GRIN2B Proteine (GRIN2B)

Bezeichnung:
Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B Proteine (GRIN2B)
Auf www.antikoerper-online.de finden Sie aktuell 10 Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen GRIN2B Antikörper (391) und GRIN2B Kits (22) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 432 GRIN2B Produkte verfügbar.
Synonyme:
AW490526, GluN2B, hNR3, MRD6, Nmdar2b, nr2b
alle Proteine anzeigen Gen GeneID UniProt
GRIN2B 2904 Q13224
Ratte GRIN2B GRIN2B 24410 Q00960
GRIN2B 14812 Q01097

Weitere Synonyme anzeigen

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Weitere Proteine zu GRIN2B Interaktionspartnern

Human Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) Interaktionspartner

  1. Results indicate that the GRIN2B single nucleotide polymorphisms rs890 might be associated with schizophrenia in the Chinese Han population.

  2. These in vivo changes reflect changes in glutamate transporter (zeige SLC1A1 Proteine) protein (zeige HNRNPU Proteine) in Huntington's disease (HD), mice and human HD post-mortem tissue. Furthermore, NAC was able to rescue (zeige GRIN1 Proteine)changes in key glutamate receptor proteins related to excitotoxicity in HD, including NMDAR2B.

  3. Genetic association of CYP2B6 (zeige CYP2B6 Proteine)*6 and GRIN2B (rs1019385 and rs1806191) single-nucleotide polymorphisms and ketamine-induced EP occurrence.

  4. most rare variants in GluN2A (zeige GRIN2A Proteine) were associated with epilepsy, whereas GluN2B variants were associated with intellectual disability with or without seizures

  5. In this review, mutations in GRIN2B were described as distributed throughout the entire gene in patients with neuropsychiatric and developmental disorders.

  6. Genetic variants were found in GluN2B from patients with neurological or psychiatric disorders resulting in reduced surface expression of GluN2B.

  7. Results found that GluN2B subunit-containing NMDARs were dominant in induced pluripotent stem cell-derived neurons and that tyrosine-protein kinase Fyn (zeige FYN Proteine) potentiated the function of GluN2B subunit-containing NMDARs.

  8. Multiple genetic variants in GRIN2B are jointly associated with gene expression, prefrontal function and behaviour during working memory (WM). These results support the role of GRIN2B genetic variants in WM prefrontal activity in human adults.

  9. Findings do not support a role for GRIN2B variants in altering response to clozapine in our sample of European patients with schizophrenia deemed resistant or intolerant to treatment

  10. both Arf6 (zeige ARF6 Proteine) activation through GluN2B-BRAG1 during early development and the transition from BRAG1- to BRAG2 (zeige IQSEC1 Proteine)-dependent Arf6 (zeige ARF6 Proteine) signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses.

Mouse (Murine) Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) Interaktionspartner

  1. HumanTau(AT) causes excitotoxicity mediated by NR2B-containing NMDA receptors due to enhanced extracellular glutamate (zeige GRIN1 Proteine).

  2. The NR2B-CREB (zeige CREB1 Proteine)-miR212/132-CRTC1 (zeige CRTC1 Proteine)-CREB (zeige CREB1 Proteine) signal network plays an important role in the regulation of pain.

  3. This study demonstrated that Increasing the GluN2A (zeige GRIN2A Proteine)/GluN2B Ratio in Neurons of the Mouse Basal and Lateral Amygdala Inhibits the Modification of an Existing Fear Memory Trace.

  4. These in vivo changes reflect changes in glutamate transporter (zeige SLC1A1 Proteine) protein (zeige LAPTM4A Proteine) in HD mice and human HD post-mortem tissue. Furthermore, NAC was able to rescue changes in key glutamate (zeige GRIN1 Proteine) receptor proteins related to excitotoxicity in HD, including NMDAR2B.

  5. Data show that hydroxyproline HyP (zeige PHEX Proteine)(10) plays a critical role in maintaining the structural integrity of conantokins conRl-B, which can be correlated with its glutamate (zeige GRIN1 Proteine) receptor, ionotropic, N-methyl D-aspartate 2B (GluN2B) subunit-selective inhibition.

  6. These results highlight the requirement for stringent pharmacogenetic approaches to separate specific on-target effects from nonspecific off-target effects. Importantly, they also demonstrate that the CaMKII (zeige CAMK2G Proteine)/GluN2B interaction is required not only for normal long-term potentiation induction but also for the maintenance of synaptic strength.

  7. GluN2B-dependent calcium signaling and excitatory postsynaptic current, long-term depression, and spatial reversal learning are enhanced in the hippocampus of AC6 (zeige ADCY6 Proteine)(-/-) mice without altering the gross anatomy of the brain

  8. Unpredictable chronic mild stress mice exhibited elevated nucleus accumbens (NAC) shell levels of Glun2B. GluN2b levels were also lower within the NAC core.

  9. These data suggest that chronic early postnatal SSS influences spatial learning and memory ability, levels of hippocampal NR2B, and NR2A (zeige GRIN2A Proteine)/NR2B ratios in adult males.

  10. Results identify crucial determinants in the C-terminal domain of GluN2B subunits in promoting neuronal death in ischemic conditions.

GRIN2B Protein Überblick

Protein Überblick

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.

Alternative names and synonyms associated with GRIN2B

  • glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B)
  • glutamate receptor, ionotropic, N-methyl D-aspartate 2B (Grin2b)
  • glutamate receptor, ionotropic, N-methyl D-aspartate 2B (grin2b)
  • glutamate receptor, ionotropic, NMDA2B (epsilon 2) (Grin2b)
  • AW490526 Protein
  • GluN2B Protein
  • hNR3 Protein
  • MRD6 Protein
  • Nmdar2b Protein
  • nr2b Protein

Bezeichner auf Proteinebene für GRIN2B

NMDA type glutamate receptor , N-methyl D-aspartate receptor subtype 2B , N-methyl-D-aspartate receptor subunit 2B , NMDAR2B , NR2B , glutamate [NMDA] receptor subunit epsilon-2 , glutamate receptor ionotropic, NMDA 2B , N-methyl-D-aspartate receptor subunit 3 , NR3 , glutamate receptor subunit epsilon-2 , glutamate receptor, ionotropic, NMDA2B , N-methyl-D-aspartate receptor subunit NR2B , GluRepsilon2 , N-methyl D-aspartate receptor 2B

GENE ID SPEZIES
751956 Taeniopygia guttata
494009 Canis lupus familiaris
2904 Homo sapiens
24410 Rattus norvegicus
100127347 Xenopus laevis
14812 Mus musculus
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