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Vif (zeige BTG1 ELISA Kits) proteins of human and simian immunodeficiency viruses require cellular CBFbeta to degrade APOBEC3G (zeige APOBEC3G ELISA Kits).
simian immunodeficiency virus (SIV) Vif (zeige BTG1 ELISA Kits) binds to and requires CBF-beta to degrade rhesus macaque APOBEC3G (zeige APOBEC3G ELISA Kits)
High CBFB expression is associated with leukemia.
Vif (zeige BTG1 ELISA Kits) stabilization by CBFbeta is mainly caused by impairing MDM2 (zeige MDM2 ELISA Kits)-mediated degradation.
the mechanistic view that the proliferative function of Crlz-1 (zeige UTP3 ELISA Kits) is caused by relaying Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) to pre-B cell receptor signaling pathways through the regulation of Runx/CBFbeta heterodimerization was verified
Core binding factor beta deficiency in chondrocytes caused a decrease of protein levels of Runx transcription factors by accelerating polyubiquitination-mediated proteosomal degradation in vitro
Cbfb plays an important role in the stabilization of Runx family proteins; and that Runx2 (zeige RUNX2 ELISA Kits) protein stability is less dependent on Cbfb in calvariae than in cartilaginous limb skeletons
findings indicate that Cbfbeta stabilizes Runx2 (zeige RUNX2 ELISA Kits) in osteoblasts by forming a complex and thus facilitates the proper maintenance of bone mass, particularly cortical bone
Runx/Cbfb signaling regulate androgen receptor (zeige AR ELISA Kits) pathway, but does not affect the circulating testosterone levels or the enzymatic conversion to DHT.
Cbfb deficiency results in differentiation blocks and stem cell expansion in hematopoiesis.
Cbfbeta functions in upregulating Ihh (zeige IHH ELISA Kits) expression to promoter chondrocyte proliferation and osteoblast differentiation, and inhibiting PPR (zeige PTH1R ELISA Kits) expression to enhance chondrocyte differentiation.
results demonstrate that Cbfbeta mediates cartilage and bone development by interacting with Runx1 (zeige RUNX1 ELISA Kits) and Runx2 (zeige RUNX2 ELISA Kits) to regulate the expressions of Col (zeige HDAC1 ELISA Kits) X and Osx (zeige SP7 ELISA Kits) for chondrocyte and osteoblast development
In neuronal fate determination, Runx co-factor Cbfbeta is essential for its function, but the high level of Runx3 (zeige RUNX3 ELISA Kits) expression can overcome the loss of Cbfbeta, demonstrating that Cbfbeta in this context serves solely as a signal amplifier of Runx3 (zeige RUNX3 ELISA Kits) activity.
characterization of cbfbeta gene
Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development
Data demonstrate for the first time an essential role of JunB (zeige JUNB ELISA Kits)-CBFbeta signaling for maintaining sarcomere architecture and function.
discussion of the role of CBFB in diseases caused by their mutations or deletions (review)
The co-existence of BCR (zeige BCR ELISA Kits)-ABL1 (zeige ABL1 ELISA Kits) and CBFB rearrangement is associated with poor outcome and a clinical course similar to that of CML (zeige BCR ELISA Kits)-BP, and unlike de novo AML (zeige RUNX1 ELISA Kits) with CBFB rearrangement, suggesting that high-intensity chemotherapy with TKI should be considered in these patients.
Moreover, using a CBF-beta loss-of-function mutant, the authors demonstrated that the interaction between CBF-beta and Vif (zeige BTG1 ELISA Kits) was not sufficient for Vif (zeige BTG1 ELISA Kits) assistance; a region including F68 in CBF-beta was also required for the stability and function of Vif (zeige BTG1 ELISA Kits).
Mutational analysis of CBFbeta revealed that F68 and I55 (zeige FBXL14 ELISA Kits) residues are important and participate in a tripartite hydrophobic interaction with W5 of Vif (zeige BTG1 ELISA Kits) to maintain a stable and functional Vif (zeige BTG1 ELISA Kits)-CBFbeta complex.
Thus, an NGF (zeige NGFB ELISA Kits)/TrkA (zeige NTRK1 ELISA Kits)-MAPK (zeige MAPK1 ELISA Kits)-CBFbeta pathway converges with Islet1 (zeige ISL1 ELISA Kits)-Runx1 (zeige RUNX1 ELISA Kits) signaling to promote Runx1 (zeige RUNX1 ELISA Kits)/CBFbeta holocomplex formation and nonpeptidergic nociceptor maturation.
Our findings demonstrate that HSPCs exposed to non-cytotoxic levels of environmental chemicals and chemotherapeutic agents are prone to topoisomerase II (zeige TOP2 ELISA Kits)-mediated DNA damage at the leukemia-associated genes MLL (zeige MLL ELISA Kits) and CBFB.
These results provide important information on the assembly of the Vif (zeige BTG1 ELISA Kits)-CUL5 (zeige CUL5 ELISA Kits)-E3 ubiquitin ligase and identify a new viV binding interface with CBF-beta at the C-terminus of HIV-1 Vif (zeige BTG1 ELISA Kits).
CBF-beta promoted steady-state levels of HIV-1 Vif (zeige BTG1 ELISA Kits) by inhibiting the degradation of HIV-1 Vif (zeige BTG1 ELISA Kits) through the proteasome pathway.
CBFB contributes to the transcriptional regulation of ribosomal gene expression and provide further understanding of the epigenetic role of CBFB-SMMHC (zeige MYH11 ELISA Kits) in proliferation and maintenance of the leukemic phenotype.
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit\; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16
core binding factor beta
, core-binding factor subunit beta
, core-binding factor, beta subunit
, core binding factor beta subunit
, SL3-3 enhancer factor 1 subunit beta
, SL3/AKV core-binding factor beta subunit
, polyomavirus enhancer-binding protein 2 beta subunit
, CCAAT-binding transcription factor subunit B
, core-binding factor beta
, SL3-3 enhancer factor 1 beta subunit
, polyomavirus enhancer binding protein 2, beta subunit
, CAAT box DNA-binding protein subunit A
, CAAT-box DNA-binding protein subunit A
, nuclear transcription factor Y subunit A
, nuclear transcription factor Y subunit alpha
, CAAT box DNA-binding protein subunit B
, CAAT-box DNA-binding protein subunit B
, CCAAT binding transcription factor of CBF-B/NFY-B
, CCAAT-binding transcription factor subunit A
, nuclear transcription factor - Y beta
, nuclear transcription factor Y subunit B
, nuclear transcription factor Y subunit beta