Apolipoprotein A-I Proteine (APOA1)

Bezeichnung:
Apolipoprotein A-I Proteine (APOA1)
Auf www.antikoerper-online.de finden Sie aktuell 100 Apolipoprotein A-I (APOA1) Proteine von 18 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Apolipoprotein A-I Antikörper (550) und Apolipoprotein A-I Kits (108) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 780 Apolipoprotein A-I Produkte verfügbar.
Synonyme:
Alp-1, Apo-AI, apoa, Apoa-1, apoA-I, apoa1, ApoAI, Brp-14, cb49, LOC100136573, Ltw-1, Lvtw-1, MGC64335, MGC89745, Sep-1, Sep-2, Sep2, wu:fb33f01, zgc:103718
alle Proteine anzeigen Gen GeneID UniProt
APOA1 335 P02647
APOA1 11806 Q00623
APOA1 25081 P04639

Weitere Synonyme anzeigen

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Am meisten referenzierte Apolipoprotein A-I Proteine

  1. Human APOA1 Protein expressed in Escherichia coli (E. coli) - ABIN2003220 : Soutar, Hawkins, Vigushin, Tennent, Booth, Hutton, Nguyen, Totty, Feest, Hsuan: Apolipoprotein AI mutation Arg-60 causes autosomal dominant amyloidosis. in Proceedings of the National Academy of Sciences of the United States of America 1992 (PubMed)
    Zeige alle 4 Referenzen für 2003220

  2. Human APOA1 Protein expressed in Escherichia coli (E. coli) - ABIN413012 : Barlic, Zhu, Murphy: Atherogenic lipids induce high-density lipoprotein uptake and cholesterol efflux in human macrophages by up-regulating transmembrane chemokine CXCL16 without engaging CXCL16-dependent cell adhesion. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)
    Zeige alle 3 Referenzen für 413012

  3. Mouse (Murine) APOA1 Protein expressed in Human Cells - ABIN2008404 : Eggerman, Hoeg, Meng, Tombragel, Bojanovski, Brewer: Differential tissue-specific expression of human apoA-I and apoA-II. in Journal of lipid research 1991 (PubMed)
    Zeige alle 3 Referenzen für 2008404

  4. Human APOA1 Protein expressed in Escherichia coli (E. coli) - ABIN667126 : Khadem-Ansari, Rasmi, Rahimi-Pour, Jafarzadeh: The association between serum apolipoprotein A-I and apolipoprotein B and the severity of angiographical coronary artery disease. in Singapore medical journal 2009 (PubMed)
    Zeige alle 2 Referenzen für 667126

Weitere Proteine zu Apolipoprotein A-I Interaktionspartnern

Human Apolipoprotein A-I (APOA1) Interaktionspartner

  1. Findings suggest that the ABCG1 (zeige ABCG1 Proteine)-mediated efflux of cholesterol, but not of 7-ketocholesterol, shows specificity for structural domains of apoA-I bound to reconstituted HDL (zeige HSD11B1 Proteine). Although the mid region alone of apoA-I associated to rHDL can promote ABCG1 (zeige ABCG1 Proteine)-mediated cholesterol efflux, deletion of carboxyl-terminal region 185-243 from full-length apoA-I diminishes ABCG1 (zeige ABCG1 Proteine)-mediated cholesterol efflux.

  2. Low APOA1 expression is associated with coronary artery disease severity.

  3. Data suggest that activation of SR-BI (zeige SCARB1 Proteine) by APOAI down-regulates sphingosine 1-phosphate/S1PR2 (zeige S1PR2 Proteine)-mediated inflammation in vascular endothelial cells by activating the PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling pathway; oxidized-LDL does the opposite. (APOA1 = apolipoprotein A-I; SR-BI/SCARB1 (zeige SCARB1 Proteine) = scavenger receptor class B type I; S1PR2 (zeige S1PR2 Proteine) = sphingosine 1-phosphate receptor 2 (zeige S1PR2 Proteine); PI3K (zeige PIK3CA Proteine) = phosphatidylinositol 3-kinase; Akt (zeige AKT1 Proteine) = proto-oncogene c-akt (zeige AKT1 Proteine))

  4. The minor alleles of rs662799 (APOA5 (zeige APOA5 Proteine)) and rs5072 (APOA1) modulate TG levels in Mexican children

  5. Objective of this study was to understand their structural and functional role by generating domain swapped chimeras: apoE3-N-terminal/apoAI-C-terminal and apoAI-N-terminal/apoE (zeige APOE Proteine)-C-terminal. Results indicate that the functional attributes of apoAI and apoE3 can be conferred on each other and that N-terminal-C-terminal domain interactions significantly modulate their structure and function.

