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Chicken Polyclonal NRF1 Primary Antibody für IHC (p), ELISA - ABIN5326807
Morrish, Giedt, Hockenbery: c-MYC apoptotic function is mediated by NRF-1 target genes. in Genes & development 2003
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Human Polyclonal NRF1 Primary Antibody für IF (p), IHC (p) - ABIN675219
Qin, Wang, Huo, Yan, Jiang, Zhou, Wang, Sang: Sulfur dioxide inhalation stimulated mitochondrial biogenesis in rat brains. in Toxicology 2012
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Human Monoclonal NRF1 Primary Antibody für IHC (p), RNAi - ABIN2752368
Thompson, MacDonald, Mueller: Decreased expression of BRCA1 in SK-BR-3 cells is the result of aberrant activation of the GABP Beta promoter by an NRF-1-containing complex. in Molecular cancer 2011
Cow (Bovine) Polyclonal NRF1 Primary Antibody für IHC, WB - ABIN2775850
Teodoro, Duarte, Gomes, Varela, Peixoto, Rolo, Palmeira: Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: a possible role for SirT3 activation. in Mitochondrion 2013
Human Polyclonal NRF1 Primary Antibody für ICC, IF - ABIN4340686
Sotgia, Whitaker-Menezes, Martinez-Outschoorn, Salem, Tsirigos, Lamb, Sneddon, Hulit, Howell, Lisanti: Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. in Cell cycle (Georgetown, Tex.) 2012
Study identifies the endoplasmic reticulum (ER)-bound transcription factor nuclear factor erythroid 2 related factor-1 (zeige NFE2L1 Antikörper), Nrf1/Nfe2L1 (zeige NFE2L1 Antikörper), as a critical mediator of this process and shows that Nrf1 directly binds to and specifically senses cholesterol in the ER through a defined domain and that cholesterol regulates Nrf1 turnover, processing, localization, and activity.
data highlight a precise crosstalk between transcriptional regulation by NRF1 and epigenetic modulation during germ cell development and unequivocally demonstrate a novel role of NRF1 in spermatogenesis
our investigation shows that the ER membrane protein TCF11/Nrf1 (zeige NFE2L1 Antikörper) is an essential component of the cellular stress response mechanism. In response to cytotoxic stress, TCF11/Nrf1 (zeige NFE2L1 Antikörper) is retrotranslocated and transferred to the nucleus where it induces proteasome subunit expression via binding to the ARE region of the relevant promoter.
Deficiency of long isoforms of Nfe2l1 in pancreatic beta-cells increased susceptibility to acute arsenite-induced cytotoxicity by promoting arsenic biotransformation and intracellular MMA levels.
Nrf1 knockdown suppressed the death of ubiquitin-deficient N2a cells upon exposure to As(III). Therefore, the levels of p65 (zeige NFkBP65 Antikörper)-Nrf1 may play an important role in the maintenance of cell viability under oxidative stress induced (zeige SQSTM1 Antikörper) by As(III).
findings suggest that neurodegeneration in Nrf1 NKO mice may stem from the dysfunction of the ubiquitin-mediated regulation of neuronal proteins
Our findings demonstrate that DEE and a fraction derived from this extract exerts anti-inflammatory effects through Nrf2dependent HO-1 (zeige HMOX1 Antikörper) expression
NRF1 (nuclear respiratory factor 1) is a methylation-sensitive transcription factor; in the absence of DNA methylation (zeige HELLS Antikörper), NRF1 binds to new sites and induces aberrant transcription
Nrf1 plays critical roles in regulating glucose metabolism, mitochondrial function, and insulin (zeige INS Antikörper) secretion, suggesting that Nrf1 may be a novel target to improve the function of insulin (zeige INS Antikörper)-secreting beta-cells.
Nrf1 is negatively regulated by its O-GlcNAcylation status that depends on the glucose concentrations
Chronic kidney disease patients undergoing hemodialysis might be subjected to potential mitochondrial oxidative dysregulation and NRF1 (zeige NFE2L1 Antikörper) down-regulation.
Here the authors show that the aspartyl protease (zeige REN1 Antikörper) DNA-damage inducible 1 homolog 2 (DDI2) is required to cleave and activate Nrf1 (zeige NFE2L1 Antikörper).
this study therefore identifies NRF-1 (zeige NFE2L1 Antikörper) as a novel regulator of HIF-1a (zeige HIF1A Antikörper).
These results uncover a new regulatory mechanism that USP15 (zeige USP15 Antikörper) activates Nrf1 (zeige NFE2L1 Antikörper) against the beta-TrCP (zeige BTRC Antikörper) inhibition to maintain proteostasis.
NRF-1 (zeige NFE2L1 Antikörper) and its target mitochondrial transcription factor A (TFAM (zeige TFAM Antikörper)) were higher in Tamoxifen (TAM (zeige CCNA1 Antikörper))-resistant LCC2 and LCC9 cells than TAM (zeige CCNA1 Antikörper)-sensitive MCF-7 cells.
NRF1 (zeige NFE2L1 Antikörper) overexpression attenuated BPDEinduced Sphase arrest via the ATM (zeige ATM Antikörper)/Chk2 (zeige CHEK2 Antikörper) signaling pathway.
Importantly, Nrf1 activity is positively and/or negatively regulated by distinct doses of proteasome and calpain inhibitors
Low NRF1 (zeige NFE2L1 Antikörper) expression was associated lymphatic metastasis and radio-resistance in nasopharyngeal carcinoma.
EglN2 (zeige EGLN2 Antikörper) associates with the NRF1 (zeige NFE2L1 Antikörper)-PGC1alpha complex and controls mitochondrial function in breast cancer
Transcription Factor A (zeige GTF3A Antikörper) expression associated with mitochondrial biogenesis activation & high levels of NRF1 mRNA from oocyte stage onwards argue for essential function of these factors during 1st steps of bovine embryogenesis
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1.
nuclear respiratory factor 1
, nuclear respiratory factor-1
, NF-E2-related factor 1
, NFE2-related factor 1
, nuclear factor erythroid 2-related factor 1
, alpha palindromic-binding protein
, not really finished protein
, transcription factor