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Human SH2D1A ELISA Kit für Sandwich ELISA - ABIN414747
Oberbach, Blüher, Wirth, Till, Kovacs, Kullnick, Schlichting, Tomm, Rolle-Kampczyk, Murugaiyan, Binder, Dietrich, von Bergen: Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes. in Journal of proteome research 2011
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High LAT1 expression correlated with significantly shorter prostate specific antigen recurrence-free survival in patients receiving androgen deprivation therapy
We describe here a novel c.137+5G > A intronic mutation in the SH2D1A gene of the signaling lymphocyte activation molecule (SLAM (zeige SLAMF1 ELISA Kits))-associated protein (SAP) in association with Epstein-Barr virus (EBV)-induced fatal infectious mononucleosis (FIM (zeige ZMYM2 ELISA Kits)) in an 8-year-old male patient and his 3-year-old step brother. The mother and the maternal grandmother of the boys are healthy and heterozygous for this sequence variant.
In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.
The mutation c.131G>A in this patient was found in combination with a second SH2D1A mutation
Study of SAP (zeige APCS ELISA Kits) expression is specific but may have insufficient sensitivity for screening XLP1 as a single tool; however, combination with 2B4 (zeige CD244 ELISA Kits) functional assay allows identification of all cases
Molecular dynamics analysis revealed that mutant R32Q and T53I structures of SAP (zeige APCS ELISA Kits) exhibited structural variation with respect to their backbone atoms before and after binding with the unphosphorylated SLAM (zeige SLAMF1 ELISA Kits) peptide.
Signaling lymphocytic activation molecule (SLAM)/SLAM (zeige SLAMF1 ELISA Kits)-associated protein pathway regulates human B-cell tolerance.
In patients suffering from X-linked lymphoproliferative disease (XLP1), SAP (zeige APCS ELISA Kits) is nonfunctional, not only abolishing the activating function of 2B4 (zeige CD244 ELISA Kits), but rendering this receptor inhibitory.
our data reveal how SAP (zeige APCS ELISA Kits) nucleates a previously unknown signaling complex involving NTB-A (zeige SLAMF6 ELISA Kits) and LCK (zeige LCK ELISA Kits) to potentiate restimulation-induced cell death of activated human T cells.
SAP (zeige APCS ELISA Kits) is a new actor downstream of PECAM-1 (zeige PECAM1 ELISA Kits) and its binding regulates PECAM-1 (zeige PECAM1 ELISA Kits) mediated cell adhesion.
SAP (zeige APCS ELISA Kits) is an essential molecule for autoimmune antibody production.
SLAM (zeige SLAMF1 ELISA Kits)-SAP (zeige APCS ELISA Kits) signaling promotes differentiation of IL-17 (zeige IL17A ELISA Kits)-producing T cells and progression of experimental autoimmune encephalomyelitis.
these data suggest that SAP (zeige APCS ELISA Kits) is critical for regulating type II NKT (zeige CTSL1 ELISA Kits) cell responses.
functional analysis in vitro indicates that SAP-2 is a non-functional isoform due to decreased protein stability
Here we report that B cell intrinsic responses to haptenated protein antigens are impaired in SAP (zeige APCS ELISA Kits)-/- mice and in Rag-/- mice into which B cells derived from SAP (zeige APCS ELISA Kits)-/- mice together with wt CD4 (zeige CD4 ELISA Kits)+ T cells had been transferred.
SAP (zeige APCS ELISA Kits) plays an essential role in CIA (zeige NCOA5 ELISA Kits) because of Fyn (zeige FYN ELISA Kits)-independent and Fyn (zeige FYN ELISA Kits)-dependent effects on TFH cells and, possibly, other T cell types.
SAP (zeige APCS ELISA Kits) was required not only for the initiation but also for the progression of primary T cell-driven B cell responses to haptens.
Loss of SAP (zeige APCS ELISA Kits) expression is associated with invariant NKT (zeige CTSL1 ELISA Kits) cell cytotoxicity and defective lytic synapse formation.
SAP (zeige APCS ELISA Kits) is required for the development of innate phenotype in H2-M3--restricted Cd8 (zeige CD8A ELISA Kits)(+) T cells.
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
serum amyloid P-component
, Duncan disease SH2-protein
, SH2 domain-containing protein 1A
, SLAM associated protein/SH2 domain protein 1A
, SLAM-associated protein
, T cell signal transduction molecule SAP
, T-cell signal transduction molecule SAP
, signaling lymphocyte activation molecule-associated protein
, signaling lymphocytic activation molecule-associated protein
, SH2 domain protein 1A
, Duncan disease homolog