Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Select your species
These data indicate that PRN694 is a highly selective and potent covalent inhibitor of ITK (zeige ITK ELISA Kits) and RLK, and its extended target residence time enables durable attenuation of effector cells in vitro and in vivo.
fuctions as a Th1 (zeige TH1L ELISA Kits) cell-specific transcription factor and regulates IFN-gamma (zeige IFNG ELISA Kits) gene transcription
Th1 (zeige TH1L ELISA Kits) cells expressing Txk and Th1 (zeige TH1L ELISA Kits)-associated cytokines may play a critical role in the development of skin and intestinal lesions in patients with Behcet's disease.
Itk (zeige ITK ELISA Kits) and Txk exert their effects on T helper (Th) cell differentiation and function at the level of expression; transgenic Txk is not a specific regulator of Th1 (zeige TH1L ELISA Kits) responses.
Taken together, these data indicate that ITK (zeige ITK ELISA Kits) plus RLK inhibition may have therapeutic potential in Th1 (zeige HAND1 ELISA Kits)-mediated inflammatory diseases.
TXK plays an overlapping role with ITK (zeige ITK ELISA Kits) in iNKT cell development and function. ITK (zeige ITK ELISA Kits) also has a unique function in the survival of iNKT cells, likely via a p53 (zeige TP53 ELISA Kits)-dependent pathway.
The protein data combined with the association constants for binding of each proline-rich peptide to the corresponding SH3 domain (zeige ITSN1 ELISA Kits) provide an explanation for the opposing modes of self-association within the otherwise closely related Rlk and Itk (zeige ITK ELISA Kits) proteins
Tec kinases play key roles in regulating TCR-mediated polarization of integrins and signaling molecules to the site of TCR stimulation as well as the up-regulation of integrin adhesion.
A role for Rlk kinase is demonstrated in CD8 (zeige CD8A ELISA Kits)+ T cell signaling and function both in vitro and in vivo.
indicate a critical role for Itk (zeige ITK ELISA Kits) and Rlk in conventional CD8 (zeige CD8A ELISA Kits)(+) T cell development in the thymus
Tec (zeige NR4A3 ELISA Kits) kinases differentially regulate development of conventional versus nonconventional lymphocytes
Tec (zeige NR4A3 ELISA Kits) kinases Rlk and Itk (zeige ITK ELISA Kits) together provide important signals for terminal maturation, efficient cytokine production, and peripheral survival of natural killer T (NKT (zeige CTSL1 ELISA Kits)) cells.
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskekleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell- specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr- 201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
PTK4 protein tyrosine kinase 4
, protein-tyrosine kinase 4
, resting lymphocyte kinase
, tyrosine kinase
, tyrosine-protein kinase TXK
, TXK tyrosine kinase
, tyrosine-protein kinase TXK-like
, LOW QUALITY PROTEIN: tyrosine-protein kinase TXK