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PLIN2 gene Ser251Pro missense mutation is associated with reduced insulin (zeige INS ELISA Kits) secretion and increased insulin (zeige INS ELISA Kits) sensitivity.
Interference with PLIN2 and PPARalpha (zeige PPARA ELISA Kits) resulted in major alterations in gene expression, especially affecting lipid, glucose, and purine metabolism.
This study shows that hepatitis C virus suppresses hepatic ADRP expression in infected patients and cell lines. Forcing the expression of miR (zeige MLXIP ELISA Kits)-148a and miR (zeige MLXIP ELISA Kits)-30a limits the suppressive effect of hepatitis C virus on ADRP.
ADP was expressed in a small proportion of lung adenocarcinoma suggesting that ADP-positive lung adenocarcinoma could be a distinct subtype of lung adenocarcinoma, induced by up-regulation of the lipogenic pathway.
Activation of ARF1 (zeige ARF1 ELISA Kits) dissociates ADRP from lipid droplets. A constitute active form of ARF1 (zeige ARF1 ELISA Kits) (ARF1Q71I) promotes HCV assembly. ADRP played a positive role in Hepatitis C virus replication and negative role in Hepatitis C virus assembly.
PLIN2 expression is significantly upregulated in human masticatory mucosa during wound healing
Adipophilin was present in 24 of 26 colorectal hyperplastic polyps, but did not correlate with presence of white opaque substance (i.e. lipid droplets) on magnifying endoscopy with narrow band imaging.
Conserved amphipathic helices mediate lipid droplet targeting of PLIN1 (zeige PLIN1 ELISA Kits), PLIN2, and PLIN3 (zeige PLIN3 ELISA Kits).
In hepatitis C virus -infected human livers, occludin (zeige OCLN ELISA Kits) and ADRP mRNA expression levels correlated with each other. Hepatitis C virus increases occludin (zeige OCLN ELISA Kits) expression via the upregulation of ADRP.
PLIN2 involves lipid modulation of GSK3 (zeige GSK3b ELISA Kits) activity, GSK3 (zeige GSK3b ELISA Kits) substrate expression, and cell growth/survival.
Although lipopolysaccharide (LPS (zeige TLR4 ELISA Kits)) can trigger inflammation in atherosclerosis, how LPS (zeige TLR4 ELISA Kits) promotes atherogenesis through acting on macrophages is not very clear. Here, we study the role of adipophilin in LPS (zeige TLR4 ELISA Kits)-induced inflammation. LPS (zeige TLR4 ELISA Kits) can promote the expression of adipophilin through the ERK1/2 (zeige MAPK1/3 ELISA Kits)-PPARgamma (zeige PPARG ELISA Kits) pathway.
Cardiac PLIN2 plays an important pathophysiological role in the development of dynamic steatosis and that the latter was prevented by upregulation of intracellular lipases, including Hormone-sensitive Lipase (zeige LIPE ELISA Kits).
Plin2 liver-specific ablation alleviates diet-induced hepatic steatosis and inflammation via a PEMT (zeige PEMT ELISA Kits)-mediated mechanism.
The relationship between M1-/M2-macrophage polarization and Adp-rich hepatocyte-consisting pseudolobules (PLs (zeige CTSC ELISA Kits)) was investigated in thioacetamide (TAA)-induced rat cirrhosis.
results identify PLIN2 as a determinant of global changes in the hepatic lipidome and suggest the hypothesis that these actions contribute to SREBP-regulated de novo lipogenesis involved in non-alcoholic fatty liver disease.
Taken together, these findings demonstrate that artesunate inhibits adipogenesis in 3T3-L1 preadipoytes through the reduced expression and/or phosphorylation levels of C/EBP-alpha (zeige CEBPA ELISA Kits), PPAR-gamma (zeige PPARG ELISA Kits), FAS (zeige FAS ELISA Kits), perilipin A (zeige PLIN1 ELISA Kits), and STAT-3 (zeige STAT3 ELISA Kits).
phosphorylation of PLIN2 is dependent on AMPK (zeige PRKAA1 ELISA Kits) and occurs after the interaction of PLIN2 with the chaperone-mediated autophagy chaperone HSPA8/Hsc70 (zeige HSPA8 ELISA Kits).
demonstrate a mutually beneficial relationship between PLIN2 deficiency and elevated apoA-I (zeige APOA1 ELISA Kits)/HDL (zeige HSD11B1 ELISA Kits)-C in preventing atherosclerosis development
our findings highlight the relationship between protein stability and a previously unnoticed function of Plin2 during lipolysis in adipocytes.
These results demonstrate that bovine embryos at the blastocyst stage expressed ADRP mRNA and protein, and that the embryonic culture system modified this expression.
Adipophilin and TIP47 (zeige PLIN3 ELISA Kits) are expressed in lipid droplets of vitamin A-storing hepatic stellate cells and additionally in lipid droplets of steatotic hepatocytes.
25 novel polymorphisms were identified within all exons and their flanking regions of ADFP, including the promoter region.
PLIN1 (zeige PLIN1 ELISA Kits) and PLIN2 have been evaluated as candidate genes for growth, carcass and meat quality traits in pigs; two single-nucleotide polymorphisms, one in intron 2 of the PLIN1 (zeige PLIN1 ELISA Kits) gene (JN860199:g.173G>A) and the 3' untranslated region of the PLIN2 gene (GU461317:g.98G>A); results obtained indicate that the PLIN2 polymorphism could be a useful marker for lean growth.
These findings suggested that PLIN2 was a major lipid droplet-associated protein (zeige PLIN1 ELISA Kits) in porcine oocytes.
In pig muscle PLIN1 (zeige PLIN1 ELISA Kits) and PLIN2 proteins are localized in correspondence with extra and intra-myocellular lipids, respectively.
PLIN2 can be a marker for carcass quality in pigs.
The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene.
, adipose differentiation-related protein
, adipose differentiation related protein
, perilipin 2
, adipocyte differentiation-related protein