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Our findings provide evidence that during renal allograft rejection HLA-E along with high numbers of mismatched HLA-class I (zeige MICA ELISA Kits) leader peptides might represent additional targets for immune-activating responses.
The results suggest that HLA-E allelic variants may play a role in the modulation of immune responses in the context of the inability of natural conception and establishment of a viable pregnancy.
The prognostic benefit of natural killer cells, but not T-cells, is influenced by HLA-E expression in endometrial cancer.
This data reinforces the presence of only two main full-length HLA-E molecules encoded by the many HLA-E alleles detected in our population sample. In addition, this data does indicate that the distal HLA-E promoter is by far the most variable segment.
HLA-E alleles and sHLA-E levels may represent novel biomarkers for early disease progression in patients with chronic lymphocytic leukemia
In insulitic islets from living patients with recent-onset T1D, most of the overexpressed ISGs, including GBP1 (zeige GBP1 ELISA Kits), TLR3 (zeige TLR3 ELISA Kits), OAS1 (zeige OAS1 ELISA Kits), EIF2AK2 (zeige EIF2AK2 ELISA Kits), HLA-E, IFI6 (zeige IFI6 ELISA Kits), and STAT1 (zeige STAT1 ELISA Kits), showed higher expression in the islet core compared with the peri (zeige PLIN1 ELISA Kits)-islet area containing the surrounding immune cells
soluble HLA-Ib molecules HLA-G and HLA-E are present in BM plasma samples in physiological and pathological conditions, and their concentration correlated with stage disease in NB patients.
this study shows the high expression of HLA-E in actinic chelitis and in lip squamous cell carcinoma, which reflects the capacity that these pathologies have for evasion and progression
Our study reveals that HLA-E polymorphism is associated with nasopharyngeal cancer.
High expression of HLA-E is associated with non-small cell lung carcinoma.
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.
HLA class I histocompatibility antigen, E alpha chain
, HLA class I histocompatibility antigen, alpha chain E
, MHC HLA-E alpha-1
, MHC HLA-E alpha-2.1
, MHC class I antigen E
, lymphocyte antigen