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anti-Mouse (Murine) RABGEF1 Antikörper:
anti-Rat (Rattus) RABGEF1 Antikörper:
anti-Human RABGEF1 Antikörper:
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Chicken Monoclonal RABGEF1 Primary Antibody für IF, WB - ABIN968879
Horiuchi, Lippé, McBride, Rubino, Woodman, Stenmark, Rybin, Wilm, Ashman, Mann, Zerial: A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. in Cell 1997
Show all 3 Pubmed References
Chicken Monoclonal RABGEF1 Primary Antibody für IF, WB - ABIN968878
Rubino, Miaczynska, Lippé, Zerial: Selective membrane recruitment of EEA1 suggests a role in directional transport of clathrin-coated vesicles to early endosomes. in The Journal of biological chemistry 2000
Show all 3 Pubmed References
Human Polyclonal RABGEF1 Primary Antibody für ICC, IF - ABIN4348995
Lucitti, Sealock, Buckley, Zhang, Xiao, Dudley, Faber: Variants of Rab GTPase-Effector Binding Protein-2 Cause Variation in the Collateral Circulation and Severity of Stroke. in Stroke 2016
findings reveal a key role for RABGEF1 in dampening keratinocyte-intrinsic MYD88 (zeige MYD88 Antikörper) signaling and sustaining epidermal barrier function
Knockdown of RABEX-5 also inhibited wound healing, migration and the invasive abilities of gastric cancer cells.
Hyperinsulinemia induced insulin (zeige INS Antikörper) resistance in 3T3-L1 adipocytes by retaining GLUT4 (zeige SLC2A4 Antikörper) in a Rab5 (zeige RAB5A Antikörper)-activity-dependent compartment.
Kruppel-like factor 5 (zeige KLF5 Antikörper) is indispensable for adhesion, homing, lodging and retention of haematopoietic stem cells and progenitors in the bone marrow through Rab5 (zeige RAB5A Antikörper)-dependent post-translational regulation of beta1/beta2 integrins
Rab5 (zeige RAB5A Antikörper) is required for phagocytosis of heat-inactivated Pseudomonas aeruginosa by macrophages.
Rabex-5 regulates neurite morphogenesis of hippocampal neurons by activating at least two downstream targets, Rab5 (zeige RAB5A Antikörper), which is localized in both axons and dendrites, and Rab17 (zeige RAB17 Antikörper), which is localized in dendrites alone
a novel mechanistic insight into how Rabex-5 regulates internalization and postendocytic trafficking of ubiquitinated L1 destined for lysosomal degradation.
Data show that RabGEF1 can negatively regulate thymic stromal lymphopoietin (TSLP (zeige TSLP Antikörper)) production in vivo and that excessive production of TSLP (zeige TSLP Antikörper) contributes to many of the phenotypic abnormalities in Rabgef1-/- mice.
Data reveal the affinity of Rabex-5/Rabaptin-5 (zeige RABEP1 Antikörper)/Rab5 (zeige RAB5A Antikörper)-GTP (zeige AK3 Antikörper) interaction in the cell, which is quantitatively related to the Rabex-5 concentration for the onset of the indirect positive feedback pathway.
Data report the identification of Rab22 (zeige RAD51AP1 Antikörper) as a binding site on early endosomes for direct recruitment of Rabex-5 and activation of Rab5 (zeige RAB5A Antikörper), establishing a Rab22 (zeige RAD51AP1 Antikörper)-Rab5 (zeige RAB5A Antikörper) signaling relay to promote early endosome fusion.
RABGEF1 mediates recycling endosome fusion with GAS-containing autophagosome-like vacuoles through the STX6-VAMP3-VTI1B complex; SNAREs are involved in autophagosome formation in response to bacterial infection
The results contradict the model of feedback activation of Rab5 (zeige RAB5A Antikörper) and instead indicate that Rbpt5 is recruited by both Rabex5 recognizing ubiquitylated cargo and by Rab4 (zeige RAB4A Antikörper) to activate Rab5 (zeige RAB5A Antikörper) in a feed-forward manner.
RABEX-5 is a potential useful indicator and predicts a poor long-term prognosis for small cell lung cancer(SCLC), which should be considered in defining the prognosis with other well-known prognosticators in C-SCLC patients
Expression of RABEX-5 is significantly higher in gastric cancer tissues and is associated with tumor size and lymph node metastasis.
analysis of Rabex-5 GEF (zeige SLC2A4RG Antikörper) activation by Rabaptin-5 (zeige RABEP1 Antikörper)
This implies that Rap (zeige LRPAP1 Antikörper) regulates endothelial barrier function by dual control of cytoskeletal tension. The molecular details of the signaling pathways are becoming to be elucidated
RABEX-5 mRNA expression is a strong predictor of poor prognosis in prostate cancer patients treated by radical prostatectomy.
Interaction of Rabex-5 with Rab5 (zeige RAB5A Antikörper) depends on interaction of the MIU domain with the ubiquitinated L1 to drive its internalization.
KCa2.3 (zeige KCNN3 Antikörper) is localized to a caveolin-rich domain within the plasma membrane and is endocytosed in a dynamin (zeige DNM1 Antikörper)- and Rab5 (zeige RAB5A Antikörper)-dependent manner.
these data suggest differential physiological roles of the two ubiquitin binding domains in Rabex-5.
Receptor recycling is mediated by AP-1 (zeige JUN Antikörper)/clathrin-coated vesicles and regulated by rab4 (zeige RAB4A Antikörper) and rabaptin-5 (zeige RABEP1 Antikörper)/rabex-5.
Rabex-5 is a ubiquitin ligase that binds ubiquitin and undergoes ubiquitination; the N-terminal region of Rabex-5 (residues 1-76) is important for ubiquitin binding and ubiquitination.
The structure of the N-terminal portion of Rabex-5 bound to ubiquitin at 2.5-A resolution shows that Rabex-5-ubiquitin interactions occur at two sites
Rabex-5 can target to early endosomes via the EET domain and activate Rab5 (zeige RAB5A Antikörper) in a Rabaptin-5 (zeige RABEP1 Antikörper)-independent manner in vivo.
Data show that ubiquitin binding is essential for the recruitment of Rabex-5 from the cytosol to endosomes, independently of its guanine nucleotide exchange factor (zeige ARHGEF12 Antikörper) activity and of Rab5 (zeige RAB5A Antikörper).
RABGEF1 forms a complex with rabaptin-5 (RABPT5\; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A\; MIM 179512) (Horiuchi et al., 1997
Rab5 exchange factor
, Ras negative regulator Rabex-5
, Ras negative regulator Rabex-5/Rin2
, rab5 GDP/GTP exchange factor
, rabaptin-5-associated exchange factor for Rab5
, Rab5 guanine nucleotide exchange factor Rabex-5
, RAB guanine nucleotide exchange factor (GEF) 1
, Rab5 GDP/GTP exchange factor
, BTB/POZ domain-containing protein KCTD7
, RAB guanine nucleotide exchange factor (GEF) 1 L homeolog