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BLIMP1 (PRDM1)expression begins throughout the hypoblast at stage 1 and emerges in single primordial germ cell (PGC (zeige PGC ELISA Kits)) precursors in the posterior epiblast at stage 2.
The timing of shade expression is determined by its transcriptional activator betaFtz-f1. The betaftz-f1 gene is activated after a decline in the expression of its transcriptional repressor Blimp-1.
Blimp-1 gene is transcribed during prepupal development when the ecdysteroid titer is high, but the expressed mRNA degrades rapidly.
Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo.
These results suggest that the transient transcriptional repressor dBlimp-1 is important for determining developmental timing in the ecdysone-induced pathway.
Expression of the M- and N-cadherins, previously implicated in driving adaxial cell migration, is largely unaffected by loss of Prdm1a function, suggesting that differential cadherin expression is not sufficient for adaxial cell migration
Prdm1a functions as both a transcriptional activator and repressor during neural crest development.
identify sox6 cis (zeige CISH ELISA Kits)-regulatory sequences that drive fast-twitch-specific expression in a Prdm1a-dependent manner
prdm1a expression is upregulated in the absence of Notch (zeige NOTCH1 ELISA Kits) function, and inhibiting Notch (zeige NOTCH1 ELISA Kits) signaling fails to rescue prdm1a mutants
prdm1a Regulates sox10 (zeige SOX10 ELISA Kits) and islet1 (zeige ISL1 ELISA Kits) in the development of neural crest and Rohon-Beard sensory neurons.
These results indicate an essential role for prdm1a in the development of the zebrafish craniofacial skeleton.
Here we show that the gene u-boot (ubo), a mutation in which disrupts the induction of embryonic slow-twitch fibers, encodes the zebrafish homolog of Blimp-1
The transcriptional regulator Blimp-1 plays a role in the inception of Neural Crest progenitor fate through BMP signalling.
prdm1/blimp1 has roles in embryo patterning and organogenesis
prdm1 functions to promote the cell fate specification of both neural crest cells and sensory neurons
Blimp-1 binds to the promoters of PD-1 (zeige PDCD1 ELISA Kits) and TIGIT (zeige TIGIT ELISA Kits) and positively regulates their expression in patients with acute myeloid leukemia (zeige BCL11A ELISA Kits).
the promoter hypermethylation of PRDM1 harbored a predominant role in the downregulation of PRDM1 expression, significantly affecting the biological behavior of tumor cells in EN-NK/T-NT.
Blimp-1 suppresses the transcription of CUL4A (zeige CUL4A ELISA Kits), resulting in the maintenance of the expression of Aiolos (zeige IKZF3 ELISA Kits) and Ikaros (zeige IKZF1 ELISA Kits).
HSP70 (zeige HSP70 ELISA Kits)-Hrd1 (zeige SYVN1 ELISA Kits) axis represents a potential therapeutic target for restoring the oncorepressor activity of unstable lymphoma-associated Blimp-1 mutants.
SOX2 (zeige SOX2 ELISA Kits) repression in TCam-2 cells can be abrogated by recruitment of the constitutively expressed H3K27 demethylase (zeige MBD2 ELISA Kits) UTX (zeige KDM6A ELISA Kits) to the SOX2 (zeige SOX2 ELISA Kits) promoter through retinoid signaling, leading to expression of neuronal and other lineage genes. SOX17 (zeige SOX17 ELISA Kits) has been shown to initiate human PGC (zeige PGC ELISA Kits) specification, with its target PRDM1 suppressing mesendodermal genes
The interaction between c-Maf (zeige MAF ELISA Kits) and RORgammat, and Blimp-1.
these results provide novel clinical and biological insight into the tumor-suppressive role of PRDM1/BLIMP-1 in ABC (zeige ABCB6 ELISA Kits)-DLBCL patients and suggest that loss of PRDM1/BLIMP-1 function contributes to the overall poor prognosis of ABC (zeige ABCB6 ELISA Kits)-DLBCL patients.
