Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
These preliminary results demonstrated that the GRIN2B gene may confer to some extent the susceptibility to OCD and its symptoms.
Our finding confirms that early-onset EE may be caused not only by gain-of-function variants but also by splice site mutations-in particular those affecting the splice acceptor site of the 10th intron of the GRIN2B gene.
Results indicate that the GRIN2B single nucleotide polymorphisms rs890 might be associated with schizophrenia in the Chinese Han population.
These in vivo changes reflect changes in glutamate transporter (zeige SLC1A1 Proteine) protein (zeige HNRNPU Proteine) in Huntington's disease (HD), mice and human HD post-mortem tissue. Furthermore, NAC was able to rescue (zeige GRIN1 Proteine)changes in key glutamate receptor proteins related to excitotoxicity in HD, including NMDAR2B.
Genetic association of CYP2B6 (zeige CYP2B6 Proteine)*6 and GRIN2B (rs1019385 and rs1806191) single-nucleotide polymorphisms and ketamine-induced EP occurrence.
most rare variants in GluN2A (zeige GRIN2A Proteine) were associated with epilepsy, whereas GluN2B variants were associated with intellectual disability with or without seizures
In this review, mutations in GRIN2B were described as distributed throughout the entire gene in patients with neuropsychiatric and developmental disorders.
Genetic variants were found in GluN2B from patients with neurological or psychiatric disorders resulting in reduced surface expression of GluN2B.
Results found that GluN2B subunit-containing NMDARs were dominant in induced pluripotent stem cell-derived neurons and that tyrosine-protein kinase Fyn (zeige FYN Proteine) potentiated the function of GluN2B subunit-containing NMDARs.
Multiple genetic variants in GRIN2B are jointly associated with gene expression, prefrontal function and behaviour during working memory (WM). These results support the role of GRIN2B genetic variants in WM prefrontal activity in human adults.
Drebrin A (zeige DBN1 Proteine) can be found co-clustering with NR2B-containing NMDARs at the plasma membrane, while NR2A (zeige GRIN2A Proteine)-containing NMDARs co-traffic into the spine cytoplasm but do not co-cluster at the plasma membrane.
Overexpression of EphB2 (zeige EPHB2 Proteine) also rescued the ADDLs-induced depletion of the expression of EphB2 (zeige EPHB2 Proteine) and GluN2B-containing NMDA receptors trafficking in cultured hippocampal neurons.
PGRN (zeige GRN Proteine) decrease, resulting from pathogenic mutations, might compromise the trophism of cortical neurons by affecting GluN2B-contaning NMDA receptors
HumanTau(AT) causes excitotoxicity mediated by NR2B-containing NMDA receptors due to enhanced extracellular glutamate (zeige GRIN1 Proteine).
The NR2B-CREB (zeige CREB1 Proteine)-miR212/132-CRTC1 (zeige CRTC1 Proteine)-CREB (zeige CREB1 Proteine) signal network plays an important role in the regulation of pain.
This study demonstrated that Increasing the GluN2A (zeige GRIN2A Proteine)/GluN2B Ratio in Neurons of the Mouse Basal and Lateral Amygdala Inhibits the Modification of an Existing Fear Memory Trace.
These in vivo changes reflect changes in glutamate transporter (zeige SLC1A1 Proteine) protein (zeige LAPTM4A Proteine) in HD mice and human HD post-mortem tissue. Furthermore, NAC was able to rescue changes in key glutamate (zeige GRIN1 Proteine) receptor proteins related to excitotoxicity in HD, including NMDAR2B.
Data show that hydroxyproline HyP (zeige PHEX Proteine)(10) plays a critical role in maintaining the structural integrity of conantokins conRl-B, which can be correlated with its glutamate (zeige GRIN1 Proteine) receptor, ionotropic, N-methyl D-aspartate 2B (GluN2B) subunit-selective inhibition.
These results highlight the requirement for stringent pharmacogenetic approaches to separate specific on-target effects from nonspecific off-target effects. Importantly, they also demonstrate that the CaMKII (zeige CAMK2G Proteine)/GluN2B interaction is required not only for normal long-term potentiation induction but also for the maintenance of synaptic strength.
GluN2B-dependent calcium signaling and excitatory postsynaptic current, long-term depression, and spatial reversal learning are enhanced in the hippocampus of AC6 (zeige ADCY6 Proteine)(-/-) mice without altering the gross anatomy of the brain
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.
NMDA type glutamate receptor
, N-methyl D-aspartate receptor subtype 2B
, N-methyl-D-aspartate receptor subunit 2B
, glutamate [NMDA] receptor subunit epsilon-2
, glutamate receptor ionotropic, NMDA 2B
, N-methyl-D-aspartate receptor subunit 3
, glutamate receptor subunit epsilon-2
, glutamate receptor, ionotropic, NMDA2B
, N-methyl-D-aspartate receptor subunit NR2B
, N-methyl D-aspartate receptor 2B