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Human Polyclonal ABCB4 Primary Antibody für IHC (p), WB - ABIN390060
Ruetz, Gros: Phosphatidylcholine translocase: a physiological role for the mdr2 gene. in Cell 1994
Show all 2 Pubmed References
ABCB4 variants identified in patients with biliary diseases
results are suggestive of a potential downstream molecular effect for the described polymorphisms on the expression pattern of the ABCB4 underlining the importance of synonymous variants
the first characterisation at the protein level of six ABCB4 variants (D243A, K435T, G535D, I490T, R545C, and S978P) previously found in patients with inflammatory liver diseases or liver cancer, is reported.
Ivacaftor is a potential therapy for selected patients with cystic fibrosis (zeige S100A8 Antikörper) with mutations of ABCB4.
Data show that patients with low multidrug resistance protein 3 (MDR3) expression were significantly associated with a better outcome than patients with high MDR3 expression.
In patients with intrahepatic cholestasis of pregnancy, ABCB4 gene mutation was not associated with response to ursodeoxycholic acid treatment.
Data suggest that MDR3 isoforms, both human and mouse isoforms, exhibit different affinities for fluorescent dyes and drugs; thus, ligands likely occupy partially overlapping but distinct binding sites.
Single-nucleotide polymorphism in ABCB4 gene is associated with gallbladder cancer.
the cholestatic potential of certain drugs may be aggravated by simultaneous inhibition of BSEP (zeige ABCB11 Antikörper) and MDR3.
Negative immunoreaction of MDR3 was found in the majority of the progressive familial intrahepatic cholestasis (PFIC (zeige ATP8B1 Antikörper)) group. Nonetheless, the negative immunoreaction was demonstrated in a considerable number of the non-PFIC (zeige ATP8B1 Antikörper) group. Negative MDR3 immunoreaction was more frequently associated with PFIC3 compared to non-PFIC (zeige ATP8B1 Antikörper) group.
In the rabbit cornea, the expression and activity of MDR1 transporter was confirmed, whereas human cell culture models and porcine corneas did not show MDR1 expression
These results provide evidence that zebrafish Pxr (zeige NR1I2 Antikörper) may play a role in MDR/MXR (zeige ABCG2 Antikörper) through transcriptional regulation of abcb4 and cyp3a65 gene expression.
Zebrafish Abcb4 plays crucial roles in cellular efflux of microcystin-LR and is a potential molecular marker for the monitoring of cyanobacteria contamination in the aquatic environment.
MDR1A deficiency restrains tumor growth in murine colitis-associated carcinogenesis.
multiple pathways, including MMP9 (zeige MMP9 Antikörper) cleavage and ubiquitinylation, mediated P-gp downmodulation.
using double electron-electron resonance and molecular dynamics simulations to describe the ATP- and substrate-coupled conformational cycle of the mouse ABC (zeige ABCB6 Antikörper) efflux transporter P-glycoprotein (Pgp; also known as ABCB1 (zeige ABCB1 Antikörper))
Mdr1a deficiency significantly enhanced the analgesic effect of aconitine and exacerbated its toxicity in the brain.
Chrysosplenetin inhibited P-gp activity and reverse the up-regulated P-gp and MDR1 levels induced by artemisinin.
Tamsulosin and tolterodine with P-gp gene expression and activity in an enantiomer-specific way.
These results indicate that nilotinib reverses P-gp- mediated MDR by blocking the efflux function and potentiates DOX-induced cardiotoxicity.
Results indicate that Abeta (zeige APP Antikörper) accumulates to a greater degree in brains of mice lacking MDR1A
[(18)F]Mefway is modulated by P-gp, and not by Bcrp (zeige ABCG2 Antikörper) in rodents.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined\; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.
ATP-binding cassette sub-family B member 4
, P glycoprotein 3/multiple drug resistance 3
, P-glycoprotein 3
, P-glycoprotein-3/multiple drug resistance-3
, multidrug resistance protein 3
, multiple drug resistance 3
, multi-drug resistance P-glycoprotein 1
, multidrug resistance protein 1
, ABC efflux transporter 4
, ATP-binding cassette, sub-family B (MDR/TAP), member 4
, ATP-binding cassette, subfamily B, member 4
, multidrug resistance 3
, ATP-binding cassette, sub-family B (MDR/TAP), member 1
, member 4
, sub-family B (MDR/TAP)
, ABC transporter protein
, ATP-binding cassette, subfamily B, member 1
, member 1
, subfamily B
, P glycoprotein 2
, multidrug resistance protein 2
, ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2
, ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2)
, ATP-binding cassette, sub-family B (MDR/TAP), member 4 (P-glycoprotein 3/ multidrug resistance 2)
, P-glycoprotein 2
, P-glycoprotein 3/ multidrug resistance 2
, multidrug resistance protein 3-like
, ATP-binding cassette transporter protein
, ATP-binding cassette sub-family B member 1A
, ATP-binding cassette, subfamily B, member 1A
, P glycoprotein 3
, ecotropic viral integration site 32
, multi-drug resistance 3
, multidrug resistance protein 1A
, multiple drug resistant 1a
, Beta-defensin 1
, Defensin, beta 1
, p-glycoprotein isoform III
, LOW QUALITY PROTEIN: phosphatidylcholine translocator ABCB4
, RUN domain containing 3B
, RUN domain-containing protein 3B
, phosphatidylcholine translocator ABCB4
, P glycoprotein 3/ multiple drug resistance 3