anti-Human CRY1 Antikörper für Enzyme Immunoassay

Recommended CRY1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Cryptochrome 1 (Photolyase-Like) (CRY1) Antikörper
  • cry1-A
  • CRY1
  • cry2
  • phll1
  • xCRY1
  • PHLL1
  • AU020726
  • AU021000
  • Phll1
  • ATCRY1
  • BLU1
  • BLUE LIGHT UNINHIBITED 1
  • CRYPTOCHROME 1 APOPROTEIN (BLUE LIGHT PHOTORECEPTOR
  • ELONGATED HYPOCOTYL 4
  • HY4
  • OOP2
  • OUT OF PHASE 2
  • T3H13.14
  • T3H13_14
  • cryptochrome 1
  • cryptochrome 1 (photolyase-like)
  • cryptochrome 1
  • LOC100384475
  • cryptochrome-1
  • cry1-A
  • CRY1
  • cry1
  • siu50817b
  • LOC100223409
  • LOC100347047
  • Cry1
Epitop
C-Term
25
6
6
4
4
3
3
3
2
1
1
1
1
Reaktivität
Human
65
19
10
4
3
2
2
2
2
2
1
1
1
1
Wirt
Kaninchen
50
21
3
Klonalität
Polyklonal
Konjugat
Dieser CRY1 Antikörper ist unkonjugiert
2
2
2
2
2
2
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
69
39
35
17
11
6
3
2
2
1
1
1
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN358613
$ 390.50
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN781975 EIA IF IHC (p) WB Mouse IgG1 Anmelden zum Anzeigen 4H4-1C4

General

Antigen Cryptochrome 1 (Photolyase-Like) (CRY1) Antikörper
Epitop C-Term
(25), (6), (6), (4), (4), (3), (3), (3), (2), (1), (1), (1), (1)
Reaktivität Human
(65), (19), (10), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Wirt Kaninchen
(50), (21), (3)
Klonalität
Polyklonal
Konjugat Dieser CRY1 Antikörper ist unkonjugiert
(2), (2), (2), (2), (2), (2)
Applikation Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(69), (39), (35), (17), (11), (6), (3), (2), (2), (1), (1), (1)
Pubmed 5 Publikationen vorhanden
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Produktdetails anti-CRY1 Antikörper

Target Details CRY1 Anwendungsinformationen Handhabung Referenzen für anti-CRY1 Antikörper (ABIN358613) Bilder
Spezifität This antibody reacts to CRY1.
Reinigung Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide C-terminal region of human Cry1.
Isotyp Ig

Target Details CRY1

Produktdetails anti-CRY1 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-CRY1 Antikörper (ABIN358613) Bilder zurück nach oben
Antigen
Andere Bezeichnung Cryptochrome-1 (CRY1 Antibody Abstract)
Hintergrund Various biochemical, physiological and behavioural processes display circadian rhythms controlled by an internal biological clock. The central gears driving this clock appear to be composed of an autoregulatory transcription/posttranslation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function, in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.Synonyms: CRY1, PHLL1
Gen-ID 1407, 9606
UniProt Q16526
Pathways Response to Water Deprivation, Proton Transport

Anwendungsinformationen

Produktdetails anti-CRY1 Antikörper Target Details CRY1 Handhabung Referenzen für anti-CRY1 Antikörper (ABIN358613) Bilder zurück nach oben
Applikationshinweise ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-CRY1 Antikörper Target Details CRY1 Anwendungsinformationen Referenzen für anti-CRY1 Antikörper (ABIN358613) Bilder zurück nach oben
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Referenzen für anti-CRY1 Antikörper (ABIN358613)

Produktdetails anti-CRY1 Antikörper Target Details CRY1 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Griffin, Staknis, Weitz: "Light-independent role of CRY1 and CRY2 in the mammalian circadian clock." in: Science (New York, N.Y.), Vol. 286, Issue 5440, pp. 768-71, 1999

van der Horst, Muijtjens, Kobayashi, Takano, Kanno, Takao, de Wit, Verkerk, Eker, van Leenen, Buijs, Bootsma, Hoeijmakers, Yasui: "Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms." in: Nature, Vol. 398, Issue 6728, pp. 627-30, 1999

Kobayashi, Kanno, Smit, van der Horst, Takao, Yasui: "Characterization of photolyase/blue-light receptor homologs in mouse and human cells." in: Nucleic acids research, Vol. 26, Issue 22, pp. 5086-92, 1999

van der Spek, Kobayashi, Bootsma, Takao, Eker, Yasui: "Cloning, tissue expression, and mapping of a human photolyase homolog with similarity to plant blue-light receptors." in: Genomics, Vol. 37, Issue 2, pp. 177-82, 1997

Hsu, Zhao, Zhao, Kazantsev, Wang, Todo, Wei, Sancar: "Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins." in: Biochemistry, Vol. 35, Issue 44, pp. 13871-7, 1996

Bilder

Produktdetails anti-CRY1 Antikörper Target Details CRY1 Anwendungsinformationen Handhabung Referenzen für anti-CRY1 Antikörper (ABIN358613) zurück nach oben
Bilder des Herstellers
 image for anti-Cryptochrome 1 (Photolyase-Like) (CRY1) (C-Term) antibody (ABIN358613) anti-Cryptochrome 1 (Photolyase-Like) (CRY1) (C-Term) antibody
 image for anti-Cryptochrome 1 (Photolyase-Like) (CRY1) (C-Term) antibody (ABIN358613) anti-Cryptochrome 1 (Photolyase-Like) (CRY1) (C-Term) antibody (Image 2)