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A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (zeige ATP7A ELISA Kits), sp1 and sod1 (zeige SOD1 ELISA Kits) in zebrafish.
zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
High SP1 (zeige PSG1 ELISA Kits) expression is associated with obesity.
The up-regulation of Hsp27 (zeige HSPB1 ELISA Kits) by E2 is mediated by ERalpha (zeige ESR1 ELISA Kits)/Sp1 (zeige PSG1 ELISA Kits).
Identification of heteromolecular binding sites in transcription factors Sp1 (zeige PSG1 ELISA Kits) and TAF4 (zeige TAF4 ELISA Kits) using high-resolution nuclear magnetic resonance spectroscopy has been reported.
Stimulation of ribosomal RNA gene promoter by transcription factor Sp1 involves active DNA demethylation by Gadd45 (zeige GADD45A ELISA Kits)-NER (zeige NR1H2 ELISA Kits) pathway.
TIP60 (zeige KAT5 ELISA Kits)-mediated growth suppression of HPV-induced cervical cancer is mediated in part due to TERT (zeige TERT ELISA Kits) repression through Sp1 (zeige PSG1 ELISA Kits) acetylation. In summary, our study has identified a novel substrate for TIP60 (zeige KAT5 ELISA Kits) catalytic activity and a unique repressive mechanism acting at the TERT (zeige TERT ELISA Kits) promoter in virus-induced malignancies.
AGEs treatment increased the expression of RAGE (zeige AGER ELISA Kits), Sp1 (zeige PSG1 ELISA Kits), and MMP2 (zeige MMP2 ELISA Kits) in a dose-dependent manner.
E6 upregulation of hTERT by downregulated LKB1 (zeige STK11 ELISA Kits) and upregulated SP1 (zeige PSG1 ELISA Kits) in lung cancer cells. These results indicated that E6 played a predominant role in the regulation of telomerase activation and may be a valuable therapeutic targets for HPV-related cancer.
Results have shown crosstalk among the EGFR (zeige EGFR ELISA Kits) cascade and Sp1 (zeige PSG1 ELISA Kits) and DPD (zeige DPYD ELISA Kits) expressions in EGFR (zeige EGFR ELISA Kits) mutant non-small-cell lung cancer cell lines. EGF (zeige EGF ELISA Kits)-induced Sp1 (zeige PSG1 ELISA Kits) up-regulation resulted in both DPYD (zeige DPYD ELISA Kits) mRNA and DPD (zeige DPYD ELISA Kits) protein expressions.
AKT (zeige AKT1 ELISA Kits)/GSK-3beta (zeige GSK3b ELISA Kits)-mediated stabilization of SP1 (zeige PSG1 ELISA Kits) is required for TGF-beta (zeige TGFB1 ELISA Kits) induced up-regulation of NKG2DLs.
miR-612 has a suppressive role on hepatocellular carcinoma cell stemness via Sp1/Nanog signaling pathway.
study demonstrates the co-expression of DLX3 (zeige DLX3 ELISA Kits), PPARG (zeige PPARG ELISA Kits) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
likely involvement of the Sp family in regulating PTH (zeige PTH ELISA Kits) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN (zeige FASN ELISA Kits) promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
The coordinate regulation of the bovine PRNP (zeige PRNP ELISA Kits) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (zeige PRNP ELISA Kits) promoter and its activity.
Using MA, we demonstrated Sp1 as a critical stemness-related transcriptional factor protecting GBM cells against stress- and TMZ-induced death. Thus, Sp1 inhibition may prevent recurrence of malignant cells persisting after primary therapy.
Results suggest that 25-hydroxycholesterol (25-HC) induced the interaction between NFATc1 (zeige NFATC1 ELISA Kits) and Sp1, reducing the level of free Sp1 to inhibit microRNA miR (zeige MLXIP ELISA Kits)-139-5p expression and promote osteoclastogenesis.
data indicated that (-)-Epicatechin inhibited AngII-induced cardiac hypertrophy by activating the SP1/SIRT1 (zeige SIRT1 ELISA Kits) signaling pathway.
This resulted in Sp1 displacement from the promoter and binding of Sp3 (zeige SP3 ELISA Kits) to it, leading to p300 (zeige NOTCH1 ELISA Kits) recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 (zeige TLR5 ELISA Kits) expression in the intestine. Additionally, a novel insight is gained into Sp1/Sp3 (zeige SP3 ELISA Kits)-mediated gene regulation that may apply to other genes
adrenergic stimulation induced complex formation between Ifrd1 (zeige IFRD1 ELISA Kits), Sp1 and mSIN3B, which is a component of the SIN complex containing histone deacetylase (zeige HDAC1 ELISA Kits), in brown adipocytes. These findings, therefore, suggest that Ifrd1 (zeige IFRD1 ELISA Kits) could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.
Dp71 (zeige DMD ELISA Kits) expression in hepatic cells is carried out, in part, by YY1 (zeige YY1 ELISA Kits)-, Sp1- and Sp3 (zeige SP3 ELISA Kits)-mediated transcription from the Dp71 (zeige DMD ELISA Kits) promoter.
SP1 expression was up-regulated in the tubular epithelial cells after acute kidney injury induced by ischemia-reperfusion.MiR-204 regulates epithelial-mesenchymal transition by targeting SP1 in the tubular epithelial cells.
miR (zeige MLXIP ELISA Kits)-124, -128, and -137 act synergistically to regulate Sp1 expression.
YY1 and SP1 independently and cooperatively govern the Mesp1 expression during embryogenesis.
Taken together, these results indicate that the transcription factor Sp1 upregulates the proximal promoter activity of the mouse Col11a1 (zeige COL11A1 ELISA Kits) gene in chondrocytes.
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
, transcription factor Sp1
, transcription factor
, Sp1 transcription factor
, transcription factor Sp1-like
, specificity protein 1
, specific protein-1
, trans-acting transcription factor 1