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Mouse (Murine) NRF1 ELISA Kit für Sandwich ELISA - ABIN819118
Choi, Suh, Rhee, Kim: Sciadopitysin alleviates methylglyoxal-mediated glycation in osteoblastic MC3T3-E1 cells by enhancing glyoxalase system and mitochondrial biogenesis. in Free radical research 2014
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our investigation shows that the ER membrane protein TCF11/Nrf1 (zeige NFE2L1 ELISA Kits) is an essential component of the cellular stress response mechanism. In response to cytotoxic stress, TCF11/Nrf1 (zeige NFE2L1 ELISA Kits) is retrotranslocated and transferred to the nucleus where it induces proteasome subunit expression via binding to the ARE region of the relevant promoter.
Deficiency of long isoforms of Nfe2l1 in pancreatic beta-cells increased susceptibility to acute arsenite-induced cytotoxicity by promoting arsenic biotransformation and intracellular MMA levels.
Nrf1 knockdown suppressed the death of ubiquitin-deficient N2a cells upon exposure to As(III). Therefore, the levels of p65 (zeige NFkBP65 ELISA Kits)-Nrf1 may play an important role in the maintenance of cell viability under oxidative stress induced (zeige SQSTM1 ELISA Kits) by As(III).
findings suggest that neurodegeneration in Nrf1 NKO mice may stem from the dysfunction of the ubiquitin-mediated regulation of neuronal proteins
Our findings demonstrate that DEE and a fraction derived from this extract exerts anti-inflammatory effects through Nrf2dependent HO-1 (zeige HMOX1 ELISA Kits) expression
NRF1 (nuclear respiratory factor 1) is a methylation-sensitive transcription factor; in the absence of DNA methylation (zeige HELLS ELISA Kits), NRF1 binds to new sites and induces aberrant transcription
Nrf1 plays critical roles in regulating glucose metabolism, mitochondrial function, and insulin (zeige INS ELISA Kits) secretion, suggesting that Nrf1 may be a novel target to improve the function of insulin (zeige INS ELISA Kits)-secreting beta-cells.
Nrf1 is negatively regulated by its O-GlcNAcylation status that depends on the glucose concentrations
lysine-specific demethylase (zeige MBD2 ELISA Kits) 1 promotes oxidative phosphorylation in white adipose tissue, in cooperation with Nrf1.
Results show that Nrf1 may not be directly responsible for (zeige GCLC ELISA Kits) the loss (zeige GCLM ELISA Kits) of Nrf2-dependent inducibility of a (zeige HBe1 ELISA Kits)ntioxidant and cytoprotective genes observed in aged animals.
Here the authors show that the aspartyl protease (zeige REN1 ELISA Kits) DNA-damage inducible 1 homolog 2 (DDI2) is required to cleave and activate Nrf1 (zeige NFE2L1 ELISA Kits).
this study therefore identifies NRF-1 (zeige NFE2L1 ELISA Kits) as a novel regulator of HIF-1a (zeige HIF1A ELISA Kits).
These results uncover a new regulatory mechanism that USP15 (zeige USP15 ELISA Kits) activates Nrf1 (zeige NFE2L1 ELISA Kits) against the beta-TrCP (zeige BTRC ELISA Kits) inhibition to maintain proteostasis.
NRF-1 (zeige NFE2L1 ELISA Kits) and its target mitochondrial transcription factor A (TFAM (zeige TFAM ELISA Kits)) were higher in Tamoxifen (TAM (zeige CCNA1 ELISA Kits))-resistant LCC2 and LCC9 cells than TAM (zeige CCNA1 ELISA Kits)-sensitive MCF-7 cells.
NRF1 (zeige NFE2L1 ELISA Kits) overexpression attenuated BPDEinduced Sphase arrest via the ATM (zeige ATM ELISA Kits)/Chk2 (zeige CHEK2 ELISA Kits) signaling pathway.
Importantly, Nrf1 activity is positively and/or negatively regulated by distinct doses of proteasome and calpain inhibitors
Low NRF1 (zeige NFE2L1 ELISA Kits) expression was associated lymphatic metastasis and radio-resistance in nasopharyngeal carcinoma.
EglN2 (zeige EGLN2 ELISA Kits) associates with the NRF1 (zeige NFE2L1 ELISA Kits)-PGC1alpha complex and controls mitochondrial function in breast cancer
Lack of aprataxin (zeige APTX ELISA Kits) impairs mitochondrial functions via downregulation of the APE1 (zeige APEX1 ELISA Kits)/NRF1 (zeige NFE2L1 ELISA Kits)/NRF2 (zeige GABPA ELISA Kits) pathway.
Transcription Factor A (zeige GTF3A ELISA Kits) expression associated with mitochondrial biogenesis activation & high levels of NRF1 mRNA from oocyte stage onwards argue for essential function of these factors during 1st steps of bovine embryogenesis
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1.
nuclear respiratory factor 1
, nuclear respiratory factor-1
, NF-E2-related factor 1
, NFE2-related factor 1
, nuclear factor erythroid 2-related factor 1
, alpha palindromic-binding protein
, not really finished protein
, transcription factor