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Human TNFSF13 ELISA Kit für Sandwich ELISA - ABIN414805
Roderburg, Koch, Tacke, Nieuwenhuijsen, Bruensing, Vargas Cardenas, Kreggenwinkel, Vucur, Koppe, Jungebluth, Seikrit, Luedde, Trautwein, Luedde: Serum concentrations of A Proliferation-Inducing Ligand (APRIL) are elevated in sepsis and predict mortality in critically ill patients. in Journal of critical care 2013
BCMA (zeige TNFRSF17 ELISA Kits) has other contributors for ligands binding except DxL motif. The affinity of BCMA (zeige TNFRSF17 ELISA Kits) for APRIL higher than for BAFF (zeige TNFSF13B ELISA Kits) may be caused by the segment outside of the conservative DxL motif. Moreover, the exposition of new binding modes of BCMA2 interacting with APRIL may establish the foundation of designing novel drugs in the future
ApoE-/-APRIL-Tg mice have increased oxLDL-specific serum IgM levels, potentially mediated via an increase in B1a lymphocytes
Results showed that chemokine (zeige CCL1 ELISA Kits)-mediated recruitment of neutrophils secreting the tumor-promoting factor APRIL mediates DLBCL progression.
This study showed that both BAFF (zeige TNFSF13B ELISA Kits) and APRIL levels were increased in CSF (zeige CSF2 ELISA Kits) of patients with anti-NMDAR (zeige GRIN1 ELISA Kits) encephalitis.
New molecular mechanisms of in vivo Multiple Myeloma (MM) growth and immunosuppression critically dependent on BCMA (zeige TNFRSF17 ELISA Kits) and APRIL in the Bone marrow microenvironment, further supporting targeting this prominent pathway in MM.
Urinary APRIL (uAPRIL) and BAFF (zeige TNFSF13B ELISA Kits) (uBAFF) levels were raised significantly in AN.
Data did not detect any significant association with SNPs of APRIL, SPATA8, PDGFRA, and POLB with Systemic Lupus Erythematosus in Chinese Han Population.
Recombinant human APRIL (rhAPRIL) could rescue HCC (zeige FAM126A ELISA Kits) cell proliferation inhibited by miR (zeige MLXIP ELISA Kits)-383.
Host-derived proteins pp32 and APRIL interact with a free form of influenza virus RNA-dependent RNA polymerase and preferentially upregulates viral RNA synthesis rather than cRNA synthesis.
high expression of APRIL in clear cell renal cell carcinoma was correlated with high Fuhrman nuclear grade, high pathologic stage, and poor overall and cancer-specific survival of the patients
p40, a Lactobacillus rhamnosus-derived protein upregulates EGFR-dependent APRIL expression in intestinal epithelial cells, which may contribute to promoting IgA production
this study identifies APRIL as a new target involved in B-cell activation (zeige BLNK ELISA Kits), in the maintenance of plasma cell survival and subsequent increased autoantibody production that sustains lupus development in mice
this is the first study to implicate the APRIL signal transduction pathway in the pathogenesis of nephrogenic IgA production. Moreover, our findings identify APRIL as a potential target of therapy.
the elevated presence of APRIL and BLyS (zeige TNFSF13B ELISA Kits) in B cell-rich areas of chronically inflamed gingiva suggests that these cytokines may contribute to bone loss by promoting the survival and persistence of RANKL (zeige TNFSF11 ELISA Kits)-expressing B cells/plasma cells.
B cell activating factor (BAFF (zeige TNFSF13B ELISA Kits)) and a proliferation inducing ligand (APRIL) mediate CD40 (zeige CD40 ELISA Kits)-independent help by memory CD4 (zeige CD4 ELISA Kits) T cells in transplantations.
Heteromers consisting of one BAFF (zeige TNFSF13B ELISA Kits) and two APRIL bind to receptor TACI (zeige TNFRSF13B ELISA Kits), BCMA (zeige TNFRSF17 ELISA Kits) but not to BAFFR (zeige TNFRSF13C ELISA Kits).
Immunization of mice with a DNA vaccine encoding BAFF or APRIL multitrimers, together with interleukin 12 and membrane-bound HIV-1 Env gp140, induced neutralizing antibodies against tier 1 and tier 2 (vaccine strain) viruses.
APRIL selectively enhances axonal growth by activating ERK (zeige EPHB2 ELISA Kits) signaling and PI3-kinase (zeige PIK3CA ELISA Kits)/Akt (zeige AKT1 ELISA Kits)/GSK-3beta (zeige GSK3b ELISA Kits) signaling.
Data indicate that APRIL expression accelerates the onset of TCL1 (zeige TCL1A ELISA Kits)-driven leukemia formation mainly through TACI (zeige TNFRSF13B ELISA Kits) activation.
The ability of TACI (zeige TNFRSF13B ELISA Kits)-Fc to activate reverse signalling through BAFF (zeige TNFSF13B ELISA Kits) and APRIL, was investigated.
Although proliferation-inducing ligand TNFSF13/APRIL expression is dispensable for B cell development in the bone marrow, it is required for B cell development in gut (zeige GUSB ELISA Kits)-associated lymphoid tissue.
Cloning and expression analysis of a proliferation-inducing ligand (APRIL) provides the basis for investigation of its role in regulating rabbit B-lymphocyte (zeige AKAP17A ELISA Kits) development and immune responses.
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified\; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
TNF- and APOL-related leukocyte expressed ligand 2
, a proliferation-inducing ligand
, tumor necrosis factor ligand superfamily member 13
, tumor necrosis factor-like protein ZTNF2
, tumor necrosis factor-related death ligand-1
, SLAN protein
, Acidic leucine-rich nuclear phosphoprotein 32 family member B
, TNF superfamily member 13
, A proliferation-inducing ligand
, tumor necrosis factor ligand superfamily member 13 isoform alpha proprotein
, tumor necrosis factor (ligand) superfamily, member 13
, tumor necrosis factor superfamily member 13
, proliferation-inducing ligand
, tumor necrosis factor ligand 7B