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Single-nucleotide polymorphisms FOXF1 rs9936833 and MHC rs9257809 remained significantly associated with presence of gastroesophageal acid reflux. The association for risk allele C in FOXF1 rs9936833 and risk allele A in MHC rs9257809 with the presence of acid reflux suggests a potential pathophysiologic mechanism for the role of genetic influences in Barret Esophagus development.
FOXF1 mutations may have an extremely variable phenotype, possibly as a result of somatic mosaicism and complex gene regulation.
There were decreased levels of Gsa (zeige GNAS ELISA Kits), FOXF1, CREB1 (zeige CREB1 ELISA Kits), and phosphorylated CREB1 (zeige CREB1 ELISA Kits) proteins in intestinal muscle layers of patients with chronic intestinal pseudo-obstruction, compared with tissues from controls.
Data show that MeCP2 promotes gastric cancer (GC) cell proliferation via FOXF1-mediated Wnt5a (zeige WNT5A ELISA Kits)/beta-Catenin (zeige CTNNB1 ELISA Kits) signaling pathway, and suppresses GC cell apoptosis through MYOD1 (zeige MYOD1 ELISA Kits)-mediated Caspase-3 (zeige CASP3 ELISA Kits) signaling pathway.
Results show that FoxF1 increases invasiveness of breast cancer cells by upregulating LOX (zeige LOX ELISA Kits).
we provide supportive evidence that genetic variants at FOXP1 (zeige FOXP1 ELISA Kits), BARX1 (zeige BARX1 ELISA Kits), and FOXF1 confer risk for the development of EAC (zeige CYLD ELISA Kits).
Point mutations of FOXF1 gene is associated with alveolar capillary dysplasia.
Targeted Resequencing of 29 Candidate Genes and Mouse Expression Studies Implicate ZIC3 (zeige ZIC3 ELISA Kits) and FOXF1 in Human VATER/VACTERL Association
FOXF1 inhibits hematopoietic lineage commitment during early mesoderm specification.
FOXF1 behaved not only as a reprogramming regulator that mediates stemness but also as a putative tumor suppressor that contributes to p21 (zeige CDKN1A ELISA Kits)-regulated growth suppression during fusion process
Results provide support for the function of FoxF1 in the development of visceral mesoderm and the organogenesis of the gut (zeige GUSB ELISA Kits).
Expression of Bmp4 (zeige BMP4 ELISA Kits) in the ureteric mesenchyme depends on HH signaling and Foxf1, and that exogenous BMP4 (zeige BMP4 ELISA Kits) rescued cell proliferation and epithelial differentiation in ureters with abrogated HH signaling or FOXF1 function.
The Gli (zeige GLI1 ELISA Kits) increased the activity of one of these long-range enhancers, which was specific to distal blood vessel, suggesting that Shh (zeige SHH ELISA Kits) regulates Foxf1 transcription in pulmonary distal blood vessel formation.
Data indicate that forkhead box F1 (Foxf1) deletion from endothelial cells decreases the abundance of sphingosine 1-phosphate receptor 1 (S1PR1 (zeige S1PR1 ELISA Kits)).
novel Shh (zeige SHH ELISA Kits)-Foxf-Fgf18 (zeige FGF18 ELISA Kits)-Shh (zeige SHH ELISA Kits) circuit in the palate development molecular network, in which Foxf1 and Foxf2 (zeige FOXF2 ELISA Kits) regulate palatal shelf growth downstream of Shh (zeige SHH ELISA Kits) signaling, at least in part, by repressing Fgf18 (zeige FGF18 ELISA Kits) expression
findings suggest that Foxf1 may serve as a target gene to disrupt progression of liver fibrosis and DBTC might provide a potentially feasible and effective tool for HSC (zeige FUT1 ELISA Kits)-specific delivery of therapeutic RNA
Our findings implicate Foxf genes(Foxf1a and Foxf2 (zeige FOXF2 ELISA Kits) ) in atrioventricular septation, describe the molecular underpinnings of the genetic interaction between Hedgehog (zeige SHH ELISA Kits) signaling and Tbx5 (zeige TBX5 ELISA Kits)
Data indicate FOXF1 transcription factor is required for the formation of embryonic vasculature by regulating endothelial genes critical for vascular development and vascular endothelial growth factor signaling.
Endodermal Shh (zeige SHH ELISA Kits) and mesenchymal Foxf1 genes expression were preserved around the hindgut cystic malformation.
Foxf1 also directly binds to serum response factor (SRF) and myocardin-related transcription factors (MRTFs).
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined\; however, it may play a role in the regulation of pulmonary genes as well as embryonic development.
forkhead box F1
, forkhead box protein F1
, forkhead box F protein
, Forkhead, drosophila, homolog-like 5
, forkhead-related activator 1
, forkhead-related protein FKHL5
, forkhead-related transcription factor 1
, fork head domain-related protein 13
, forkhead box protein F1-A
, forkhead transcription factor
, HNF-3/forkhead homolog 8
, forkhead box F1a
, hepatocyte nuclear factor 3 forkhead homolog 8
, HNF-3/fork-head homolog-5 (HFH-5)
, forkhead box protein I2
, hepatocyte nuclear factor 3 forkhead homolog 5