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Data indicate that specific cancer-driving nodes are generally under NF-YA (zeige NFYA ELISA Kits)/B control.
NF-YB transcription factor was identified as a novel direct E2F1 (zeige E2F1 ELISA Kits) target.
The NF-Y complex is asymmetric, with NF-YB binding approximately 15 bp downstream from the CCAAT motif.
The crystal structure of NF-Y bound to a 25 bp CCAAT oligonucleotide shows that the histone-fold domains dimer binds to the DNA sugar-phosphate backbone, mimicking the nucleosome H2A/H2B-DNA assembly; NF-YA (zeige NFYA ELISA Kits) both binds to NF-YB/NF-YC (zeige NFYC ELISA Kits) and inserts an alpha helix deeply into the DNA minor groove, providing sequence-specific contacts to the CCAAT box.
Transcriptional repression mediated by IER5 (zeige IER5 ELISA Kits) regulates Cdc25B (zeige CDC25B ELISA Kits) expression levels via the release of NF-YB and p300 (zeige EP300 ELISA Kits) in acute myeloid leukemia (zeige BCL11A ELISA Kits).
NF-Y acts upstream of H3K4me3 deposition by recruiting Ash2L
The NF-YB/NF-YC (zeige NFYC ELISA Kits) structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y.
p300 (zeige EP300 ELISA Kits) binds to multiple NF-Y trimers to regulate cyclin B2 (zeige CCNB2 ELISA Kits) promoter function
CBF (zeige CEBPZ ELISA Kits)/NF-Y proteins regulate the transcription of COL11A1 (zeige COL11A1 ELISA Kits) by directly binding to the ATTGG sequence in the proximal promoter region
Histone deacetylase (zeige HDAC1 ELISA Kits) inhibitors can induce Gadd45 (zeige GADD45A ELISA Kits) through its promoter without the need for functional p53 (zeige TP53 ELISA Kits), and both Oct-1 (zeige POU2F1 ELISA Kits) and NF-Y concertedly participate in trichostatin A-induced activation of the gadd45 (zeige GADD45A ELISA Kits) promoter.
results exclude NFYB as candidate gene for congenital splay leg but provide a basis for selection of further candidates for the disease from SSC5
deletion of CBF-B (zeige NFYA ELISA Kits) activated expression of specific endoplasmic reticulum stress-regulated genes. Inactivation of CBF-B (zeige NFYA ELISA Kits) also inhibited expression of C/EBP alpha (zeige CEBPA ELISA Kits), an important transcription factor controlling metabolic processes in adult hepatocytes
p73 (zeige ARHGAP24 ELISA Kits) and DeltaNp73 behave as physiological regulators for recruitment of histone deacetylase (zeige HDAC1 ELISA Kits) to NF-Y and transcription of the PDGFRB (zeige PDGFRB ELISA Kits) promoter
CBF-A (zeige CEBPA ELISA Kits) is a novel transacting factor required for cytoplasmic mRNA transport and localization
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence\; protein sequence alignments and experiments with mutants.
nuclear transcription factor Y, beta
, nuclear transcription factor Y subunit beta
, CAAT box DNA-binding protein subunit B
, CCAAT-binding transcription factor subunit A
, Transcription factor NF-Y, B subunit
, nuclear transcription factor Y subunit B
, nuclear Y/CCAAT-box binding factor B subunit NF-YB
, CAAT-box DNA binding protein subunit B (NF-YB)
, CAAT-box DNA-binding protein subunit B
, nuclear transcription factor Y beta
, CCAAT binding transcription factor of CBF-B/NFY-B
, nuclear transcription factor - Y beta