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Study found increased HDAC7 expression in human pancreatic islets from type 2 diabetic compared with non-diabetic donors. HDAC7 expression correlated negatively with insulin (zeige INS ELISA Kits) secretion in human islets.
silencing HDAC7 can reset the tumor suppressor activity of STAT3 (zeige STAT3 ELISA Kits), independently of the EGFR (zeige EGFR ELISA Kits)/PTEN/TP53 (zeige TP53 ELISA Kits) background of the glioblastoma.
This study demonstrated a simple and straightforward method of quantifying proneural/mesenchymal markers in glioblastoma. Of note, HDAC7 expression might be a novel therapeutic target in glioblastoma treatment.
identify a new target of ROCK signaling via myosin phosphatase subunit (MYPT1 (zeige PPP1R12A ELISA Kits)) and histone deacetylase (zeige HDAC1 ELISA Kits) (HDAC7) at the nuclear level
Study identifies the miR (zeige MLXIP ELISA Kits)-34a-HDAC1 (zeige HDAC1 ELISA Kits)/HDAC7-HSP70 (zeige HSP70 ELISA Kits) K246 axis as a novel molecular signature predictive of therapy resistance.
The transcriptional function of HCS (zeige HLCS ELISA Kits) was shown by in vitro pull down and in vivo co-immunoprecipitation assays to depend on its interaction with the histone deacetylases HDAC1 (zeige HDAC1 ELISA Kits), HDAC2 (zeige HDAC2 ELISA Kits) and HDAC7
endothelial progenitor cells involved in the angiogenesis might be controlled by VEGF (zeige VEGFA ELISA Kits)-PKD1 (zeige PKD1 ELISA Kits)-HDAC7 axis, which regulates the EPCs angiogenesis by PKD1 (zeige PKD1 ELISA Kits), but not the ERK (zeige EPHB2 ELISA Kits) and PI3K (zeige PIK3CA ELISA Kits) pathway
Histone deacetylase 7 promotes Toll-like receptor 4 (zeige TLR4 ELISA Kits)-dependent proinflammatory gene expression in macrophages.
Expression of JHDM2A (zeige KDM3A ELISA Kits) was significantly increased but HDAC2 (zeige HDAC2 ELISA Kits), HDAC7, and SUV39H2 (zeige SUV39H2 ELISA Kits) were significantly down-regulated in Systemic Sclerosis B cells relative to controls
Authors identified acetyltransferase p300 (zeige EP300 ELISA Kits) and deacetylase HDAC7 as enzymes modulating human T cell leukemia virus type 1 Tax (zeige CNTN2 ELISA Kits) protein acetylation.
HDAC7 is a bona fide transcriptional repressor essential for B cell development.
In the dorsal hippocampus, HDAC7 expression is decreased following contextual fear conditioning.
This study demonstrated that hdac7 decrease in skeletal muscle in muscle atrophy.
HDAC7 in osteoclasts is an important molecular regulator of MITF (zeige MITF ELISA Kits) activity and bone homeostasis.
Hdac7 degradation enhances beta-catenin (zeige CTNNB1 ELISA Kits) transcriptional activity in growth plate chondrocytes.
In hepatic stellate cells, CYLD (zeige CYLD ELISA Kits) removed HDAC7 from the hepatocyte growth factor (zeige HGF ELISA Kits) promoter and induced HGF (zeige HGF ELISA Kits) expression.
HDAC7 overexpression suppresses, whereas HDAC7 deletion enhances, osteoclastogenesis
Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance
Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear beta-catenin (zeige CTNNB1 ELISA Kits) translocation.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, histone deacetylase 7A
, histone deacetylase 7