  6. These data demonstrate that complex of PPARgamma (zeige PPARG Proteine) with GW1929 is a negative regulator involved in the control of ApoA-I expression and secretion in human hepatocyte- and enterocyte-like cells

  7. Human apoA-I was overexpressed by transfection in BEL (zeige LHX2 Proteine)-7402 hepatocytes and by an adenoviral vector in C57BL/6J mice fed a methionine choline-deficient diet. The overexpression of apoA-I in both models resulted in decreased reactive oxygen species and lipid peroxidation levels, as well as a reduced MAPK (zeige MAPK1 Proteine) phosphorylation and decreased expression levels of c-Fos and COX-2.

  8. The H10B sequence repeat of lipid-free human apoA-I is vital in HDL (zeige HSD11B1 Proteine) formation.

  9. Our results assign a novel role for 4F(apoA-I mimetic peptide ) as a modulator of the TICE pathway and suggest that the anti-inflammatory functions of 4F may be a partial consequence of the codependent intestinal transport of both 4F and cholesterol.

  10. these data highlight a key role of the P2Y1 (zeige P2RY1 Proteine)/PI3Kbeta axis in endothelial cell proliferation downstream of ecto (zeige TRIM33 Proteine)-F1-ATPase activation by apoA-I. Pharmacological targeting of this pathway could represent a promising approach to enhance vascular endothelial protection.

Mouse (Murine) Apolipoprotein A-I (APOA1) Interaktionspartner

  1. apoA-I/ABCA1 (zeige ABCA1 Proteine)-mediated cholesterol efflux without STAT3 (zeige STAT3 Proteine) activation can reduce proinflammatory cytokine expression in macrophages.

  2. a novel protective role for ApoA-I in colitis and CAC (zeige SLC25A20 Proteine)

  3. Our results assign a novel role for 4F(apoA-I mimetic peptide ) as a modulator of the TICE pathway and suggest that the anti-inflammatory functions of 4F may be a partial consequence of the codependent intestinal transport of both 4F and cholesterol.

  4. Preincubation of endothelial cells with apoA-I protected against the TNF-alpha (zeige TNF Proteine)-induced inhibition of HTR (zeige F2R Proteine)-8/SVneo (trophoblast) cell integration into endothelial (UtMVEC) networks. These data suggest that a healthy lipid profile may affect pregnancy outcomes by priming endothelial cells in preparation for trophoblast invasion.

  5. Reductions in Dio1 (zeige DIO1 Proteine) expression reduce the expression of ApoA-I in a 3,5,3'-triiodothyronine-/thyroid hormone (zeige PTH Proteine) response element-independent manner.

  6. apoA-1 deficiency generates changes in the bone cell precursor population that increase adipoblast, and decrease osteoblast production resulting in reduced bone mass and impaired bone quality

  7. This study suggests that enhancement of macrophage cholesterol metabolism by PPARgammais not contributed by activating ABCA1 (zeige ABCA1 Proteine) expression and ABCA1 (zeige ABCA1 Proteine)-mediated cholesterol efflux to apoAI, which is not involved by CD36 (zeige CD36 Proteine) expression either.

  8. Mass spectrometry analysis of peptides derived from chemically crosslinked HDL (zeige HSD11B1 Proteine)-SAA (zeige SAA1 Proteine) particles detected multiple crosslinks between apoA1 and SAA (zeige SAA1 Proteine), indicating close proximity (within 25 A) of these two proteins on the HDL (zeige HSD11B1 Proteine) surface, providing a molecular and structural mechanism for the simultaneous binding of heparin to apoA1 and SAA (zeige SAA1 Proteine).

  9. results demonstrate that double deletion of Apoe (zeige APOE Proteine) and Apoa1 ameliorated the amyloid pathology.

  10. study suggests that apolipoprotein a1 can alleviate obesity related metabolic disease by inducing AMPK (zeige PRKAA1 Proteine) dependent mitochondrial biogenesis.

