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These results identify IL-27 (zeige IL27 ELISA Kits) and its specific receptor IL27RA as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection.
Findings demonstrated that IL-27 (zeige IL27 ELISA Kits) and IL-27R were elevated in multiple sclerosis lesions and that local IL-27 (zeige IL27 ELISA Kits) can modulate immune properties of astrocytes and infiltrating immune cells
The significant expression of IL-27 (zeige IL27 ELISA Kits) in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor (zeige EBI3 ELISA Kits) pair is detrimental in TB.
natural sIL (zeige PMEL ELISA Kits)-27Ralpha binds rIL (zeige PDLIM4 ELISA Kits)-27, inhibits IL-27 (zeige IL27 ELISA Kits) binding to its cell surface receptor, and is a potent inhibitor of IL-27 (zeige IL27 ELISA Kits) signaling, as shown by its ability to specifically block IL-27 (zeige IL27 ELISA Kits)-mediated STAT (zeige STAT1 ELISA Kits) activation, at low molar excess over IL-27 (zeige IL27 ELISA Kits).
Aberrant hypermethylation and reduced expression of IL27RA is associated with myelodysplastic syndromes.
TCCR/WSX-1 is closely associated with angiogenesis and could serve as a novel therapeutic target in patients with age-related macular degeneration.
Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity.
WSX-1 is essential for transcriptional activation of STAT1 (zeige STAT1 ELISA Kits) and for augmenting the induction of T-bet expression during initiation of Th1 (zeige TH1L ELISA Kits) cell differentiation.
WSX-1 together with the cytokine receptor (zeige EBI3 ELISA Kits) gp130 (zeige IL6ST ELISA Kits) constitutes a functional signal-transducing receptor for IL-27 (zeige IL27 ELISA Kits).
IL-27R possesses hematopoietic cell-transforming properties
The combination of mutant p53 (zeige TP53 ELISA Kits) & IL27RA(-/-) causes spontaneous liver inflammation, steatosis, and fibrosis, whereas either gene alone has no effects on the liver.
IL-10 (zeige IL10 ELISA Kits) production by CD4 (zeige CD4 ELISA Kits)(+) YFP(+) T cells is controlled systemically during malaria infection through IL-27 (zeige IL27 ELISA Kits) receptor signaling that is supported after CD4 (zeige CD4 ELISA Kits)(+) T cell priming by ICOS (zeige ICOS ELISA Kits) signaling.
The significant expression of IL-27 (zeige IL27 ELISA Kits) in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor (zeige LEPR ELISA Kits) pair is detrimental in TB.
IL-27R-mediated regulation of IL-17 (zeige IL17A ELISA Kits) controls the development of respiratory syncytial virus-associated pathogenesis.
CCL4 and CCL5 expression was higher in livers of infected WSX-1(-/-) mice than infected WT mice, and hepatic CD4 T cells from WSX-1(-/-) mice expressed higher levels of CCR5 than cells from WT mice
The loss of IL-27R signaling across the whole mouse resulted in reduced viral control and a slight increase in the number of virus-specific CD4 (zeige CD4 ELISA Kits) T cells at early stages of viral infection.
Diminution of the Th1 response in infected Il27ra mice in vivo by neutralization of IL-12p40 attenuated CCR5 expression.
These findings establish a novel antiatherogenic role for IL-27 (zeige IL27 ELISA Kits) receptor signaling, which acts to suppress the production of proinflammatory cytokines and chemokines and to curb the recruitment of inflammatory myeloid cells into atherosclerotic aortas.
In Th1 (zeige HAND1 ELISA Kits)-dependent autoinflammatory lesions, IL-27Ralpha has a biphasic role in vivo, initially pathogenic, but ultimately playing a protective role by regulating immune responses and attenuating disease.
Data show that the deletion of Il27ra ameliorates pathology in the pristane-induced SLE model.
In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.
interleukin 27 receptor, alpha
, class I cytokine receptor
, interleukin-27 receptor subunit alpha
, type-I T cell cytokine receptor
, IL-27 receptor subunit alpha
, IL-27R subunit alpha
, T-cell cytokine receptor type 1
, cytokine receptor WSX-1
, cytokine receptor-like 1
, type I T-cell cytokine receptor
, T cell cytokine receptor
, T cell cytokine receptor; cytokine receptor family, class 1 (WSXWS), member 1
, cytokine receptor family, class 1 (WSXWS), member 1