Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Select your species
inactivation of both exosc9, which encodes a component of the RNA exosome, and ptbp1, which encodes an RNA-binding protein abundant in Xenopus embryonic skin, impairs embryonic Xenopus skin development.
Polypyrimidine tract binding protein prevents activity of an intronic regulatory element that promotes usage of a composite 3'-terminal exon
PTBP1 is a novel regulator of MCL1 (zeige MCL1 ELISA Kits) mRNA by which it controls apoptotic response to antitubulin chemotherapeutics.
PTB interacts specifically with 3'UTR (zeige UTS2R ELISA Kits) of p53 (zeige TP53 ELISA Kits) mRNA and positively regulates expression of p53 (zeige TP53 ELISA Kits) isoforms. PTB showed some overlapping binding regions in the p53 (zeige TP53 ELISA Kits) 3'UTR (zeige UTS2R ELISA Kits) with miR (zeige MLXIP ELISA Kits)-1285. Knockdown of miR (zeige MLXIP ELISA Kits)-1285 as well as expression of p53 (zeige TP53 ELISA Kits) 3'UTR (zeige UTS2R ELISA Kits) with mutated miR (zeige MLXIP ELISA Kits)-1285 binding sites resulted in enhanced association of PTB with the 3'UTR (zeige UTS2R ELISA Kits), which provides mechanistic insights of this interplay.
It has been established that PTBP1 and PTBP2 (zeige PTBP2 ELISA Kits) are members of a family of cryptic exon repressors.
These results demonstrate that during early stages of splicing, exon RNP (zeige RNPC3 ELISA Kits) complexes are highly dynamic with many proteins failing to bind during PTBP1 arrest.
Studied interactions of polypyrimidine tract-binding protein (PTBP1), pyruvate kinase M2 (PKM2), and STAT3 (signal transducer and activator of transcription 3 (zeige STAT3 ELISA Kits)) in oncogenesis of anaplastic large cell lymphoma (ALCL). Results show that in ALCL cells, PTBP1 is crucial for PKM2 phosphorylation of STAT3 (zeige STAT3 ELISA Kits) in the nucleus.
Expression of ATG10 negatively regulated by PTBP1 and is associated with metastasis of colorectal cancer cells.
Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm.
follow-up molecular analyses of one splicing factor (zeige SLU7 ELISA Kits) PTBP1 revealed its impact on disease-associated splicing patterns in Huntington's disease (HD). Collectively, our data provide genomic evidence for widespread splicing dysregulation in HD brains, and suggest the role of aberrant alternative splicing in the pathogenesis of HD
CD5 (zeige CD5 ELISA Kits) transcription is increased, leading to the production of three mRNA isoforms by APA (zeige ENPEP ELISA Kits), all contributing for protein production, at different levels. PTBP1 binds in the vicinity of pA1 (zeige PAGR1 ELISA Kits), leading to an increase in mRNA levels and miR (zeige MLXIP ELISA Kits)-204 targets the longer CD5 (zeige CD5 ELISA Kits) mRNA.
Increased expression of microRNA miR (zeige MLXIP ELISA Kits)-145 combined with knockdown of PTBP1 protein contributed to the greater and longer growth suppression compared with each single treatment.
This knockin Ptbp1 rescued a forebrain-specific, but not a pan-neuronal, Ptbp2 (zeige PTBP2 ELISA Kits) knockout, demonstrating both redundant and distinct roles for the proteins. Many developmentally regulated exons exhibited different sensitivities to PTBP1 and PTBP2 (zeige PTBP2 ELISA Kits).
Results indicate that heterogeneous nuclear ribonucleoprotein I (hnRNPI) plays a critical role in establishing neonatal immune adaptation and preventing colitis and colorectal cancer.
Thus, PTBP1 controls the activity of Pbx1 (zeige PBX1 ELISA Kits) to suppress its neuronal transcriptional program prior to induction of neuronal progenitor cells development.
showed polypyrimidine tract binding protein (PTBP)-dependent alternative splicing of CaMKIIalpha (zeige CAMK2 ELISA Kits) transcripts in the lens
This may account for the tight correlation between Hps1 with Ptbp1 expression levels observed across mammalian tissues.
The expression levels of three splicing factors, ESRP1 (zeige ESRP1 ELISA Kits), PTB and SF2/ASF (zeige SRSF1 ELISA Kits), are significantly altered during cardiac hypertrophy in mice.
Study reports that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR (zeige MLXIP ELISA Kits)-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons.
The polypyrimidine tract binding proteins PTBP1 and PTBP2 (zeige PTBP2 ELISA Kits) repressed Psd-95 (zeige DLG4 ELISA Kits) (also known as Dlg4 (zeige DLG4 ELISA Kits)) exon 18 splicing, leading to premature translation termination and nonsense-mediated mRNA decay.
PTBP1 is not required for the earliest isovolumetric divisions and differentiation steps of the zygote up to the formation of the blastocyst.
RBM4 (zeige RBM4 ELISA Kits) may synergize its effect on muscle cell-specific alternative splicing by down-regulating PTB expression and antagonizing the activity of PTB in exon selection
Data report on a zebrafish maternal-effect (zeige NLRP5 ELISA Kits) mutant, brom bones, which is defective in the cytosolic Ca(2 (zeige CA2 ELISA Kits)+) rise and subsequent egg activation events, including cortical granule exocytosis and cytoplasmic segregation [brom bones].
Two stretches of polypyrimidine tracts designated PPT1 and PPT2 which influence the IRES activity of cx55.5 protein were identified; deletion of PPT1 results in an appreciable decrease of the IRES activity
PTB1 is a splicing factor (zeige SLU7 ELISA Kits) that influences alternative splicing and acts at the polypyrimidine tract.
Alternative splicing (AS) patterns as well as the expression of key flowering regulators were massively changed in a PTB1/2 level-dependent manner.
AtPTB1 and AtPTB2 are widely expressed in almost all tissues, with the highest expression levels in late-maturing and mature pollen grains, and are crucial for pollen germination. [AtPTB1]
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
polypyrimidine tract binding protein 1
, hnrnp I
, hnRNP I-related RNA transport protein VgRBP60
, polypyrimidine tract-binding protein
, polypyrimidine tract-binding protein 1
, 57 kDa RNA-binding protein PPTB-1
, RNA-binding protein
, heterogeneous nuclear ribonucleoprotein I
, heterogeneous nuclear ribonucleoprotein polypeptide I
, hnRNP I
, polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I)
, pyrimidine binding protein 1
, pyrimidine binding protein 2
, brom bones