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These data implicate the prevalent African allele HLA-B*53:01 in the immunopathogenesis of raltegravir-induced DRESS syndrome.
results demonstrate that HIV-1 Nef's inferior ability to downregulate MHC-B compared to that of MHC-A is conserved across primate lentiviruses and suggest that this property influences antiviral cellular immune responses.
Three new HLA class I alleles, HLA-A*02:620, HLA-B*27:150 and HLA-B*07:05:01:02, were described in the Spanish Caucasoid population
Genetically, the strong primary sclerosing cholangitis (PSC) risk factors HLA-B*08 and DRB1 (zeige RBM45 ELISA Kits)*03 were more prevalent in Antineutrophil cytoplasmic antibodies (ANCA) -positive than -negative patients. In UC patients without liver disease, HLA-DRB1 (zeige HLA-DRB1 ELISA Kits)*03 was more prevalent in pANCA-positive compared with -negative patients.Antineutrophil cytoplasmic antibodies identified PSC patients with clinical and genetic characteristics.
The goal of this study was to evaluate the impact of EHR point-of-care tools on medical record documentation of genetic testing care processes for the common HFE mutations, a thrombophilia panel, and HLA-B27.
This review focuses on the ambivalent role of HLA-B27 in autoimmunity and viral protection correlating its functions to the quantitative and qualitative effects of ERAP1 (zeige ERAP1 ELISA Kits) and ERAP2 (zeige ERAP2 ELISA Kits) polymorphisms on their enzymatic activity.
The association between HLA-B*57 and pemphigus vulgaris (zeige DSG3 ELISA Kits) is reported for the first time in the present study.
Arginine (di)methylated human leukocyte antigen class I peptides, which are asymmetrically dimethylated, most likely by CARM1, are favorably presented by HLA-B*07.
This study demonstrated that the expression of a single human class I MHC molecule, independent of persistent virus infection, influences the extent of sub frequent chronic neuronal injury or repair in the absence of a class II MHC immune response.
The HLA-B*50 allele was associated with conversion to myasthenia gravis generalized disease in patients with pure ocular symptoms at disease onset.
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
major histocompatibility complex, class I, B
, HLA class I histocompatibility antigen, B alpha chain
, MHC Class I HLA heavy chain
, MHC HLA-B cell surface glycoprotein
, MHC HLA-B transmembrane glycoprotein
, MHC class I antigen GN00104
, MHC class I antigen HLA-B heavy chain
, MHC class I antigen SHCHA
, leukocyte antigen class I-B
, lymphocyte antigen