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Human IL23A Protein expressed in Wheat germ - ABIN1307786
Wang, Zhong, Zheng, Li, Chen, Ma, Sun, Yan, Li: Damage effect of interleukin (IL)-23 on oxygen-glucose-deprived cells of the neurovascular unit via IL-23 receptor. in Neuroscience 2015
IL-23 activates gammadelta T cells in early stage PNS, which amplifies the Th17 cell population and leads to kidney injury through the secretion of IL-21 (zeige IL17C Proteine).
serum IL-23 levels reflect obstructive sleep apnea syndrome -related systemic inflammation and are a useful marker for improvement following continuous positive airway pressure therapy
This study is the first to demonstrate an effect of HIV on the IL-23 signaling pathway in Th17 cells. We show that in vitro and in vivo HIV infection results in impaired IL-23 signaling which is not reversed by HAART nor is it a result of reduced receptor expression, suggesting that HIV interferes with IL-23-activated signaling pathways
We conclude that variants in IL-23A and IL-23R (zeige IL23R Proteine) genes were associated with the risk of multiple sclerosis or other inflammatory demyelinating diseases.
results confirm the role of IFN-gamma (zeige IFNG Proteine) and support the involvement of IL-23/Th17-related cytokines in BCC pathogenesis and in the inflammatory response during IMQ and MAL-PDT (zeige TWIST1 Proteine) treatments
An increase in CSF (zeige CSF2 Proteine) mean levels of IL-23 was observed in amyotrophic lateral sclerosis patients.
results show that IL-23 accounts for the main aspects of human and murine lupus including the expansion of double negative T cells, decreased IL-2 (zeige IL2 Proteine), and increased IL-17 (zeige IL17A Proteine) production
Serum Levels of IL-17A (zeige IL17A Proteine) and IL-23 Are Associated with Decreased Vitamin D3 and Increased Pain in Osteoarthritis
this study shows that latent cytomegalovirus induces IL-23. IL-23 might be an inflammatory mediator of latent cytomegalovirus infection in patients with rnd-stage renal diseases, and predisposes patients for post-transplant cytomegalovirus reactivation
These finding may provide a molecular mechanism involved in sustained ER stress in AS BdCs stimulates the activation of RUNX2 (zeige RUNX2 Proteine) and C/EBPbeta (zeige CEBPB Proteine) genes, leading to IL-23 production.
this study unveiled the role of IL-23-dependent IL-17 (zeige IL17A Proteine) induction in LdCen-/- parasite-induced immunity and subsequent protection against visceral leishmaniasis
Results reveal the importance of the IL-23/IL-17 (zeige IL17A Proteine) inflammatory axis in secondary brain injury after intracerebral hemorrhage.
RIG-I (zeige DDX58 Proteine) expression is markedly increased in the affected skin derived from psoriasis patients and from both IL-23- and imiquimod -induced psoriasis-like mouse model.
this study shows that IL-23 but not IL-1 (zeige IL1A Proteine) contributes to the IL-17A (zeige IL17A Proteine) expression induced by subacute O3 exposure
IL-23 released by keratinocytes in response to endogenous TLR4 (zeige TLR4 Proteine) ligands causes skin DCs, which selectively express IL-23R (zeige IL23R Proteine), to up-regulate their endogenous IL-23 production and drive an IL-22 (zeige IL22 Proteine) response in naive CD4 (zeige CD4 Proteine)(+) T cells that mediates epidermal thickening.
In mice overexpressing IL23, enthesis-resident gamma/delta T cells accumulate in the enthesis, ciliary body, and aortic valve.
we describe here a new IL-12 member IL-39 (IL-23p19/Ebi3) secreted by activated B cells that mediate inflammatory responses in lupus-like mice. Thus, IL-39 might contribute to immunopathogenic mechanisms of SLE.
These data identify the important contributions of IL-23 to the development of elastase-induced pulmonary inflammation and emphysema.
The inflammatory phenotype in barrier-defective skin is shaped by counterregulation between the TSLP (zeige TSLP Proteine)/type 2 and IL-23/type 17 axes.
These results provide genetic information about both swine IL-23 the IL-23 receptor alpha (IL-23Ralpha) and IL-12 receptor beta1 (IL-12Rbeta1), which allows for better understanding of interleukin systems involved in pig immunity.
cloning and characterization of interleukin-17 (zeige IL17A Proteine) expressed gene sequence from mRNA obtained from intestinal tissue and interleukin-23 expressed gene sequence from mRNA obtained from peripheral blood mononuclear cells
This study examined effects of in vitro exposure to solutions of hay (zeige GTF2H5 Proteine) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.
This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells.
IL-23 subunit alpha
, JKA3 induced upon T-cell activation
, interleukin 23 p19 subunit
, interleukin-23 subunit alpha
, interleukin-23 subunit p19
, interleukin-six, G-CSF related factor
, IL-23 p19 subunit
, Interleukin-23 p19 subunit
, interleukin 23 p19