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Overexpression of ASL (zeige ADSL ELISA Kits) may be a contributing factor in drug resistance for arginine deprivation therapy.
ASL (zeige ADSL ELISA Kits)-targeting shRNA-induced growth inhibition is associated with decreased cyclin A2 (zeige CCNA2 ELISA Kits) expression and Nitric oxide content in colon cancer.
the mechanism induced by ASL (zeige ADSL ELISA Kits) shRNA which occurred in human breast cancer may be attributed to a decrease in cyclin A2 (zeige CCNA2 ELISA Kits) and NO.
The clinical and biochemical course in variant forms of ASL (zeige ADSL ELISA Kits) deficiency is associated with relevant residual levels of ASL (zeige ADSL ELISA Kits) activity as well as instability of mutant ASL (zeige ADSL ELISA Kits) proteins.
Point mutation of ASS1 (zeige ASS1 ELISA Kits), ASL (zeige ADSL ELISA Kits) and SLC25A13 (zeige slc25a13 ELISA Kits) is associated with citrullinemia (zeige ASS1 ELISA Kits).
Data show that in patients with Argininosuccinate lyase deficiency, the ASl (zeige ADSL ELISA Kits) gene is subject to several mutations, the majority are missense; some more frequent then others.
Our results suggest that ASL (zeige ADSL ELISA Kits) transcripts can contribute to the highly variable phenotype in ASA (zeige ARSA ELISA Kits) patients if expressed at high levels.
Cox (zeige COX8A ELISA Kits) regression analysis showed that ASL (zeige ADSL ELISA Kits) is an independent prognostic marker for HCC (zeige FAM126A ELISA Kits). Therefore, reduced ASL (zeige ADSL ELISA Kits) expression may be a novel maker for poor prognosis in HCC (zeige FAM126A ELISA Kits) patients
analysis of mutant argininosuccinate lyase in argininosuccinic aciduria
extent of protection of ASL (zeige ADSL ELISA Kits) and delta-crystallin at different ratios of alphaA-crystallin (zeige CRYAA ELISA Kits)
Enterocyte-derived ASL (zeige ADSL ELISA Kits) has a protective role in necrotizing enterocolitis.
This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described.
, delta crystallin II
, delta-2 crystallin