Pig (Porcine) Apolipoprotein A-I (APOA1) Interaktionspartner

  1. Alterations in the Apo A (zeige APOA Proteine)-I pattern is a good indicator of the presence and severity of infectious diseases in the pig.Lower overall amounts of Apo A (zeige APOA Proteine)-I were observed in Salmonella typhimurium and Escherichia coli infections.

  2. down-regulation of apolipoprotein A-I and A-IV messages in the liver may be mediated by interleukin 6 (zeige IL6 Proteine) and tumor necrosis factor-alpha (zeige TNF Proteine)

Rabbit Apolipoprotein A-I (APOA1) Interaktionspartner

  1. This study showed that apoA-I exerted protective effects against fatty liver disease in rabbits induced by a high-fat diet, possibly through its antioxidant actions.

  2. The molar ratio ApoE (zeige APOE Proteine)/ApoA-I is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.

Cow (Bovine) Apolipoprotein A-I (APOA1) Interaktionspartner

  1. Binding of apoA-I to ectopic F(0)F(1) ATPase (zeige ATP5E Proteine) triggers the generation of ADP, which via activation of the purinergic receptor P2Y (zeige P2RY1 Proteine)(12) stimulates the uptake and transport of HDL (zeige HSD11B1 Proteine) and initially lipid-free apoA-I by endothelial cells.

  2. the model of a two-step process for the transendothelial transport of apoA-I in which apoA-I is initially lipidated by ABCA1 (zeige ABCA1 Proteine) and then further processed by ABCA1 (zeige ABCA1 Proteine)-independent mechanisms.

Zebrafish Apolipoprotein A-I (APOA1) Interaktionspartner

  1. insulin (zeige INS Proteine) secretion and tissue rejuvenation activities of WT-reconstituted high-density lipoproteins were nearly depleted by fructosylation, but V156K-rHDL did not lose its beneficial activity.

  2. The NABB system using engineered zebrafish apo A-I is a native-like membrane mimetic system for G-protein-coupled receptors.

Apolipoprotein A-I (APOA1) Protein Überblick

Protein Überblick

This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.

Alternative names and synonyms associated with Apolipoprotein A-I (APOA1)

  • apolipoprotein A-I (APOA1)
  • apolipoprotein A-I-like (LOC100386212)
  • apolipoprotein A-I (apoa1)
  • apolipoprotein A-I (apoa-i)
  • apolipoprotein A-I (LOC100136573)
  • apolipoprotein A-I (Apoa1)
  • apolipoprotein A-I (APOAI)
  • apolipoprotein A-Ia (apoa1a)
  • Alp-1 Protein
  • Apo-AI Protein
  • apoa Protein
  • Apoa-1 Protein
  • apoA-I Protein
  • apoa1 Protein
  • ApoAI Protein
  • Brp-14 Protein
  • cb49 Protein
  • LOC100136573 Protein
  • Ltw-1 Protein
  • Lvtw-1 Protein
  • MGC64335 Protein
  • MGC89745 Protein
  • Sep-1 Protein
  • Sep-2 Protein
  • Sep2 Protein
  • wu:fb33f01 Protein
  • zgc:103718 Protein

Bezeichner auf Proteinebene für Apolipoprotein A-I Proteine (APOA1)

apolipoprotein A-I , apolipoprotein A-I-like , apolipoprotein A-I preproprotein , apo-AI , apoA-I , apolipoprotein A1 , apolipoprotein A-1 , preproapolipoprotein A-I , Apolipoprotein A1 , Apolipoprotein A-I , etID309895.5 , etID32161.5

GENE ID SPEZIES
425629 Gallus gallus
696969 Macaca mulatta
100386212 Callithrix jacchus
100528199 Ictalurus punctatus
379421 Xenopus laevis
448709 Xenopus (Silurana) tropicalis
778012 Takifugu rubripes
100126737 Papio anubis
100136573 Salmo salar
335 Homo sapiens
11806 Mus musculus
397691 Sus scrofa
100009253 Oryctolagus cuniculus
25081 Rattus norvegicus
396536 Gallus gallus
281631 Bos taurus
479427 Canis lupus familiaris
443373 Ovis aries
281632 Bos taurus
100454832 Pongo abelii
451564 Pan troglodytes
100196111 Salmo salar
101841336 Mesocricetus auratus
30355 Danio rerio
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