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SMYD1 serves as an Serum Response Factor-interacting protein, enhances Serum Response Factor DNA binding activity, and is required for endothelial cell migration and tube formation to regulate angiogenesis.
SMYD1 and G6PD (zeige G6PD Proteine) modulation are critical events for miR (zeige MLXIP Proteine)-206-mediated differentiation of rhabdomyosarcoma.
HDGF (zeige HDGF Proteine) functions as a transcriptional repressor of the SMYD1 gene through interaction with the transcriptional corepressor CtBP (zeige CTBP2 Proteine).
Smyd1 is responsible for restricting growth in the adult heart, with its absence leading to cellular hypertrophy, organ remodeling, and fulminate heart failure. Molecular studies reveal Smyd1 to be a muscle-specific (zeige EIF3K Proteine) regulator of gene expression and indicate that Smyd1 modulates expression of gene isoforms whose expression is associated with cardiac pathology. Activation of Smyd1 can prevent pathological cell growth.
This work illustrates a crucial role for SMYD1 in skeletal muscle physiology and myofibril integrity.
Deletion of Smyd1 impaired myoblast differentiation, resulted in fewer myofibers and decreased expression of muscle-specific (zeige EIF3K Proteine) genes
Smyd1 is required for maintaining cardiomyocyte proliferation at minimally two different embryonic heart developmental stages
suggest for the first time that, in addition to being a master redox regulator of protein disulfide bonds and nitrosation, Trx1 (zeige TXN Proteine) may also modulate lysine methylation, a non-redox post-translational modification, via the regulation of SMYD1 expression
the skNAC (zeige NACa1 Proteine)-Smyd1 complex is involved in transcriptional regulation both via the control of histone methylation and histone (de)acetylation.
skNAC (zeige NACa1 Proteine) binds to the E3 SUMO ligase mammalian Mms21/Nse2 (zeige NSMCE2 Proteine) and that knockdown of Nse2 (zeige NSMCE2 Proteine) expression inhibits specific aspects of myogenic differentiation, accompanied by a partial blockade of the nuclear-to-cytoplasmic translocation of the skNAC (zeige NACa1 Proteine)-Smyd1 complex
MYND domain may primarily serve as a protein interaction module and cooperate SmyD1 with skNAC (zeige NACa1 Proteine) to regulate cardiomyocyte growth and maturation.
The muscle-specific (zeige EIF3K Proteine) transcription factor skNAC (zeige NACa1 Proteine) is the major binding partner for Smyd1 in the developing heart.
Bop (zeige OPN1SW Proteine) encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis.
Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.
CD8 beta opposite
, SET and MYND domain-containing protein 1
, histone-lysine N-methyltransferase SMYD1
, zinc finger, MYND domain containing 18
, CD8beta opposite strand
, histone-lysine N-methyltransferase Smyd1
, zinc finger protein BOP
, SET and MYND domain containing 1
, SET and MYND domain-containing 1
, SET and MYND domain containing protein
, SET and zf-MYND domain-containing protein
, SET and MYND domain-containing protein 1-like