  • PHH1
  • cryptochrome 2
  • HCRY2
  • PHLL2
  • AV006279
  • D130054K12Rik
  • gCry2
  • cryptochrome 2 (photolyase-like)
  • cryptochrome 2
  • cryptochrome Cry2
  • cryptochrome-2-like
  • CRY2
  • Cry2
  • cry2
  • LOC100502533
  • LOC100224803
  • LOC509058
Epitop
C-Term
22
6
4
3
3
2
2
1
1
1
1
1
1
Reaktivität
Human, Maus
56
27
10
2
2
2
2
2
2
2
1
1
1
1
Wirt
Kaninchen
52
9
Klonalität
Polyklonal
Konjugat
Dieser CRY2 Antikörper ist unkonjugiert
2
2
2
2
2
2
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
52
31
23
12
12
3
2
2
1
1
1
Hersteller
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Bilder

Produktnummer ABIN358614
$ 390.50
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN5541209 EIA IHC (p) Rabbit AA 579-593 Anmelden zum Anzeigen Polyclonal

General

Antigen Cryptochrome 2 (Photolyase-Like) (CRY2) Antikörper
Epitop C-Term
(22), (6), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus
(56), (27), (10), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Wirt Kaninchen
(52), (9)
Klonalität
Polyklonal
Konjugat Dieser CRY2 Antikörper ist unkonjugiert
(2), (2), (2), (2), (2), (2)
Applikation Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(52), (31), (23), (12), (12), (3), (2), (2), (1), (1), (1)
Pubmed 5 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-CRY2 Antikörper

Target Details CRY2 Anwendungsinformationen Handhabung Referenzen für anti-CRY2 Antikörper (ABIN358614) Bilder
Spezifität This antibody reacts to CRY2.
Reinigung Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human CRY2.
Isotyp Ig

Target Details CRY2

Produktdetails anti-CRY2 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-CRY2 Antikörper (ABIN358614) Bilder zurück nach oben
Antigen
Andere Bezeichnung Cryptochrome-2 (CRY2 Antibody Abstract)
Hintergrund Various biochemical, physiological and behavioural processes display circadian rhythms controlled by an internal biological clock. The central gears driving this clock appear to be composed of an autoregulatory transcription/posttranslation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function, in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.Synonyms: CRY2, KIAA0658
Gen-ID 1408
NCBI Accession NP_001120929
UniProt Q49AN0
Pathways Response to Water Deprivation, Protein targeting to Nucleus

Anwendungsinformationen

Produktdetails anti-CRY2 Antikörper Target Details CRY2 Handhabung Referenzen für anti-CRY2 Antikörper (ABIN358614) Bilder zurück nach oben
Applikationshinweise ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-CRY2 Antikörper Target Details CRY2 Anwendungsinformationen Referenzen für anti-CRY2 Antikörper (ABIN358614) Bilder zurück nach oben
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Referenzen für anti-CRY2 Antikörper (ABIN358614)

Produktdetails anti-CRY2 Antikörper Target Details CRY2 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Ozgur, Sancar: "Purification and properties of human blue-light photoreceptor cryptochrome 2." in: Biochemistry, Vol. 42, Issue 10, pp. 2926-32, 2003

Griffin, Staknis, Weitz: "Light-independent role of CRY1 and CRY2 in the mammalian circadian clock." in: Science (New York, N.Y.), Vol. 286, Issue 5440, pp. 768-71, 1999

van der Horst, Muijtjens, Kobayashi, Takano, Kanno, Takao, de Wit, Verkerk, Eker, van Leenen, Buijs, Bootsma, Hoeijmakers, Yasui: "Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms." in: Nature, Vol. 398, Issue 6728, pp. 627-30, 1999

Kobayashi, Kanno, Smit, van der Horst, Takao, Yasui: "Characterization of photolyase/blue-light receptor homologs in mouse and human cells." in: Nucleic acids research, Vol. 26, Issue 22, pp. 5086-92, 1999

Hsu, Zhao, Zhao, Kazantsev, Wang, Todo, Wei, Sancar: "Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins." in: Biochemistry, Vol. 35, Issue 44, pp. 13871-7, 1996

Bilder

Produktdetails anti-CRY2 Antikörper Target Details CRY2 Anwendungsinformationen Handhabung Referenzen für anti-CRY2 Antikörper (ABIN358614) zurück nach oben
Bilder des Herstellers
 image for anti-Cryptochrome 2 (Photolyase-Like) (CRY2) (C-Term) antibody (ABIN358614) anti-Cryptochrome 2 (Photolyase-Like) (CRY2) (C-Term) antibody
 image for anti-Cryptochrome 2 (Photolyase-Like) (CRY2) (C-Term) antibody (ABIN358614) anti-Cryptochrome 2 (Photolyase-Like) (CRY2) (C-Term) antibody (Image 2)