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Data, including data from studies using transgenic mice, suggest that oligodendroglial myelination requires astrocyte-derived lipids; oligodendrocyte-specific inactivation of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP), an essential factor in lipid biosynthesis along with SREBP2, results in significantly retarded CNS myelination.
The findings suggest that Cyp3a deficiency stimulated the expression of Scap via activation of the AR, which elevated cholesterogenic gene expression levels through activation of SREBP2 and increased total cholesterol contents in the prostate.
SIRT1 (zeige SIRT1 ELISA Kits) gene knock-out may aggravate cartilage degeneration in osteoarthritis by activating the SREBP2 protein-mediated PI3K/AKT (zeige AKT1 ELISA Kits) signalling pathway, suggesting that SIRT1 (zeige SIRT1 ELISA Kits) gene may play a protective role against osteoarthritis.
SREBP-2 is critical for survival and limb patterning during development
Identify a novel signaling pathway in hepatocytes triggered by ligand-activated p75NTR (zeige NGFR ELISA Kits) that via p38 MAPK (zeige MAPK14 ELISA Kits) and caspase-3 (zeige CASP3 ELISA Kits) mediate the activation of SREBP2. This pathway may regulate LDLRs and lipid uptake particularly after injury or during tissue inflammation accompanied by an increased production of growth factors, including NGF (zeige NGFB ELISA Kits) and pro-NGF (zeige NGFB ELISA Kits).
This study reveals SHP (zeige LAMC1 ELISA Kits) as a global transcriptional partner of SREBP-2 in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (zeige FGF19 ELISA Kits).
activation of the sterol regulatory element binding protein-2 (SREBP2) was found to be downstream of ER stress, and this activation was affirmed to account for the intracellular accumulation of cholesterol using RNAi technique
ITCH modulates SIRT6 (zeige SIRT6 ELISA Kits) and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE (zeige APOE ELISA Kits) null mice
SREBP2-induced miR (zeige MLXIP ELISA Kits)-92a targets key molecules in endothelial homeostasis, including sirtuin 1 (zeige SIRT1 ELISA Kits), Kruppel-like factor 2, and Kruppel-like factor 4 (zeige KLF4 ELISA Kits), leading to NOD-like receptor family pyrin domain-containing 3 inflammasome activation and endothelial nitric oxide synthase (zeige NOS3 ELISA Kits) inhibition.
The cholesterol-lowering effects of FGF21 (zeige FGF21 ELISA Kits) are abrogated by hepatic expression of sterol regulatory element-binding protein-2.
Date indicate that sterol regulatory element-binding proteins Srebp1 (zeige SREBF1 ELISA Kits) and Srebp2 are essential for the metabolic reprogramming of NK cells and for the attainment of elevated glycolysis and oxidative phosphorylation.
SREBP-1 (zeige SREBF1 ELISA Kits) and SREBP-2 mRNA expression levels were measured in EAT from 49 patients with CAD (zeige CAD ELISA Kits) (26 with diabetes) and 23 controls without CAD (zeige CAD ELISA Kits) or diabetes.SREBP expression was associated as cardiovascular risk factor for the severity of CAD (zeige CAD ELISA Kits) and the poor lipid control.
High expression of SREBF2 is associated with high carotid intima-media thickness.
mechanistic investigation provides clinical insights into protective roles of the epithelial cholesterol deficiency against excessive inflammatory responses via the SREBP2-HuR (zeige ELAVL1 ELISA Kits) circuit, although the deficiency triggers transient pro-inflammatory signals.
Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells.
Data show that mutant p53 protein (zeige TP53 ELISA Kits) activates the sterol regulatory element-binding proteins SREBP-1 (zeige SREBF1 ELISA Kits) and SREBP-2-mediated signaling pathways in prostate cancer (PCa (zeige FLVCR1 ELISA Kits)) cells.
The connections of EGFR (zeige EGFR ELISA Kits) and ERBB4 (zeige ERBB4 ELISA Kits) signaling with SREBP-2-regulated cholesterol metabolism are likely to be important in ERBB (zeige EGFR ELISA Kits)-regulated developmental processes and may contribute to metabolic remodeling in ERBB (zeige EGFR ELISA Kits)-driven cancers.
Akt1 (zeige AKT1 ELISA Kits) and Akt2 (zeige AKT2 ELISA Kits) activated both SREBP-1 (zeige SREBF1 ELISA Kits) and SREBP-2, whereas Akt3 (zeige AKT3 ELISA Kits) upregulated SREBP-1 (zeige SREBF1 ELISA Kits) to enhance hepatitis C virus translation.
knockdown of endogenous SREBP2 in HepG2 cells lowered ACSL1 (zeige Acsl1 ELISA Kits) mRNA and protein levels.
dysregulation of SIRT1 (zeige SIRT1 ELISA Kits)-AMPK (zeige PRKAA1 ELISA Kits)-SREBP and stimulation of NLRP3 (zeige NLRP3 ELISA Kits) inflammasome may contribute to vascular lipid deposition and inflammation in atherosclerosis
KLF13 (zeige KLF13 ELISA Kits) and SREBP-Sp1 (zeige SP1 ELISA Kits) activation interact to regulate low density lipoprotein receptor (zeige LDLR ELISA Kits) promoter function
This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
sterol regulatory element binding transcription factor 2
, sterol regulatory element-binding protein 2-like
, sterol regulatory element binding protein 2
, sterol regulatory element-binding protein 2
, sterol regulatory element-binding transcription factor 2
, class D basic helix-loop-helix protein 2
, sterol regulatory element binding factor 2