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Human Polyclonal HDAC9 Primary Antibody für IF, IHC (p) - ABIN387960
Petrie, Guidez, Howell, Healy, Waxman, Greaves, Zelent: The histone deacetylase 9 gene encodes multiple protein isoforms. in The Journal of biological chemistry 2003
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Human Polyclonal HDAC9 Primary Antibody für WB - ABIN223304
Maltepe, Krampitz, Okazaki, Red-Horse, Mak, Simon, Fisher: Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. in Development (Cambridge, England) 2005
Show all 3 Pubmed References
Guinea Pig Polyclonal HDAC9 Primary Antibody für ChIP, IHC - ABIN2775576
Han, He, Wu, Liu, Chen: Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2. in Journal of molecular biology 2004
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Human Polyclonal HDAC9 Primary Antibody für IHC (p), WB - ABIN387961
David, Cardoso, Marques, Marques, Silva, Santos, Boavida: Molecular characterization of a familial translocation implicates disruption of HDAC9 and possible position effect on TGFbeta2 in the pathogenesis of Peters' anomaly. in Genomics 2003
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Cow (Bovine) Polyclonal HDAC9 Primary Antibody für WB - ABIN2775579
Su, Becker, Kozyrskyj, Hayglass: Epigenetic regulation of established human type 1 versus type 2 cytokine responses. in The Journal of allergy and clinical immunology 2008
post-translational modification of Nkx3.2 (zeige NKX3-2 Antikörper) employing HDAC9-PIASy (zeige PIAS4 Antikörper)-RNF4 (zeige RNF4 Antikörper) axis plays a crucial role in controlling chondrocyte viability and hypertrophic maturation during skeletal development in vertebrates.
Data show that the gene encoding the transcription factor SOX9 (zeige SOX9 Antikörper) was identified by a global transcriptomic approach as an HDAC9 target gene.
The minor allele A of SNP rs2107595 increased coronary artery disease risk and the severity of coronary atherosclerosis in a Chinese Han population.
in leiomyosarcomas (LMS), this two-faced trait of MEF2 (zeige MEF2A Antikörper) is relevant for tumor aggressiveness. Class IIa HDACs are overexpressed in 22% of LMS, where high levels of MEF2 (zeige MEF2A Antikörper), HDAC4 (zeige HDAC4 Antikörper) and HDAC9 inversely correlate with overall survival. The knock out of HDAC9 suppresses the transformed phenotype of LMS cells, by restoring the transcriptional proficiency of some MEF2 (zeige MEF2A Antikörper)-target loci
Based on this study, it is suggested that HDAC9 regulates the formation of APBs and could be a candidate for the target of ALT-cancer therapy.
PC3/Tis21 (zeige BTG2 Antikörper) associates with HDAC1 (zeige HDAC1 Antikörper), HDAC4 (zeige HDAC4 Antikörper), and HDAC9 in vivo, in fibroblast cells.
HDAC9 is a target of miR (zeige MLXIP Antikörper)-377 in oral squamous cell carcinoma.
Studied HDAC9 gene's association with an increased susceptibility to acute coronary syndrome (ACS) in Chinese Han population. The results revealed a significant association of rs2240419 with ACS risk in which the A allele (P = 0.047) and the A allele carriers (AA + AG) (P = 0.037) were more likely to be in ACS group as compared to those in the control group.
Downregulation of HDAC9 promotes gliomas.
overexpression of HDAC9 contributes to OSCC carcinogenesis via targeting a transcription factor, MEF2D (zeige MEF2D Antikörper), and NR4A1/Nur77 (zeige NR4A1 Antikörper), a pro-apoptotic MEF2 (zeige MEF2A Antikörper) target
Xenograft study in nude mice showed that downregulation of HDAC9 inhibited tumor growth and development in vivo.
Dach2 (zeige DACH2 Antikörper) and Hdac9 mediate the effects of muscle activity on muscle reinnervation; Myog (zeige MYOG Antikörper) and Gdf5 (zeige GDF5 Antikörper) appear to stimulate muscle reinnervation through parallel pathways
HDAC9 is a novel, important and physiologically relevant modulator of bone remodeling and skeletal homeostasis.
Class IIa HDAC9 interact with Class IIb HDAC6 to modulate cell movement and survival in GnRH neurons
Compared with HDAC9(+/+)ApoE (zeige APOE Antikörper)(-/-) mice, HDAC9(-/-)ApoE (zeige APOE Antikörper)(-/-) mice exhibited markedly reduced lesion sizes throughout atherosclerotic aortas and significantly less advanced lesions.
HDAC9 deletion decreased atherosclerosis in LDLr (zeige LDLR Antikörper)(-/-) mice with minimal effect on plasma lipids. Macrophage HDAC9 upregulation is atherogenic via suppression of cholesterol efflux and generation of alternatively activated macrophages in atherosclerosis.
Genetic ablation of HDAC9 improves adipogenic differentiation and systemic metabolic state during a high-fat diet, resulting in diminished weight gain, improved glucose tolerance and insulin (zeige INS Antikörper) sensitivity, and reduced hepatosteatosis.
Dephosphorylation at a conserved SP motif governs cAMP sensitivity and nuclear localization of class IIa histone deacetylases HDAC4 (zeige HDAC5 Antikörper), 5 and 9
HDAC9 promotes angiogenesis and transcriptionally represses the endothelial cell miR-17-92 cluster.
HDAC9 is responsible for repressing ChAT gene expression in NG108-15 neuronal cells and thus plays an important role in cholinergic differentiation.
HDA9 might be a novel chromatin protein that negatively regulates plant sensitivity to salt and drought stresses.
HDA9 prevents precocious flowering under SD conditions by curbing the hyperactivation of AGL19, an upstream activator of FT, through resetting the local chromatin environment.
HDA9 negatively influences germination and is involved in the suppression of seedling traits in dry seeds, probably by transcriptional repression via histone deacetylation.
The data indicate thatHDA9 represses flowering by repressing AGL19 gene expressionindependently of CONSTANS or FLC pathways.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.
MEF-2 interacting transcription repressor (MITR) protein
, histone deacetylase 4/5-related protein
, histone deacetylase 7B
, MEF2-interacting transcription repressor MITR
, histone deacetylase-related protein
, histone deacetylase 9
, histone deacetylase 9-B
, histone deacetylase 9, MITR protein
, LOW QUALITY PROTEIN: histone deacetylase 9