PRDM1 was identified as a susceptibility gene for systemic sclerosis.
Data indicate that BTG2 (zeige BTG2 ELISA Kits), MAP3K11 (zeige MAP3K11 ELISA Kits), RPS6KA1 (zeige RPS6KA1 ELISA Kits) and PRDM1 as putative targets of microRNA miR (zeige MLXIP ELISA Kits)-125b.
we identified MIR155HG and TERC to be transcriptionally downregulated by PRDM1 in two PRDM1-null NK-cell lines when it is ectopically expressed. These findings suggest that ZFAS1 and other dysregulated long non-coding RNAs may be involved in natural killer/T-cell lymphoma pathobiology through regulation of cancer-related genes, and loss-of-PRDM1 expression in natural killer/T-cell lymphomas tumorigenesis
Posterior PRDM1 contributes more broadly to the developing fetal-maternal connection than previously recognized, and PRDM1 and STELLA (zeige DPPA3 ELISA Kits), while overlapping in putative primordial germ cells, also co-localize in several other tissues
Blimp1 deficiency resulted in reduced suppressive ability of Tfr (zeige TFRC ELISA Kits) cells. This study identifies that Tfr (zeige TFRC ELISA Kits) cells are potent suppressors of immunity and are controlled by Blimp1.
Data show that TLR4 (zeige TLR4 ELISA Kits)-mediated up-regulation of Blimp-1 led to the down-regulation of NLRP12 expression in dextran sulfate sodium (DSS (zeige PMP22 ELISA Kits))-induced colitis.
Results established a molecular mechanism of TNF-a (zeige TNF ELISA Kits)-induced osteoclasts differentiation, and provided insights into the potential contribution of Blimp1 in the regulation of osteoclastogenesis by TNF-a (zeige TNF ELISA Kits).
results show that the intersection of three or more transcription factors is required to correctly regulate the spatial and temporal features of Blimp1 enhancer expression
findings show that Prdm1 acts independently of Aire (zeige AIRE ELISA Kits), a crucial transcription factor implicated in medullary thymic epithelial cells function; data highlight a previously unrecognized role for Prdm1 in regulating thymic epithelial function
Prdm1 repressed expression of the gene encoding cathepsin S (Ctss (zeige CTSS ELISA Kits)). Prdm1 deficiency in dendritic cells led to loss of appropriate regulation of Ctss (zeige CTSS ELISA Kits) expression in female mice and thereby modulated antigen presentation and the follicular helper T cell repertoire to contribute to autoimmunity in lupus.
Blimp1 is required to maintain a highly proliferative luminal subset necessary for mammary gland development and homeostasis.
Attenuated leptin-receptor (LEPR (zeige LEPR ELISA Kits)) expression is essential for the development and maintenance of acute lymphoblastic leukemia (ALL), and that fasting inhibits ALL development by upregulation of LEPR (zeige LEPR ELISA Kits) and its downstream signaling through the protein PR/SET domain 1 (PRDM1).
role of Blimp-1 as a critical regulator of CD4 (zeige CD4 ELISA Kits) dysfunction and links it to the CD8 (zeige CD8A ELISA Kits) T cell dysfunctionality observed in infected mice.
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.
PR domain containing 1, with ZNF domain
, Blimp-1 protein
, B lymphocyte-induced maturation protein 1
, PR domain zinc finger protein 1
, PR domain-containing 1
, U boot
, B lymphocyte induced maturation protein 1
, PR domain zinc finger protein 1-like
, B-lymphocyte-induced maturation protein 1
, PRDI-binding factor-1
, beta-interferon gene positive-regulatory domain I binding factor
, B lymphocyte induced maturation protein
, PR domain containing 1 with ZNF domain
, PR domain-containing protein 1
, beta-interferon gene positive regulatory domain I-binding factor