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In a family study of a patient with chronic granulomatous disease, the mutation in the CYBB (zeige CYBB ELISA Kits) gene was confirmed to be pathogenic, and the three variants in the CYBA gene were benign.
We demonstrated that rapid deletion of p22phox is possible and that the activity of Nox1 (zeige NOX1 ELISA Kits) and Nox4 (zeige NOX4 ELISA Kits) but not Nox5 (zeige NOX5 ELISA Kits) exclusively depends on p22phox.
NOX5 (zeige NOX5 ELISA Kits)-p22phox complex drives monocytic differentiation into dendritic cells, and thus could be critical for immunity and inflammation.
PI3K (zeige PIK3CA ELISA Kits)/AKT (zeige AKT1 ELISA Kits) signaling only occurs when FLT3 (zeige FLT3 ELISA Kits)-ITD is expressed at the plasma membrane and is required for the production of NOX-generated ROS (zeige ROS1 ELISA Kits). ER retention of FLT3 (zeige FLT3 ELISA Kits)-ITD resulted in NOX4 (zeige NOX4 ELISA Kits) deglycosylation and p22(phox) protein degradation.
CYBA gene ()49A>G polymorphism modifies the risk of coronary artery disease
The study demonstrated that the genetic variants of rs9932581 and rs1049255 in CYBA might not be associated with preeclampsia.
p22phox C242T polymorphism has a possible role in changing the genetic susceptibility to late-onset AD in ApoE 4 carriers of northern Han Chinese origin.
CYBA mutations lead to one of the autosomal recessive forms of chronic granulomatous disease (AR220CGD) clinically characterized by recurrent and severe infections in early chilA large number of genetic variations of CYBA have been reported, among them the C242T polymorphism, which has been extensively studied in association with coronary artery and heart diseases, but conflicting results continue to be reported. [Review]
C242T single-nucleotide polymorphism causes p22(phox) structural changes that inhibit endothelial Nox2 (zeige CYBB ELISA Kits) activation and oxidative response to tumor necrosis factor-alpha (zeige TNF ELISA Kits) or high-glucose stimulation. C242T single-nucleotide polymorphism may represent a natural protective mechanism against inflammatory cardiovascular diseases.
CYBA C242T correlates with microalbuminuria onset in the French DT1 cohort.
Identification of a PPAR-gamma (zeige PPARG ELISA Kits) --> NF-kappaB (zeige NFKB1 ELISA Kits) --> p22phox neuroprotective signaling cascade opens a new avenue for protecting the brain against ischemic insult.
Knockout of the cytochrome P450 reductase by CRISPR/Cas9 technology (POR(-/-)) in HEK293 cells overexpressing Nox4 or Nox5 did not interfere with ROS production in intact cells. However, POR(-/-) abolished the signal in NADPH-stimulated assays using membrane fractions from the very same cells. Moreover, membranes of rat smooth muscle cells treated with angiotensin II showed an increased NADPH-dependent signal with lucigen
p22phox mRNA expression was increased in diet-induced obese (DIO) mice.
The present study provides evidence that augmented EGFRtk impairs vascular function by NADPH oxidase (zeige NOX1 ELISA Kits)-dependent mechanism. Therefore, EGFRtk and oxidative stress should be potential targets to treat vascular dysfunction in TD2.
Vascular hnRNP-C expression is regulated by ROS (zeige ROS1 ELISA Kits) derived from NADPH (zeige FDXR ELISA Kits) oxidases and that the effects of NADPH oxidase (zeige NOX1 ELISA Kits) on vascular activation are mediated in part by protein kinase (zeige CDK7 ELISA Kits) CK1alpha (zeige CSNK1A1 ELISA Kits).
Enhanced p22(phox) expression causes vascular dysfunction through ERK1/2 (zeige MAPK1/3 ELISA Kits) and p38-mitogen-activated protein kinase (zeige MAPK14 ELISA Kits)-dependent mechanisms in male type 2 diabetic mice.
The first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 (zeige NOXO1 ELISA Kits) and NOXA1 (zeige NOXA1 ELISA Kits) and membrane-bound p22(phox), is presented.
renal expression of Nox-2 (zeige CYBB ELISA Kits), p22(phox), and p47(phox), components of NADPH oxidase (zeige NOX1 ELISA Kits), are upregulated in GSD-Ia mice compared with controls
cytochrome b558 expression is downregulated via the reduction of heme availability after NADPH oxidase (zeige NOX1 ELISA Kits) is inhibited by HO-1 (zeige HMOX1 ELISA Kits)
LPS (zeige TLR4 ELISA Kits) treatment enhanced protein levels of p22(phox), a catalytic subunit of NADPH oxidase (zeige NOX1 ELISA Kits), and increased NADPH oxidase (zeige NOX1 ELISA Kits) activity and levels of superoxide radicals and hydrogen peroxide.
Upregulation of PPAR-gamma and NADPH oxidases are involved in restenosis.
CRP (zeige CRP ELISA Kits) inhibits endothelium-dependent NO-mediated dilation in coronary arterioles by producing superoxide from NAD(P)H (zeige NQO1 ELISA Kits) oxidase via p38 (zeige MAPK14 ELISA Kits) kinase activation
Reactive oxygen species generated by NADPH oxidase (zeige NOX1 ELISA Kits) contribute to the aberrant pulmonary arterial responses in piglets exposed to 3 days of hypoxia.
Angiotensin II inhibits the Na+/K+ pump via protein kinase c epsilon (zeige PRKCE ELISA Kits)-dependent activation of NADPH oxidase (zeige NOX1 ELISA Kits) subunits.
Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.
, cytochrome b-245, alpha polypeptide
, predicted cytochrome b-245, alpha polypeptide
, Cytochrome b(558) alpha chain
, Cytochrome b558 subunit alpha
, Neutrophil cytochrome b 22 kDa polypeptide
, Superoxide-generating NADPH oxidase light chain subunit
, cytochrome b-245 light chain
, flavocytochrome b558 (p22phox)
, p22 phagocyte B-cytochrome
, cytochrome b light chain
, cytochrome b(558) alpha chain
, cytochrome b(558) alpha-subunit
, cytochrome b, alpha polypeptide
, cytochrome b558 subunit alpha
, flavocytochrome b-558 alpha polypeptide
, neutrophil cytochrome b 22 kDa polypeptide
, superoxide-generating NADPH oxidase light chain subunit
, cytochrome beta-558
, p22 phox
, cytochrome b558 alpha-subunit
, NADPH oxidase light chain subunit