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These results showed that BLM enters the nucleus via the importin beta1, RanGDP and NTF2 dependent pathway, demonstrating for the first time the nuclear trafficking mechanism of a DNA helicase.
RAN Translation Regulated by Muscleblind Proteins in Myotonic Dystrophy Type 2
we demonstrated that DICER (zeige DICER1 ELISA Kits) (rs3742330) and RAN (rs14035) were associated with the survival of HCC (zeige FAM126A ELISA Kits) patients
RAN translation from antisense CCG repeats generates novel proteins that accumulate in ubiquitinated inclusions in Fragile X-associated tremor/ataxia syndrome patients.
Binding of Ran to NTF2 (zeige NUTF2 ELISA Kits) is required for NTF2 (zeige NUTF2 ELISA Kits) to inhibit nuclear expansion and import of large cargo molecules.
FGF2 (zeige FGF2 ELISA Kits) nuclear translocation is regulated by Karyopherin-beta2 and Ran GTPase in human glioblastoma cells
Enterovirus 71-induced downregulation of miR (zeige MLXIP ELISA Kits)-197 expression increased the expression of RAN, which supported the nuclear transport of the essential viral proteins 3D/3CD and host protein hnRNP K (zeige HNRNPK ELISA Kits) for viral replication.
Inter-cellular transport of ran GTPase
Data show that RNA-binding protein (zeige PTBP1 ELISA Kits) LIN28B (zeige LIN28B ELISA Kits) coordinates the expression of the oncogene (zeige RAB1A ELISA Kits) RAN protein and aurora A kinase (AURKA (zeige AURKA ELISA Kits)) in neuroblastoma (zeige ARHGEF16 ELISA Kits).
Elevated metaphase RanGTP levels use Ubr5 (zeige UBR5 ELISA Kits) to couple overall chromosome congression to SAC (zeige ADCY10 ELISA Kits) silencing.
Data suggest Ran activation by RanBP1 (zeige RANBP1 ELISA Kits) in macrophages promotes Legionella phagosome formation and phagocytosis; LegG1 functions as bacterial Ran activator, localizes to phagosomes, and promotes microtubule stabilization, phagocytosis, and replication.
Augmented expression of Ran in progranulin (zeige GRN ELISA Kits)-deficient neurons restores nuclear TDP-43 (zeige TARDBP ELISA Kits) levels and improves their survival.
Reduction in Ran levels causes cytoplasmic decrease and nuclear accumulation of importin alpha leading to cellular senescence in normal cells.
a novel connection between the hyper-activation of the small GTPase Ran and the matricellular protein SMOC-2 (zeige SMOC2 ELISA Kits) that has important consequences for oncogenic transformation.
A critical function of RanBP2 (zeige RANBP2 ELISA Kits) is to capture recycling RanGTP-importin-beta (zeige KPNB1 ELISA Kits) complexes at cytoplasmic fibrils to allow for adequate classical nuclear localization signal-mediated cargo import.
Downregulation of the Ran GTPase effector RanBP1 (zeige RANBP1 ELISA Kits) is required for nuclear reorganisation.
Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation.
intracellular Ran protein levels control the nuclear retention for selective transcription factors such as c-Jun (zeige JUN ELISA Kits) and c-Fos of AP-1 (zeige JUN ELISA Kits), which is known to be critical in T cell activation and proliferation and lymphokine (zeige IL2 ELISA Kits) secretion.
expression of Ran/M1 (zeige TLR4 ELISA Kits) and Ran/M2 increased in pachytene spermatocytes with progressive transcript accumulation until they reached the round spermatid stage, in the seminiferous epithelium of adults
RanGDP is regulated by phosphorylation and regulated by NTF2 (zeige NUTF2 ELISA Kits)
the Canoe Ras-association (RA) domains directly bind RanGTP
Knockdown of the small G protein Ran, which is essential for nuclear transport, leads to an arrest of EcR in the cytoplasm, but does not prevent efficient nuclear import of the most important heterodimerization partner of EcR, ultraspiracle (Usp).
results demonstrate that distinctly from its role in spindle assembly, RanGTP maintains spindle microtubules in anaphase through the local activation of ISWI and that this is essential for proper chromosome segregation
gtpase ran localizes around the microtubule spindle in vivo during mitosis in Drosophila embryos
anillin (zeige ANLN ELISA Kits) and Peanut are involved in pseudocleavage furrow ingression in syncytial embryos, a process that is regulated by Ran
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
GTP-binding nuclear protein Ran
, GTPase Ran
, androgen receptor-associated protein 24
, guanosine triphosphatase Ran
, member RAS oncogene family
, ras-like protein TC4
, ras-related nuclear protein
, RAN, member RAS oncogene family
, RAN, member RAS oncogene family pseudogene 1
, GTP-binding nuclear protein Ran, testis-specific isoform
, RAS-like, family 2, locus 9, pseudogene
, Ran GTPase