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Human FCGRT Protein expressed in Wheat germ - ABIN1353903
Deissler, Lang, Lang: Internalization of bevacizumab by retinal endothelial cells and its intracellular fate: Evidence for an involvement of the neonatal Fc receptor. in Experimental eye research 2015
Human FCGRT Protein expressed in HEK-293 Cells - ABIN2720989
Fan, Neubert: Quantitative Analysis of Human Neonatal Fc Receptor (FcRn) Tissue Expression in Transgenic Mice by Online Peptide Immuno-Affinity LC-HRMS. in Analytical chemistry 2016
An arginine-to-histidine replacement at residue 435 in the binding domain of IgG3 to FcRn increases the transplacental transfer and half-life of malaria-specific IgG3 in young infants and is associated with reduced risk of clinical malaria during infancy.
these findings establish a novel mechanism of humoral protection in the eye involving FcRn and may facilitate vaccine and therapeutic development for other ocular surface diseases
Data suggest that, unlike albumin (zeige ALB Proteine) with low FcRn-binding affinity, albumin (zeige ALB Proteine) with high FcRn-binding affinity (due to genetic variation/genetic engineering) is directed less to lysosomes and more to endosomes, suggestive of FcRn-directed albumin (zeige ALB Proteine) salvage from lysosomal degradation. (FcRn = neonatal Fc receptor)
the localization of FcRn alpha-chain in fixed nasal tissue, was studied.
FcRn is involved in transport of aflibercept through REC in vitro.
this study shows that FcRn may be associated with the transport and metabolism of IgG in thyrocytes and that transport is independent of IgG type, and that FcRn may be involved in Hashimoto's thyroiditis pathogenesis
This review summarizes the main findings on Fc Receptor neonatal biology, function and distribution throughout different tissues.
The results suggest that regardless of hyperglycemia degree, it decreases FcRn expression in placenta and blood cells and compromises the production and transfer of antibodies from maternal blood to newborns.
Data indicate improved pharmacokinetics through enhanced neonatal Fc receptor (FcRn) interactions were apparent for a complementarity-determining region (CDR (zeige RUNX1T1 Proteine)) charge-patch normalized monoclonal antibody (mAb) which was affected by non-specific clearance.
analysis of binding motifs in the hFCGRT promoter that interact with their corresponding (Sp1 (zeige PSG1 Proteine), Sp2, Sp3, c-Fos, c-Jun (zeige JUN Proteine), YY1 (zeige YY1 Proteine), and C/EBPbeta (zeige CEBPB Proteine) or C/EBPdelta (zeige CEBPD Proteine)) transcription factors (TFs) suggests their involvement in regulation of human FCGRT gene expression
The transport of IgGs in the mammary gland, by FcRn, was investigated.
The present data support the notion that FcRn might be involved in the transfer of maternal immunoglobulins and in the local defense mechanism of the mammary gland.
FcRn alpha chain gene has acquired several repetitive sequences in its 5'-flanking region, including multiple SINE and LINE elements. Potential binding sites for transcription factors within the 5'-flanking sequence were identified
haplotype could also weaken the IgG-FcRn affinity, which may increase the IgG concentration in the milk.
Preproinsulin (zeige INS Proteine) fused to Fc administered to pregnant mice efficiently accumulated in fetuses through the placental neonatal Fc receptor and protected them from subsequent diabetes development.
The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.
Characterization and screening of IgG binding to the neonatal Fc receptor.
Fc receptor promotes formation of subepithelial immune complexes and subsequent glomerular pathology leading to proteinuria
Abundant intracellular IgG in enterocytes and endoderm lacking FcRn.
Extending serum half-life of albumin (zeige ALB Proteine) by engineering neonatal Fc receptor (FcRn) binding.
FcRn thus has a primary role within mucosal tissues in activating local immune responses that are critical for priming efficient anti-tumor immunosurveillance
Neonatal Fc receptor for IgG uptake mediates intestinal absorption of IgG(1) anti-IgE/IgE immune complexes.
Nck (zeige NCK1 PLURAL_@40084@) and Cdc42 (zeige CDC42 PLURAL_@40084@) co-operate to recruit N-WASP (zeige WASL PLURAL_@40084@) to promote FcgammaR-mediated phagocytosis.
AMG (zeige AMELX Proteine) 386 clearance in FcRn-knockout mice was 18-fold faster at the 3-mg/kg dose.
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants.
FcRn alpha chain
, IgG Fc fragment receptor transporter alpha chain
, IgG receptor FcRn large subunit p51
, immunoglobulin receptor, intestinal, heavy chain
, major histocompatibility complex class I-like Fc receptor
, neonatal Fc receptor
, neonatal Fc-receptor for Ig
, IgG transcytosis and recycling receptor
, MHC class I-related Fc gamma receptor
, igG receptor FcRn large subunit p51
, neonatal Fc receptor FcRn
, Fc receptor
, Fc fragment immunoglobulin G receptor
, Fc receptor, IgG, alpha chain transporter
, igG Fc fragment receptor transporter alpha chain